Journal ArticleDOI
Serum irisin levels in new-onset type 2 diabetes
Yeon-Kyung Choi,Mi-Kyung Kim,Kwi Hyun Bae,Hyun-Ae Seo,Ji-Yun Jeong,Won-Kee Lee,Jung-Guk Kim,Inkyu Lee,Keun-Gyu Park +8 more
TLDR
It is found that serum irisin levels were decreased in T1D patients and inversely associated with newly diagnosed T2D, suggesting that irisin may play a crucial role in glucose intolerance and T2 D.About:
This article is published in Diabetes Research and Clinical Practice.The article was published on 2013-04-01. It has received 375 citations till now. The article focuses on the topics: FNDC5 & Myokine.read more
Citations
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Journal ArticleDOI
Irisin Stimulates Browning of White Adipocytes through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling
Yuan Zhang,Rui Li,Yan Meng,Shiwu Li,William Donelan,Yan Zhao,Lei Qi,Mingxiang Zhang,Xingli Wang,Taixing Cui,Taixing Cui,Li-Jun Yang,Dongqi Tang,Dongqi Tang +13 more
TL;DR: The data suggest that irisin can potentially prevent obesity and associated type 2 diabetes by stimulating expression of WAT browning-specific genes via the p38 MAPK and ERK pathways.
Journal ArticleDOI
The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans.
Frode Norheim,Torgrim Mikal Langleite,Marit Hjorth,Torgeir Holen,Anders Kielland,Hans Kristian Stadheim,Hanne L. Gulseth,Kåre I. Birkeland,Kåre I. Birkeland,Jørgen Jensen,Christian A. Drevon +10 more
TL;DR: No enhancing effect of long‐term training on circulating irisin levels, and little or no effect of training on browning of subcutaneous white adipose tissue in humans is observed.
Journal ArticleDOI
Circulating Irisin in Relation to Insulin Resistance and the Metabolic Syndrome
Kyung Hee Park,Lesya Zaichenko,Mary Brinkoetter,Bindiya Thakkar,Ayse Sahin-Efe,Ayse Sahin-Efe,Kyoung Eun Joung,Michael A. Tsoukas,Eleni Geladari,Joo Young Huh,Fadime Dincer,Cynthia Davis,Judith A. Crowell,Christos S. Mantzoros,Christos S. Mantzoros +14 more
TL;DR: Irisin is associated with increased risk of MetS, cardiometabolic variables, and CVD in humans, indicating either increased secretion by adipose/muscle tissue and/or a compensatory increase of irisin to overcome an underlying irisin resistance in these subjects.
Journal ArticleDOI
Physiology and role of irisin in glucose homeostasis
Nikolaos Perakakis,Georgios Triantafyllou,José Manuel Fernández-Real,Joo Young Huh,Kyung Hee Park,Jochen Seufert,Christos S. Mantzoros,Christos S. Mantzoros +7 more
TL;DR: This Review presents the current knowledge on the physiology of irisin and its role in glucose homeostasis, and describes the mechanisms involved in the synthesis, secretion, circulation and regulation of irisin, and the controversies regarding the measurement.
Journal ArticleDOI
Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies
Timea Kurdiova,Miroslav Balaz,Marek Vician,Denisa Maderova,Miroslav Vlcek,Ladislav Valkovič,Miroslav Srbecky,Richard Imrich,Olga Kyselovicova,Vitazoslav Belan,Ivan Jelok,Christian Wolfrum,Iwar Klimes,Martin Krššák,Erika Zemková,Daniela Gasperikova,Jozef Ukropec,Barbara Ukropcova,Barbara Ukropcova +18 more
TL;DR: In this paper, the authors explored Fndc5 gene and irisin protein in two clinical studies: (i) a cross-sectional study (effects of type 2 diabetes (T2D) in drug-naive men and (ii) an intervention study (exercise effects in sedentary, overweight/obese individuals).
References
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A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation
TL;DR: The purpose of this study was to develop an equation from MDRD Study data that could improve the prediction of GFR from serum creatinine concentration, and major clinical decisions in general medicine, geriatrics, and oncology are made by using the Cockcroft-Gault formula and other formulas to predict the level of renal function.
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Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults : the evidence report
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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Pontus Boström,Jun Wu,Mark P. Jedrychowski,Anisha Korde,Li Ye,James C. Lo,Kyle A. Rasbach,Elisabeth A. Boström,Jang Hyun Choi,Jonathan Z. Long,Shingo Kajimura,Maria Cristina Zingaretti,Birgitte F. Vind,Hua Tu,Saverio Cinti,Kurt Højlund,Steven P. Gygi,Bruce M. Spiegelman +17 more
TL;DR: This article showed that PGC1α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin.
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Obesity and Diabetes in the Developing World — A Growing Challenge
TL;DR: Propelling an upsurge in cases of diabetes and hypertension is the growing prevalence of overweight and obesity.
Journal ArticleDOI
Muscles, exercise and obesity: skeletal muscle as a secretory organ
TL;DR: The finding that the muscle secretome consists of several hundred secreted peptides provides a conceptual basis and a whole new paradigm for understanding how muscles communicate with other organs, such as adipose tissue, liver, pancreas, bones and brain.