Journal ArticleDOI
Roles for RACK1 in cancer cell migration and invasion.
Deirdre Duff,Aideen Long +1 more
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TLDR
Accumulating evidence now demonstrates multiple roles for RACK1 in regulating migration and invasion of tumour cells, and the possibility of designing drugs that block the migratory and invasive capabilities of cancer cells represents an attractive therapeutic strategy for treating malignant disease.About:
This article is published in Cellular Signalling.The article was published on 2017-07-01. It has received 110 citations till now. The article focuses on the topics: Cell migration & Cancer cell.read more
Citations
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Tumor cell migration in complex microenvironments
TL;DR: The factors that influence tumor cell migration are discussed with a focus on the migration of transformed carcinoma cells and the development of new assays capable of applying multiple, simultaneous stimuli and imaging the cellular migratory response in real-time are focused on.
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MuRF1/TRIM63, Master Regulator of Muscle Mass.
TL;DR: This review discusses data obtained on MuRF1, both in skeletal and cardiac muscles, over the past 20 years, regarding the structure, the regulation, the location and the different functions identified, and the first inhibitors reported, and aims to draw the picture of what is known about Mu RF1.
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Mycobacterial EST12 activates a RACK1-NLRP3-gasdermin D pyroptosis-IL-1β immune pathway.
Zi-Lu Qu,Jin Zhou,Yidan Zhou,Yan Xie,Yanjing Jiang,Jian Wu,Zuoqin Luo,Guanghui Liu,Lei Yin,Xiao-Lian Zhang +9 more
TL;DR: These results provide the first proof that RACK1 acts as an endogenous host sensor for pathogens and that EST12-RACK1–induced pyroptosis plays a pivotal role in M.tb-induced immunity.
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Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation.
TL;DR: 3D imaging is used to show that elongation of the Drosophila egg chamber involves polarized cell reorientation signalled by changes in stiffness of the surrounding extracellular matrix, a mechanosensitive cellular behavior that represents a conserved mechanism that can elongate edgeless tubular epithelia in a process distinct from those that elongate bounded, planar epithelias.
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miR-92a-3p promotes the proliferation, migration and invasion of esophageal squamous cell cancer by regulating PTEN
TL;DR: The results of the study revealed that miR-92a-3p promoted the proliferation, migration and invasion of ESCC, and the effect of miR -92a -3p on ESCC was realized by regulating PTEN.
References
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The basics of epithelial-mesenchymal transition
Raghu Kalluri,Robert A. Weinberg +1 more
TL;DR: Processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias and the identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes.
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Cell migration: integrating signals from front to back.
Anne J. Ridley,Martin A. Schwartz,Keith Burridge,Richard A. Firtel,Mark H. Ginsberg,Gary G. Borisy,J. Thomas Parsons,Alan Rick Horwitz +7 more
TL;DR: The mechanisms underlying the major steps of migration and the signaling pathways that regulate them are described, and recent advances investigating the nature of polarity in migrating cells and the pathways that establish it are outlined.
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Focal adhesion kinase: in command and control of cell motility
TL;DR: A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility.
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TGF-beta-induced epithelial to mesenchymal transition.
TL;DR: The induction of EMT in response to TGF-β is discussed, and the underlying signaling and transcription mechanisms are focused on.
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PI3K/Akt signalling pathway and cancer ☆
Juan Ángel Fresno Vara,Enrique Casado,Javier de Castro,Paloma Cejas,Cristobal Belda-Iniesta,Manuel González-Barón +5 more
TL;DR: The PI3K/Akt pathway is involved in many of the mechanisms targeted by these new drugs, thus a better understanding of this crossroad can help to fully exploit the potential benefits of these new agents.