Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges.
TLDR
Among patients with pneumonia caused by SARS-CoV-2 (novel coronavirus pneumonia or Wuhan pneumonia), fever was the most common symptom, followed by cough, and bilateral lung involvement with ground-glass opacity was themost common finding from computed tomography images of the chest.Citations
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Probiotic-Based Vaccines May Provide Effective Protection against COVID-19 Acute Respiratory Disease
Sedigheh Taghinezhad-S,Amir Hossein Mohseni,Luis G. Bermúdez-Humarán,Vincenzo Casolaro,Naima G. Cortes-Perez,Hossein Keyvani,Jesus Simal-Gandara +6 more
TL;DR: In this article, the authors highlight the existing pre-clinical and clinical information on the use of genetically modified microorganisms in control strategies against respiratory and non-respiratory viruses.
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Caffeine and caffeine-containing pharmaceuticals as promising inhibitors for 3-chymotrypsin-like protease of SARS-CoV-2.
TL;DR: This in silico study shows for the first time very inexpensive drugs available in large quantities that can be potential inhibitors against 3CLpro and suggests the repurposing of linagliptin, and caffeine are recommended for COVID-19 treatment.
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The Evolutionary Landscape of SARS-CoV-2 Variant B.1.1.519 and Its Clinical Impact in Mexico City
Alberto Cedro-Tanda,Laura Gómez-Romero,Nicolas Alcaraz,Guillermo de Anda-Jáuregui,Fernando Peñaloza,Bernardo Moreno,Marco A Escobar-Arrazola,Oscar A Ramirez-Vega,Paulina Munguia-Garza,Francisco Garcia-Cardenas,Mireya Cisneros-Villanueva,José L. Moreno-Camacho,Jorge Rodriguez-Gallegos,Marco A. Luna-Ruiz Esparza,Miguel A Fernández Rojas,Alfredo Mendoza-Vargas,Juan Pablo Reyes-Grajeda,Abraham Campos-Romero,Ofelia Angulo,Rosaura Ruiz,Claudia Sheinbaum-Pardo,Jose Sifuentes-Osornio,David Kershenobich,Alfredo Hidalgo-Miranda,Luis A. Herrera +24 more
TL;DR: In this paper, the authors reported the emergence of SARS-CoV-2 variant B.1.519 in Mexico City and presented evidence of its geographical origin based on phylogenetic analysis.
Learning in the Age of SARS-COV-2: A Quantitative Study of Learners’ Performance in the Age of Emergency Remote Teaching
TL;DR: The authors found that students' sense of responsibility was enhanced by the emergency remote teaching state, which was not negatively affected when students faced Emergency Remote Teaching (ERT), and experimental groups who transitioned to ERT performed better than control groups.
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Dynamic Panel Estimate-Based Health Surveillance of SARS-CoV-2 Infection Rates to Inform Public Health Policy: Model Development and Validation.
TL;DR: DPD models successfully correct for measurement error and data contamination and are useful to derive surveillance metrics and corroborates the hypothesis that economic reopening without applying best public health practices is associated with a resurgence of the pandemic.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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