SARS-CoV-2 neutralizing antibodies after first vaccination dose in breast cancer patients receiving CDK4/6 inhibitors.
Flora Zagouri,Evangelos Terpos,Oraianthi Fiste,Michalis Liontos,Alexandros Briasoulis,Ioanna Katsiana,Efi Skafida,Christos Markellos,Elena Kunadis,Angeliki Andrikopoulou,Maria Kaparelou,Konstantinos Koutsoukos,Maria Gavriatopoulou,Efstathios Kastritis,Ioannis P. Trougakos,Meletios-Athanasios Dimopoulos +15 more
TLDR
In this article, the initial analysis of immune responses after the first dose of vaccination in 21 breast cancer patients receiving cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors was provided.About:
This article is published in The Breast.The article was published on 2021-08-28 and is currently open access. It has received 16 citations till now. The article focuses on the topics: Vaccination & Cancer.read more
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Efficacy of covid-19 vaccines in immunocompromised patients: systematic review and meta-analysis
TL;DR: In this article , the efficacy of covid-19 vaccines was compared between immunocompromised and non-immunocompensated patients. But, the results showed that a third dose of a covid19 mRNA vaccine was associated with seroconversion among vaccine nonresponders with solid cancers, haematological cancers, and immune mediated inflammatory disorders, although response was variable in transplant recipients.
Journal ArticleDOI
COVID-19 vaccines in patients with cancer: immunogenicity, efficacy and safety
Annika Fendler,Elisabeth G.E. de Vries,Corine H. GeurtsvanKessel,John B. A. G. Haanen,Bernhard Wörmann,Samra Turajlic,Marie von Lilienfeld-Toal +6 more
TL;DR: In this paper , the authors summarize the current knowledge generated in studies conducted since COVID-19 vaccines first became available and highlight critical points that might affect vaccine efficacy in patients with cancer in the future.
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Seroconversion rate after vaccination against COVID-19 in cancer patients-a systematic review.
Chiara Corti,Giuseppe Curigliano,G. Antonarelli,Florian Scotté,J-P. Spano,J. Barrière,J-M. Michot,Fabrice Andre,Giuseppe Curigliano,Giuseppe Curigliano +9 more
TL;DR: In this paper, the authors investigated the current available evidence about the immunogenicity of COVID-19 vaccines in patients with cancer, especially those receiving B-celldepleting agents in the past 12 months.
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Seroconversion rate after vaccination against COVID-19 in patients with cancer—a systematic review
TL;DR: In this paper , the authors investigated the immunogenicity of COVID-19 vaccines in patients with cancer and proposed a tailored approach to vaccination, especially on the basis of the type of malignancy and specific oncologic treatments received.
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COVID-19 Vaccination in Patients With Malignancy; A Systematic Review and Meta-Analysis of the Efficacy and Safety
Seyed Alireza Javadinia,Kimia Alizadeh,Mohammad-Shafi Mojadadi,Fatemeh Nikbakht,F. Dashti,M Joudi,Hadi Harati,James S. Welsh,Seyed Amir Farahmand,Fahimeh Attarian +9 more
TL;DR: It is concluded that vaccination against COVID-19 in patients with active malignancies using activated and inactivated vaccines is a safe and tolerable procedure that is also accompanied by a high efficacy.
References
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Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates.
Edward E. Walsh,Robert W. Frenck,Ann R. Falsey,Ann R. Falsey,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,Kathleen M. Neuzil,Mark J. Mulligan,Ruth Bailey,Kena A. Swanson,Ping Li,Kenneth Koury,Warren Kalina,David A. Cooper,Camila R. Fontes-Garfias,Pei Yong Shi,Özlem Türeci,Tompkins Kristin Rachael,Kirsten E. Lyke,Vanessa Raabe,Philip R. Dormitzer,Kathrin U. Jansen,Ugur Sahin,William C. Gruber +25 more
TL;DR: The safety and immunogenicity data from this U.S. phase 1 trial of two vaccine candidates in younger and older adults support the selection of BNT162b2 for advancement to a pivotal phase 2–3 safety and efficacy evaluation.
Journal ArticleDOI
3rd ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3)
Fatima Cardoso,Ana Costa,Elżbieta Senkus,Matti Aapro,Fabrice Andre,Carlos H. Barrios,Jonas Bergh,G. Bhattacharyya,Laura Biganzoli,Maria João Cardoso,Lisa A. Carey,D. Corneliussen-James,Giuseppe Curigliano,Véronique Diéras,N.S. El Saghir,Alex Eniu,Lesley Fallowfield,D. Fenech,Prudence A. Francis,Karen A. Gelmon,Alessandra Gennari,Nadia Harbeck,Clifford A. Hudis,Bella Kaufman,Ian E. Krop,Musa Mayer,H. Meijer,Shirley Mertz,S. Ohno,Olivia Pagani,E. Papadopoulos,Fedro A. Peccatori,Frédérique Penault-Llorca,Martine Piccart,Jean-Yves Pierga,Hope S. Rugo,Lillie D. Shockney,George W. Sledge,Sandra M Swain,Christoph Thomssen,Andrew Tutt,Daniel A. Vorobiof,Binghe Xu,Larry Norton,Eric P. Winer +44 more
TL;DR: This ESO-ESMO ABC 5 Clinical Practice Guideline provides key recommendations for managing advanced breast cancer patients, and provides updates on managing patients with all breast cancer subtypes, LABC, follow-up, palliative and supportive care.
Journal ArticleDOI
Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study.
Nicole M. Kuderer,Toni K. Choueiri,Dimpy P. Shah,Yu Shyr,Samuel M. Rubinstein,Donna R. Rivera,Sanjay Shete,Chih-Yuan Hsu,Aakash Desai,Gilberto Lopes,Petros Grivas,Petros Grivas,Corrie A. Painter,Solange Peters,Michael A. Thompson,Ziad Bakouny,Gerald Batist,Tanios Bekaii-Saab,Mehmet Asim Bilen,Nathaniel Bouganim,Mateo Bover Larroya,Daniel Castellano,Salvatore Del Prete,Deborah B. Doroshow,Pamela C Egan,Arielle Elkrief,Dimitrios Farmakiotis,Daniel Blake Flora,Matthew D. Galsky,Michael Glover,Elizabeth A. Griffiths,Anthony P. Gulati,Shilpa Gupta,Navid Hafez,Thorvardur R. Halfdanarson,Jessica Hawley,Emily Hsu,Anup Kasi,Ali Raza Khaki,Ali Raza Khaki,Christopher Lemmon,Colleen Lewis,Barbara Logan,Tyler Masters,Rana R. McKay,Ruben A. Mesa,Alicia K. Morgans,Mary F. Mulcahy,Orestis A. Panagiotou,Prakash Peddi,Nathan A. Pennell,Kerry L. Reynolds,Lane R. Rosen,Rachel P. Rosovsky,Mary Salazar,Andrew Schmidt,Sumit A. Shah,Justin Shaya,John A. Steinharter,Keith Stockerl-Goldstein,Suki Subbiah,Donald C. Vinh,Firas Wehbe,Lisa Weissmann,Julie Tsu Yu Wu,Elizabeth Marie Wulff-Burchfield,Zhuoer Xie,Albert C. Yeh,Albert C. Yeh,Peter Paul Yu,Alice Zhou,Leyre Zubiri,Sanjay Mishra,Gary H. Lyman,Gary H. Lyman,Brian I. Rini,Jeremy L. Warner,Maheen Z. Abidi,Jared D. Acoba,Neeraj Agarwal,Syed A. Ahmad,Archana Ajmera,Jessica K. Altman,Anne H. Angevine,Nilo Azad,Michael H. Bar,Aditya Bardia,Jill S. Barnholtz-Sloan,Briana Barrow,Babar Bashir,Rimma Belenkaya,Stephanie Berg,Eric H. Bernicker,Christine Bestvina,Rohit Bishnoi,Genevieve M. Boland,Mark Bonnen,Gabrielle Bouchard,Daniel W. Bowles,Fiona Busser,Angelo Cabal,Paolo Caimi,Theresa M. Carducci,Carla Casulo,James L. Chen,Jessica M. Clement,David D. Chism,Erin Cook,Catherine Curran,Ahmad Daher,Mark E. Dailey,Saurabh Dahiya,John F. Deeken,George D. Demetri,Sandy DiLullo,Narjust Duma,Rawad Elias,Bryan A. Faller,Leslie A. Fecher,Lawrence E. Feldman,Christopher R. Friese,Paul Fu,Julie Fu,Andy Futreal,Justin F. Gainor,Jorge A. Garcia,David Gill,Erin A. Gillaspie,Antonio Giordano,Grace Glace,Axel Grothey,Shuchi Gulati,Michael J. Gurley,Balazs Halmos,Roy S. Herbst,Dawn L. Hershman,Kent Hoskins,Rohit Jain,Salma K. Jabbour,Alokkumar Jha,Douglas B. Johnson,Monika Joshi,Kaitlin M. Kelleher,Jordan Kharofa,Hina Khan,Jeanna Knoble,Vadim S. Koshkin,Amit Kulkarni,Philip E. Lammers,John C. Leighton,Mark A. Lewis,X. Li,Ang Li,K. M.Steve Lo,Arturo Loaiza-Bonilla,Patricia LoRusso,Clarke A. Low,Maryam B. Lustberg,Daruka Mahadevan,Abdul Hai Mansoor,Michelle Marcum,Merry Jennifer Markham,Catherine Handy Marshall,Sandeep H. Mashru,Sara Matar,Christopher McNair,Shannon K. McWeeney,Janice M. Mehnert,Alvaro G. Menendez,Harry Menon,Marcus Messmer,Ryan Monahan,Sarah Mushtaq,Gayathri Nagaraj,Sarah Nagle,Jarushka Naidoo,John M. Nakayama,Vikram M. Narayan,Heather H. Nelson,Eneida R. Nemecek,Ryan Nguyen,Pier Vitale Nuzzo,Paul E. Oberstein,Adam J. Olszewski,Susie Owenby,Mary M. Pasquinelli,John Philip,Sabitha Prabhakaran,Matthew Puc,Amelie G. Ramirez,Joerg Rathmann,Sanjay G. Revankar,Young Soo Rho,Terence Duane Rhodes,Robert L. Rice,Gregory J. Riely,Jonathan Riess,Cameron Rink,Elizabeth Robilotti,Lori J. Rosenstein,Bertrand Routy,Marc A. Rovito,M. Wasif Saif,Amit Sanyal,Lidia Schapira,Candice Schwartz,Oscar K. Serrano,Mansi R. Shah,Chintan Shah,Grace Shaw,Ardaman Shergill,Geoffrey Shouse,Heloisa P. Soares,Carmen C. Solorzano,Pramod K. Srivastava,Karen Stauffer,Daniel G. Stover,Jamie Stratton,Catherine Stratton,Vivek Subbiah,Rulla M. Tamimi,Nizar M. Tannir,Umit Topaloglu,Eli Van Allen,Susan Van Loon,Karen Vega-Luna,Neeta K. Venepalli,Amit Verma,Praveen Vikas,Sarah Wall,Paul L. Weinstein,Matthias Weiss,Trisha Wise-Draper,William A. Wood,Wenxin Xu,Susan Yackzan,Rosemary Zacks,Tian Zhang,Andrea J. Zimmer,Jack West +239 more
TL;DR: The outcomes of a cohort of patients with cancer and COVID-19 are characterised and potential prognostic factors for mortality and severe illness are identified and race and ethnicity, obesity status, cancer type, type of anticancer therapy, and recent surgery were not associated with mortality.
Journal ArticleDOI
Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study.
Leticia Monin,Adam Laing,Miguel Muñoz-Ruiz,Duncan R. McKenzie,Irene del Molino del Barrio,Irene del Molino del Barrio,Thanussuyah Alaguthurai,Clara Domingo-Vila,Thomas Hayday,Carl Graham,Jeffrey Seow,Sultan Abdul-Jawad,Shraddha Kamdar,Elizabeth Harvey-Jones,Rosalind Graham,Jack Cooper,Muhammad Shamim Khan,Jennifer Vidler,Helen Kakkassery,Shubhankar Sinha,Richard Davis,Liane Dupont,Isaac Francos Quijorna,Charlotte O'Brien-Gore,Puay Ling Lee,Josephine Eum,Maria Conde Poole,Magdalene Joseph,Daniel Davies,Daniel Davies,Yin Wu,Angela Swampillai,Bernard V. North,Ana Montes,Mark Harries,Anne Rigg,James Spicer,James Spicer,Michael H. Malim,Paul Fields,Paul Fields,Piers E.M. Patten,Piers E.M. Patten,Francesca Di Rosa,Sophie Papa,Sophie Papa,Timothy Tree,Katie J. Doores,Adrian Hayday,Adrian Hayday,Sheeba Irshad,Sheeba Irshad +51 more
TL;DR: In this paper, the safety and immunogenicity of the BNT162b2 (Pfizer-BioNTech) vaccine in patients with cancer was evaluated using data from three London hospitals between Dec 8, 2020 and Feb 18, 2021.
Journal ArticleDOI
Looking beyond COVID-19 vaccine phase 3 trials.
TL;DR: In this paper, a comprehensive post-efficacy strategy for the next steps to ensure vaccination of the global population is now required, including how to manufacture billions of doses of high-quality vaccines, support for vaccine purchase, coordination of supply, equitable distribution of vaccines and the logistics of global vaccine delivery, all of which are a prelude to a massive vaccination campaign targeting people of all ages.