Sequential MyD88-Independent and -Dependent Activation of Innate Immune Responses to Intracellular Bacterial Infection
Natalya V. Serbina,William A. Kuziel,Richard A. Flavell,Shizuo Akira,Barrett J. Rollins,Eric G. Pamer +5 more
TLDR
The results indicate that distinct microbial signals activate innate immune responses in an ordered, step-wise fashion, providing a mechanism to specify and modulate antimicrobial effector functions.About:
This article is published in Immunity.The article was published on 2003-12-01 and is currently open access. It has received 216 citations till now. The article focuses on the topics: Monocyte & Chemokine.read more
Citations
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Journal ArticleDOI
Toll-like receptor signalling
Shizuo Akira,Kiyoshi Takeda +1 more
TL;DR: Rapid progress that has recently improved the understanding of the molecular mechanisms that mediate TLR signalling is reviewed.
Journal ArticleDOI
Monocyte recruitment during infection and inflammation
Chao Shi,Eric G. Pamer +1 more
TL;DR: The mechanisms that control monocyte trafficking under homeostatic, infectious and inflammatory conditions are being unravelled and are the focus of this Review.
Journal ArticleDOI
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.
TL;DR: This review discusses major advances in the understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.
Journal ArticleDOI
Blood monocytes: development, heterogeneity, and relationship with dendritic cells.
TL;DR: Functional characterization of monocytes is in progress in humans and rodents and will provide a better understanding of the pathophysiology of inflammation.
Journal ArticleDOI
Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
Natalya V. Serbina,Eric G. Pamer +1 more
TL;DR: In blood, Ccr2−/− monocytes could traffic to sites of infection, demonstrating that CCR2 is not required for migration from the circulation into tissues, and determining the frequency of Ly6Chi monocytes in the circulation.
References
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Toll-like receptors.
TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
Journal ArticleDOI
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
Osamu Takeuchi,Katsuaki Hoshino,Taro Kawai,Hideki Sanjo,Haruhiko Takada,Tomohiko Ogawa,Kiyoshi Takeda,Shizuo Akira +7 more
TL;DR: It is demonstrated that TLR2 and TLR4 recognize different bacterial cell wall components in vivo andTLR2 plays a major role in Gram-positive bacterial recognition.
Journal ArticleDOI
Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function
Osamu Adachi,Taro Kawai,Kiyoshi Takeda,Makoto Matsumoto,Hiroko Tsutsui,Masafumi Sakagami,Kenji Nakanishi,Shizuo Akira +7 more
TL;DR: It is demonstrated that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor, and increases in interferon-gamma production and natural killer cell activity in response to IL- 18 are abrogated.
Journal ArticleDOI
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.
Klaus Pfeffer,Toshifumi Matsuyama,Thomas M. Kündig,Andrew Wakeham,Kenji Kishihara,Arda Shahinian,Katja Wiegmann,Pamela S. Ohashi,Martin Krönke,Tak W. Mak +9 more
TL;DR: The TNFRp55 function renders mice resistant to lethal dosages of either lipopolysaccharides or S. aureus enterotoxin B, and the 55 kd TNFR plays a decisive role in the host's defense against microorganisms and their pathogenic factors.
Journal ArticleDOI
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme
Keisuke Kuida,Judith A. Lippke,George Ku,Matthew W. Harding,David J. Livingston,Michael S.-S. Su,Richard A. Flavell +6 more
TL;DR: Thymocytes from ICE-/- mice were sensitive to apoptosis induced by dexamethasone or ionizing radiation, but were resistant to apoptoses induced by Fas antibody, despite this defect in apoptosis.
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Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
Natalya V. Serbina,Eric G. Pamer +1 more