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Open AccessJournal ArticleDOI

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges.

Chih-Cheng Lai, +4 more
- 17 Feb 2020 - 
- Vol. 55, Iss: 3, pp 105924-105924
TLDR
Among patients with pneumonia caused by SARS-CoV-2 (novel coronavirus pneumonia or Wuhan pneumonia), fever was the most common symptom, followed by cough, and bilateral lung involvement with ground-glass opacity was themost common finding from computed tomography images of the chest.
About: 
This article is published in International Journal of Antimicrobial Agents.The article was published on 2020-02-17 and is currently open access. It has received 4318 citations till now. The article focuses on the topics: Pneumonia & Outbreak.

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Citations
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Journal ArticleDOI

Generating randomized trial evidence to optimize treatment in the COVID-19 pandemic.

Matthew P. Cheng, +3 more
- 14 Apr 2020 - 
TL;DR: While aggressive mitigation strategies are being implemented to slow the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there must also strive to optimize clinical outcomes for those infected and prevent transmission among their close contacts.
Journal ArticleDOI

Analytical Sensitivity and Specificity of Two RT-qPCR Protocols for SARS-CoV-2 Detection Performed in an Automated Workflow

Gustavo Barcelos Barra, +4 more
- 12 Oct 2020 - 
TL;DR: Investigation of the analytical performance of two interim RT-qPCR protocols for the qualitative detection of SARS-CoV-2 executed in a fully automated platform finds that N1, E, and a modified version of RdRP assays presented adequate analytical specificity, amplification efficiency, and analytical sensitivity using contrived samples.
Journal ArticleDOI

Is there a role for blood purification therapies targeting cytokine storm syndrome in critically severe COVID-19 patients?

Gang Chen, +5 more
- 22 May 2020 - 
TL;DR: The different aspects of blood purification in critically ill patients with AKI and increased inflammatory factors, and the high-throughput membrane with adsorption function and cytokine Adsorption column are two representatives of recently emerging novel membrane technologies that have potential in removing inflammatory factors and other toxins prospects for the treatment of severe COVID-19.
Journal ArticleDOI

Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy.

Thanigaimalai Pillaiyar, +1 more
- 03 Jun 2021 - 
TL;DR: In this paper, the authors highlight kinases that are associated with coronavirus infections and their inhibitors with antiviral and potentially anti-inflammatory, cytokine-suppressive, or antifibrotic activity.
Journal ArticleDOI

Possible SARS-coronavirus 2 inhibitor revealed by simulated molecular docking to viral main protease and host toll-like receptor

Xiaopeng Hu, +8 more
- 12 Jun 2020 - 
TL;DR: Rutin may influence viral functional protein assembly and host inflammatory suppression and its affinity for Mpro and TLRs render rutin a potential novel therapeutic anti-coronavirus strategy.
References
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Journal ArticleDOI

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang, +28 more
- 24 Jan 2020 - 
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI

A Novel Coronavirus from Patients with Pneumonia in China, 2019.

Na Zhu, +18 more
- 24 Jan 2020 - 
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou, +28 more
- 03 Feb 2020 - 
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.

Dawei Wang, +13 more
- 17 Mar 2020 - 
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

Nanshan Chen, +13 more
- 30 Jan 2020 - 
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

Nanshan Chen, +13 more
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.

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A Novel Coronavirus from Patients with Pneumonia in China, 2019.

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Clinical Characteristics of Coronavirus Disease 2019 in China.

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