Role of neuroimaging in first seizure diagnosis
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TLDR
The role of neuroimaging in the assessment of a first seizure, the current state of the art and possible future directions are described.Abstract:
The primary goal of neuroimaging in a first, unprovoked seizure is to identify a lesion that can explain the seizure. Secondarily, neuroimaging may be used to predict seizure recurrence and assist with the diagnosis of epilepsy. However, the events leading from a first seizure to epilepsy, with or without an identifiable epileptogenic lesion, are not well understood, and it is not always clear which lesions are epileptogenic as opposed to incidental. Much neuroimaging research to date has focused on findings in chronic epilepsy, rather than first seizure. Dedicated epilepsy imaging with high quality MRI protocols maximizes the likelihood of a diagnosis. However, a significant proportion of patients are MRI-negative, prompting researchers in the field to continue the search for better imaging strategies. Here we describe the role of neuroimaging in the assessment of a first seizure, the current state of the art and possible future directions.read more
Citations
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Journal ArticleDOI
The ENIGMA-Epilepsy working group: Mapping disease from large data sets.
Sanjay M. Sisodiya,Christopher D. Whelan,Sean N. Hatton,Khoa H Huynh,Andre Altmann,Mina Ryten,Annamaria Vezzani,Maria Eugenia Caligiuri,Angelo Labate,Antonio Gambardella,Victoria L. Ives-Deliperi,Stefano Meletti,Brent C. Munsell,Leonardo Bonilha,Manuela Tondelli,Michael Rebsamen,Christian Rummel,Anna Elisabetta Vaudano,Roland Wiest,Akshara R. Balachandra,Akshara R. Balachandra,Núria Bargalló,Emanuele Bartolini,Andrea Bernasconi,Neda Bernasconi,Boris C. Bernhardt,Benoit Caldairou,Sarah J. A. Carr,Gianpiero L. Cavalleri,Fernando Cendes,Luis Concha,Patricia Desmond,Martin Domin,John S. Duncan,Niels K. Focke,Renzo Guerrini,Khalid Hamandi,Khalid Hamandi,Graeme D. Jackson,Neda Jahanshad,Reetta Kälviäinen,Simon S. Keller,Simon S. Keller,Peter Kochunov,Magdalena A. Kowalczyk,Barbara A. K. Kreilkamp,Barbara A. K. Kreilkamp,Patrick Kwan,Sara Larivière,Matteo Lenge,Seymour M. Lopez,Pascal Martin,Mario Mascalchi,José C. V. Moreira,Marcia Morita-Sherman,Marcia Morita-Sherman,Heath R. Pardoe,Jose C. Pariente,Kotikalapudi Raviteja,Cristiane S. Rocha,Raúl Rodríguez-Cruces,Raúl Rodríguez-Cruces,Margitta Seeck,Mira K.H.G. Semmelroch,Mira K.H.G. Semmelroch,Benjamin Sinclair,Hamid Soltanian-Zadeh,Hamid Soltanian-Zadeh,Dan J. Stein,Pasquale Striano,Peter N Taylor,Rhys H. Thomas,Sophia I. Thomopoulos,Dennis Velakoulis,Lucy Vivash,Lucy Vivash,Bernd Weber,Clarissa L. Yasuda,Junsong Zhang,Paul M. Thompson,Carrie R. McDonald +80 more
TL;DR: The ENIGMA-Epilepsy Consortium as mentioned in this paper was established to strengthen epilepsy neuroscience by greatly increasing sample sizes, leveraging ideas and methods established in other EnigMA projects, and generating a body of collaborating scientists and clinicians to drive forward robust research.
Journal ArticleDOI
Long-term applicability of the new ILAE definition of epilepsy. Results from the PRO-LONG study
Simone Beretta,Davide Carone,Clara Zanchi,Elisa Bianchi,Marta Pirovano,Claudia Trentini,Giada Padovano,Matteo Colombo,D Cereda,Sofia Scanziani,Giorgia Giussani,Sara Gasparini,Graziella Bogliun,Carlo Ferrarese,Ettore Beghi +14 more
TL;DR: Long‐term follow-up of patients diagnosed after a single seizure is needed to assess the applicability of the new epilepsy definition in clinical practice.
Journal ArticleDOI
Imaging Evaluation of the Adult Presenting With New-Onset Seizure
TL;DR: Evidence supporting the use of neuroimaging in adult patients presenting with new-onset seizure is discussed and MRI has added benefits and should be considered for adults presenting acutely for whom the initial CT is negative.
Journal ArticleDOI
Predictive value of functional MRI and EEG in epilepsy diagnosis after a first seizure
Gerhard S. Drenthen,Gerhard S. Drenthen,Jacobus F.A. Jansen,Erik D. Gommer,Lalit Gupta,Paul A. M. Hofman,Vivianne van Kranen-Mastenbroek,Danny M. W. Hilkman,Marielle C.G. Vlooswijk,Rob P.W. Rouhl,Walter H. Backes +10 more
TL;DR: Temporal metrics computationally derived from EEG and fMRI time signals may clinically aid and synergistically improve the predictive value in a first-seizure sample and show significant improvements compared to the clinical diagnosis.
Journal ArticleDOI
Expedited epilepsy surgery prior to drug resistance in children: a frontier worth crossing?
Andrew T. Hale,Aswin Chari,Rod C. Scott,J. Helen Cross,Curtis J. Rozzelle,Jeffrey P. Blount,Martin Tisdall +6 more
TL;DR: The clinical and experimental evidence for selectively considering epilepsy surgery prior to drug resistance, and the path forward, including the challenges associated with developing the evidence base and implementing this paradigm into clinical care are outlined.
References
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TL;DR: Whether it is possible to diagnose specific epilepsy syndromes promptly by use of standard clinical methods, electroencephalography (EEG) and magnetic resonance imaging (MRI) and unclassified diagnosis is studied.
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