SIRT1 provides new pharmacological targets for polydatin through its role as a metabolic sensor.
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TLDR
In this paper, a review summarizes the signaling mechanism of polydatin involving SIRT1 and discusses the roles of related signal molecules such as PGC-1α, Nrf2, p38-MAPK, NLPR3 inflammasome, and p53.About:
This article is published in Biomedicine & Pharmacotherapy.The article was published on 2021-04-23 and is currently open access. It has received 14 citations till now.read more
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Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives.
TL;DR: Wang et al. as discussed by the authors summarized the pharmacological actions of active ingredients from frequently used single herbs in TCM compounds and explored their comprehensive effects on NAFLD. But, the multi-compounds and multi-targets are big obstacle for the study of TCM.
Journal ArticleDOI
Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits
TL;DR: The therapeutic targets, biological activities, pharmacological mechanisms, and health benefits of polydatin are reviewed to provide new insights to researchers and the need to develop further clinical trials and novel delivery systems is considered.
Journal ArticleDOI
Lycium barbarum Extracts Extend Lifespan and Alleviate Proteotoxicity in Caenorhabditis elegans
Haitao Zhou,Shanshan Ding,Chuanxin Sun,Jiahui Fu,Dong Yang,Xi'e Wang,Chih-chen Wang,Lei Wang +7 more
TL;DR: This study reported that total water extracts of L. barbarum berry extended lifespan and alleviated toxic protein aggregation in neurodegenerative worms with hsf-1 deficiency and suggested that LBE may be a potential antiaging natural dietary supplement especially to individuals with malnutrition or chronic diseases.
Journal ArticleDOI
Targeting long non coding RNA by natural products: Implications for cancer therapy.
TL;DR: In this paper, the effect of various phytochemicals on regulation of long non-coding RNAs in different human cancer and evaluate their capabilities for cancer treatment and prevention was investigated.
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[Polydatin improves intestinal barrier injury after traumatic brain injury in rats by reducing oxidative stress and inflammatory response via activating SIRT1-mediated deacetylation of SOD2 and HMGB1].
TL;DR: PD alleviates oxidative stress and inflammatory response by activating Sirt1-mediated deacetylation of SOD2 and HMGB1 to improve intestinal mucosal injury in TBI rats.
References
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AMPK regulates energy expenditure by modulating NAD + metabolism and SIRT1 activity
Carles Cantó,Zachary Gerhart-Hines,Jerome N. Feige,Marie Lagouge,Liliana Noriega,Liliana Noriega,Jill C. Milne,Peter J. Elliott,Pere Puigserver,Johan Auwerx,Johan Auwerx +10 more
TL;DR: It is demonstrated that AMPK controls the expression of genes involved in energy metabolism in mouse skeletal muscle by acting in coordination with another metabolic sensor, the NAD+-dependent type III deacetylase SIRT1.
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Mechanisms and functions of p38 MAPK signalling
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