Journal ArticleDOI
Role of NO and EDHF-mediated endothelial function in the porcine pulmonary circulation: comparison between pulmonary artery and vein.
TLDR
Both NO and EDHF play an important role in regulation of porcine pulmonary arterial and venous tones and the more significant role of NO and EdHF is revealed in pulmonary arteries than in veins.About:
This article is published in Vascular Pharmacology.The article was published on 2006-03-01. It has received 20 citations till now. The article focuses on the topics: Vasodilation & Interlobular arteries.read more
Citations
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Journal ArticleDOI
Hypoxic pulmonary vasoconstriction.
TL;DR: Evidence regarding the contribution of HPV to the physiological and pathophysiological processes involved in the transition from fetal to neonatal life, pulmonary gas exchange, high-altitude pulmonary edema, and pulmonary hypertension is evaluated.
Journal ArticleDOI
What is the real physiological NO concentration in vivo
TL;DR: Three independent lines of evidence suggest the physiological NO concentration range to be 100 pM (or below) up to ∼5 nM, orders of magnitude lower than was once thought.
Journal ArticleDOI
Nitric Oxide-Dependent Feedback Loop Regulates Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Cooperativity and Endothelial Function in Small Pulmonary Arteries.
Corina Marziano,Kwangseok Hong,Eric L. Cope,Michael I. Kotlikoff,Brant E. Isakson,Swapnil K. Sonkusare +5 more
TL;DR: A novel Ca2+ signaling mechanism that regulates endothelium‐dependent vasodilation in resistance‐sized PAs is reported and it is discovered that adenosine triphosphate dilates PAs through a P2 purinergic receptor‐dependent activation of TRPV4 sparklets.
Journal ArticleDOI
Epoxyeicosatrienoic acids act through TRPV4-TRPC1-KCa1.1 complex to induce smooth muscle membrane hyperpolarization and relaxation in human internal mammary arteries
Yan Ma,Peng Zhang,Jie Li,Jun Lu,Jianjun Ge,Zhiwei Zhao,Xin Ma,Song Wan,Xiaoqiang Yao,Bing Shen,Bing Shen +10 more
TL;DR: The present study revealed that 11,12-EET targets the TRPV4-TRPC1-KCa1.1 complex to induce smooth muscle cell hyperpolarization and vascular relaxation in human LIMAs and provides novel mechanistic insights for the EET action in human LimAs.
Journal ArticleDOI
Activation of endothelial and epithelial KCa2.3 calcium‐activated potassium channels by NS309 relaxes human small pulmonary arteries and bronchioles
Christel Kroigaard,Thomas Dalsgaard,Gorm Nielsen,Britt Elmedal Laursen,Hans K. Pilegaard,Ralf Köhler,Ulf Simonsen +6 more
TL;DR: This work investigated the expression of KCa2.3 and KCa3.1 channels, and hypothesized that activation of these channels would produce relaxation of human bronchioles and pulmonary arteries.
References
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Journal ArticleDOI
Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome
TL;DR: Inhalation of nitric oxide by patients with severe adult respiratory distress syndrome reduces the pulmonary-artery pressure and increases arterial oxygenation by improving the matching of ventilation with perfusion, without producing systemic vasodilation.
Journal ArticleDOI
Observations on the Pulmonary Arterial Blood Pressure in the Cat
U. S. v. Euler,G. Liljestrand +1 more
TL;DR: The experiments seem to warrant the conclusion, that the regulation of the pulmonary blood flow is mainly mediated by a local action of the blood and alveolar gases leading to an adequate distribution of theBlood through the various parts of the lungs according to the effeciency of aeration.
Journal ArticleDOI
EDHF: bringing the concepts together.
TL;DR: Several mechanisms have been proposed to link this pivotal step to the subsequent smooth muscle hyperpolarization and the main concepts are considered in detail in this review.
Journal ArticleDOI
A transferable, beta-naphthoflavone-inducible, hyperpolarizing factor is synthesized by native and cultured porcine coronary endothelial cells.
TL;DR: The findings suggest that the vascular endothelium releases a transferable hyperpolarizing factor, chemically distinct from NO and prostacyclin, in response to agonists and mechanical stimulation.
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Difference in Endothelium-Derived Hyperpolarizing Factor–Mediated Hyperpolarization and Nitric Oxide Release Between Human Internal Mammary Artery and Saphenous Vein
Comparison of Nitric Oxide Release and Endothelium-Derived Hyperpolarizing Factor–Mediated Hyperpolarization Between Human Radial and Internal Mammary Arteries
Guo-Wei He,Zhi-Gang Liu +1 more