Signaling to p53: ribosomal proteins find their way.
Yanping Zhang,Hua Lu +1 more
TLDR
The ribosomal protein-MDM2-p53 signaling pathway provides a molecular switch that may constitute a surveillance network monitoring the integrity of Ribosomal biogenesis.About:
This article is published in Cancer Cell.The article was published on 2009-11-03 and is currently open access. It has received 489 citations till now. The article focuses on the topics: Ribosomal protein & Ribosome biogenesis.read more
Citations
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Journal ArticleDOI
The Nucleolus under Stress
TL;DR: Nucleolar function in the stress-induced regulation of p53 and the specific changes in nucleolar morphology and composition that occur upon stress are reviewed.
Journal ArticleDOI
Specialized ribosomes: a new frontier in gene regulation and organismal biology
Shifeng Xue,Maria Barna +1 more
TL;DR: The hypothesis that intrinsic regulation by the ribosome acts to selectively translate subsets of mRNAs harbouring unique cis-regulatory elements, thereby introducing an additional level of regulation in gene expression and the life of an organism is discussed.
Journal ArticleDOI
Ribosomal proteins: functions beyond the ribosome
TL;DR: The current understanding of how ribosomal stress provokes the accumulation of ribosome-free Ribosomal proteins, as well as the ribosomesome-independent functions of ribOSomal proteins in tumorigenesis, immune signaling, and development are overviewed.
Journal ArticleDOI
Ribosome biogenesis in cancer: new players and therapeutic avenues
TL;DR: The most recent findings that provide new insights into the molecular basis of ribosome biogenesis in cancer are highlighted and the perspective on how these observations present opportunities for the design of new targeted cancer treatments is offered.
Journal ArticleDOI
Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma
Siyuan Zheng,Andrew D. Cherniack,Andrew D. Cherniack,Ninad Dewal,Richard A. Moffitt,Ludmila Danilova,Bradley A. Murray,Bradley A. Murray,Antonio M. Lerario,Antonio M. Lerario,Tobias Else,Theo A. Knijnenburg,Giovanni Ciriello,Giovanni Ciriello,Seungchan Kim,Guillaume Assié,Olena Morozova,Rehan Akbani,Juliann Shih,Juliann Shih,Katherine A. Hoadley,Toni K. Choueiri,Toni K. Choueiri,Jens Waldmann,Ozgur Mete,A.G. Robertson,Hsin-Ta Wu,Benjamin J. Raphael,Shao L,Matthew Meyerson,Matthew Meyerson,Michael J. Demeure,Felix Beuschlein,Anthony J. Gill,Anthony J. Gill,Stan B. Sidhu,Stan B. Sidhu,Madson Q. Almeida,Maria Candida Barisson Villares Fragoso,Leslie Cope,Electron Kebebew,Mouhammed Amir Habra,Timothy G. Whitsett,Kimberly J. Bussey,Kimberly J. Bussey,William E. Rainey,Sylvia L. Asa,Jérôme Bertherat,Martin Fassnacht,David A. Wheeler,Gary D. Hammer,Thomas J. Giordano,Roeland Verhaak +52 more
TL;DR: Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers.
References
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Journal ArticleDOI
Surfing the p53 network
TL;DR: The p53 tumour-suppressor gene integrates numerous signals that control cell life and death, and the disruption of p53 has severe consequences when a highly connected node in the Internet breaks down.
Journal ArticleDOI
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Lyubomir T. Vassilev,Binh Thanh Vu,Bradford Graves,Daisy Carvajal,Frank John Podlaski,Zoran Filipovic,Norman Kong,Ursula Kammlott,Christine Lukacs,Christian Klein,Nader Fotouhi,Liu Emily Aijun +11 more
TL;DR: In this article, the authors identify potent and selective small-molecule antagonists of MDM2 and confirm their mode of action through the crystal structures of complexes, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts.
Journal ArticleDOI
Mdm2 promotes the rapid degradation of p53
TL;DR: It is proposed that the Mdm2-promoted degradation of p53 provides a new mechanism to ensure effective termination of the p53 signal.
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Regulation of p53 stability by Mdm2
TL;DR: It is shown that interaction with Mdm2 can also result in a large reduction in p53 protein levels through enhanced proteasome-dependent degradation, which may contribute to the maintenance of low p53 concentrations in normal cells.
Journal ArticleDOI
Live or let die: the cell's response to p53
Karen H. Vousden,Xin Lu +1 more
TL;DR: Understanding the complex mechanisms that regulate whether or not a cell dies in response to p53 will ultimately contribute to the development of therapeutic strategies to repair the apoptotic p53 response in cancers.
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