Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges.
TLDR
Among patients with pneumonia caused by SARS-CoV-2 (novel coronavirus pneumonia or Wuhan pneumonia), fever was the most common symptom, followed by cough, and bilateral lung involvement with ground-glass opacity was themost common finding from computed tomography images of the chest.Citations
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The role of dysregulated immune responses in COVID-19 pathogenesis.
Sahar Tahaghoghi-Hajghorbani,Parisa Zafari,Elham Masoumi,Misagh Rajabinejad,Reza Jafari-Shakib,B Hasani,Alireza Rafiei +6 more
TL;DR: The differences between the immune responses of the lung in children and adults, immune dysregulation and their possible role in clinical manifestations in COVID-19 are highlighted.
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A mechanism-based parameterisation scheme to investigate the association between transmission rate of COVID-19 and meteorological factors on plains in China.
Changqing Lin,Alexis K.H. Lau,Jimmy Chi Hung Fung,Cui Guo,Jimmy W.M. Chan,David W. Yeung,Yumiao Zhang,Yacong Bo,Shakhaoat Hossain,Yiqian Zeng,Xiang Qian Lao +10 more
TL;DR: Findings suggest that the mitigation of COVID-19 spread in densely populated and/or cold regions will be a great challenge.
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Spatio-temporal propagation of COVID-19 pandemics
Bnaya Gross,Zhiguo Zheng,Shiyan Liu,Xiaoqi Chen,Alon Sela,Jianxin Li,Daqing Li,Shlomo Havlin +7 more
TL;DR: The spatio-temporal propagation of the COVID-19 virus in China is compared to other global locations and suggests that the disease propagation is highly related to population migration from Hubei resembling a Lévy flight which is characteristic of human mobility and thus could be controlled by efficient quarantines.
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Efficacy and safety of herbal medicine (Lianhuaqingwen) for treating COVID-19: A systematic review and meta-analysis.
TL;DR: H combined with conventional treatment seems to be more effective for patients with mild or ordinary COVID-19, and the rate of abnormal liver function in the combined medication group is higher than that in the single LH group.
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Update on therapeutic approaches and emerging therapies for SARS-CoV-2 virus.
Calvin A. Omolo,Calvin A. Omolo,Nikki Soni,Victoria Oluwaseun Fasiku,Irene Mackraj,Thirumala Govender +5 more
TL;DR: This review describes the proposed drug targets for therapy, and outcomes of clinical trials that have been reported, and identifies the adopted treatment modalities that are showing promise, and those that have failed as drug candidates.
References
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Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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