Journal ArticleDOI
Single-strand break repair and genetic disease
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TLDR
The molecular mechanisms and organization of the DNA-repair pathways that remove single-strand breaks are reviewed and the connection between defects in these pathways and hereditary neurodegenerative disease are discussed.Abstract:
Hereditary defects in the repair of DNA damage are implicated in a variety of diseases, many of which are typified by neurological dysfunction and/or increased genetic instability and cancer. Of the different types of DNA damage that arise in cells, single-strand breaks (SSBs) are the most common, arising at a frequency of tens of thousands per cell per day from direct attack by intracellular metabolites and from spontaneous DNA decay. Here, the molecular mechanisms and organization of the DNA-repair pathways that remove SSBs are reviewed and the connection between defects in these pathways and hereditary neurodegenerative disease are discussed.read more
Citations
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Tissue-Specific Carcinogens as Soil to Seed BRCA1/2-Mutant Hereditary Cancers
Anup Kumar Singh,Xiaochun Yu +1 more
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From green to red – To more dead? Autofluorescent proteins as photosensitizers
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Enhanced DNA repair of bleomycin-induced 3′-phosphoglycolate termini at the transcription start sites of actively transcribed genes in human cells
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Patent
Editing of CCR5 receptor gene to protect against HIV infection
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Antileukemic Efficacy in Vitro of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies
Vanessa Kohl,Johanna Flach,Nicole Naumann,Susanne Brendel,Helga Kleiner,Christel Weiss,Wolfgang Seifarth,Daniel Nowak,Wolf-Karsten Hofmann,Alice Fabarius,Henning D. Popp +10 more
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References
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TL;DR: It is demonstrated that one function of (ADP–ribose)n is to participate in the cellular recovery from DNA damage, and specific inhibitors of poly(ADP-ribose] polymerase prevent rejoining of DNA strand breaks caused by dimethyl sulphate and cytotoxicity is enhanced thereby.
Journal ArticleDOI
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TL;DR: This work has shown the ability to characterize the sugar moiety through the mechanism of “sugar-by-sugar interactions” and has suggested a number of mechanisms that could be responsible for the sweetness of the sucrose molecule.