Journal ArticleDOI
Spontaneous and therapeutic prognostic factors in adult hemispheric World Health Organization Grade II gliomas: a series of 1097 cases: clinical article.
Laurent Capelle,Denys Fontaine,Emmanuel Mandonnet,Luc Taillandier,Jean Louis Golmard,Luc Bauchet,Johan Pallud,Philippe Peruzzi,Marie Hélène Baron,Michèle Kujas,Jacques Guyotat,Remi Guillevin,Marc Frenay,Sophie Taillibert,Philippe Colin,Valérie Rigau,F. Vandenbos,Catherine Pinelli,Hugues Duffau,French Réseau d'Étude des Gliomes +19 more
TLDR
This large series with its volumetric assessment refines the prognostic value of previously stressed clinical and radiological parameters and highlights the importance of tumor size and location.Abstract:
Object The spontaneous prognostic factors and optimal therapeutic strategy for WHO Grade II gliomas (GIIGs) have yet to be unanimously defined. Specifically, the role of resection is still debated, most notably because the actual amount of resection has seldom been assessed. Methods Cases of GIIGs treated before December 2007 were extracted from a multicenter database retrospectively collected since January 1985 and prospectively collected since 1996. Inclusion criteria were a patient age ≥ 18 years at diagnosis, histological diagnosis of WHO GIIG, and MRI evaluation of tumor volume at diagnosis and after initial surgery. One thousand ninety-seven lesions were included in the analysis. The mean follow-up was 7.4 years since radiological diagnosis. Factors significant in a univariate analysis (with a p value ≤ 0.1) were included in the multivariate Cox proportional hazard regression model analysis. Results At the time of radiological diagnosis, independent spontaneous factors of a poor prognosis were an ag...read more
Citations
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Journal ArticleDOI
Extent of Resection in Glioma-A Review of the Cutting Edge.
TL;DR: The neurosurgical community has made a large effort to define the clinical benefits of maximizing tumor resection, with particular attention paid to the ever-evolving understanding of glioma molecular heterogeneity.
Journal ArticleDOI
Characterization of a Raman spectroscopy probe system for intraoperative brain tissue classification.
Joannie Desroches,Michael Jermyn,Kelvin Mok,Cedric Lemieux-Leduc,Jeanne Mercier,Karl St-Arnaud,Kirk Urmey,Marie-Christine Guiot,Eric Marple,Kevin Petrecca,Frederic Leblond +10 more
TL;DR: In vivo Raman spectra were measured, demonstrating that real-time inelastic scattering measurements can distinguish necrosis from vital tissue (including tumor and normal brain tissue) with an accuracy of 87%, a sensitivity of 84% and a specificity of 89%.
Journal ArticleDOI
Functional preoperative and intraoperative mapping and monitoring: increasing safety and efficacy in glioma surgery.
TL;DR: Functional localization of eloquent cortex or subcortical fiber tracts can enhance the EOR and functional outcome, and tailored pre- and intraoperative mapping and monitoring can be maximized, with reduced rates of surgery-related deficits.
Journal ArticleDOI
Residual Tumor Volume as Best Outcome Predictor in Low Grade Glioma – A Nine-Years Near-Randomized Survey of Surgery vs. Biopsy
Roland Roelz,David Strohmaier,Ramazan Jabbarli,Rainer Kraeutle,Karl Egger,Volker A. Coenen,Astrid Weyerbrock,Peter C. Reinacher +7 more
TL;DR: Maximum safe resection is the first therapy of choice in DLGG patients if a near-complete tumor removal can be achieved and accurate prediction of the extent-of-resection is required for selection of surgical candidates.
Journal ArticleDOI
Combined noninvasive language mapping by navigated transcranial magnetic stimulation and functional MRI and its comparison with direct cortical stimulation.
Sebastian Ille,Nico Sollmann,Theresa Hauck,Stefanie Maurer,Noriko Tanigawa,Thomas Obermueller,Chiara Negwer,Doris Droese,Claus Zimmer,Bernhard Meyer,Florian Ringel,Sandro M. Krieg +11 more
TL;DR: RTMS is a more sensitive but less specific tool for preoperative language mapping than DCS and leads to a higher correlation to DCS than both techniques alone, and the presented protocols for combined noninvasive language mapping might play a supportive role in the language-mapping assessment prior to the gold-standard intraoperative DCS.
References
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The 2007 WHO Classification of Tumours of the Central Nervous System
David N. Louis,Hiroko Ohgaki,Otmar D. Wiestler,Webster K. Cavenee,Peter C. Burger,Anne Jouvet,Bernd W. Scheithauer,Paul Kleihues +7 more
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Journal ArticleDOI
Role of Extent of Resection in the Long-Term Outcome of Low-Grade Hemispheric Gliomas
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Journal ArticleDOI
Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial.
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Journal ArticleDOI
Prognostic Factors for Survival in Adult Patients With Cerebral Low-Grade Glioma
Francesco Pignatti,Martin J. van den Bent,Desmond Curran,C. Debruyne,Richard Sylvester,Patrick Therasse,D Afra,Philippe Cornu,Michel Bolla,Charles J. Vecht,A.B.M.F. Karim +10 more
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