Journal ArticleDOI
Single-strand break repair and genetic disease
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TLDR
The molecular mechanisms and organization of the DNA-repair pathways that remove single-strand breaks are reviewed and the connection between defects in these pathways and hereditary neurodegenerative disease are discussed.Abstract:
Hereditary defects in the repair of DNA damage are implicated in a variety of diseases, many of which are typified by neurological dysfunction and/or increased genetic instability and cancer. Of the different types of DNA damage that arise in cells, single-strand breaks (SSBs) are the most common, arising at a frequency of tens of thousands per cell per day from direct attack by intracellular metabolites and from spontaneous DNA decay. Here, the molecular mechanisms and organization of the DNA-repair pathways that remove SSBs are reviewed and the connection between defects in these pathways and hereditary neurodegenerative disease are discussed.read more
Citations
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Journal ArticleDOI
Investigating Molecular Determinants of Cancer Cell Resistance to Ionizing Radiation Through an Integrative Bioinformatics Approach.
Halil Ibrahim Toy,Gökhan Karakülah,Panagiota I. Kontou,Hani Alotaibi,Alexandros G. Georgakilas,Athanasia Pavlopoulou +5 more
TL;DR: In this article, an integrative bioinformatics approach was applied to three publicly available RNA sequencing and microarray transcriptome datasets of human cancer cells of different tissue origins treated with ionizing radiation.
Posted ContentDOI
NickSeq for genome-wide strand-specific identification of DNA single-strand break sites with single nucleotide resolution
Joshua J Elacqua,Joshua J Elacqua,Navpreet Ranu,Navpreet Ranu,Sarah E. Dilorio,Sarah E. Dilorio,Sarah E. Dilorio,Paul C. Blainey,Paul C. Blainey +8 more
TL;DR: A new method is developed, NickSeq, for efficient strand-specific profiling of nicks in complex DNA samples with single nucleotide resolution and low false-positive rates and will be useful in exploring the relevance of spontaneously occurring or repair-induced DNA breaks in human disease, DNA breaks caused by DNA damaging agents including therapeutics, and the activity of engineered nucleases in genome editing and other biotechnological applications.
Journal ArticleDOI
New insights into the prevention and treatment of familial breast cancer.
TL;DR: DNA damaging agents, like cisplatin, and the new class of drugs called PARP inhibitors exploit the underlying defect in DNA damage repair to great effect.
Journal ArticleDOI
Protective Mechanisms Against DNA Replication Stress in the Nervous System
TL;DR: Both cell-autonomous mechanisms, as well as the evidence of RSR-mediated alterations of the cellular microenvironment in the nervous system, were discussed.
Journal ArticleDOI
DNA Damage and Repair in Migraine: Oxidative Stress and Beyond
TL;DR: In conclusion, aberrant activity of SSBR evoked by compromised PARP-1 and XRCC1 may contribute to pathological phenomena in the migraine brain.
References
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Journal ArticleDOI
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