Journal ArticleDOI
Spontaneous and therapeutic prognostic factors in adult hemispheric World Health Organization Grade II gliomas: a series of 1097 cases: clinical article.
Laurent Capelle,Denys Fontaine,Emmanuel Mandonnet,Luc Taillandier,Jean Louis Golmard,Luc Bauchet,Johan Pallud,Philippe Peruzzi,Marie Hélène Baron,Michèle Kujas,Jacques Guyotat,Remi Guillevin,Marc Frenay,Sophie Taillibert,Philippe Colin,Valérie Rigau,F. Vandenbos,Catherine Pinelli,Hugues Duffau,French Réseau d'Étude des Gliomes +19 more
TLDR
This large series with its volumetric assessment refines the prognostic value of previously stressed clinical and radiological parameters and highlights the importance of tumor size and location.Abstract:
Object The spontaneous prognostic factors and optimal therapeutic strategy for WHO Grade II gliomas (GIIGs) have yet to be unanimously defined. Specifically, the role of resection is still debated, most notably because the actual amount of resection has seldom been assessed. Methods Cases of GIIGs treated before December 2007 were extracted from a multicenter database retrospectively collected since January 1985 and prospectively collected since 1996. Inclusion criteria were a patient age ≥ 18 years at diagnosis, histological diagnosis of WHO GIIG, and MRI evaluation of tumor volume at diagnosis and after initial surgery. One thousand ninety-seven lesions were included in the analysis. The mean follow-up was 7.4 years since radiological diagnosis. Factors significant in a univariate analysis (with a p value ≤ 0.1) were included in the multivariate Cox proportional hazard regression model analysis. Results At the time of radiological diagnosis, independent spontaneous factors of a poor prognosis were an ag...read more
Citations
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Initial Experience Using Awake Surgery for Glioma: Oncological, Functional, and Employment Outcomes in a Consecutive Series of 25 Cases
Emmanuel Mandonnet,Philip C. De Witt Hamer,Isabelle Poisson,Ian R. Whittle,Anne-Laure Bernat,Damien Bresson,Caterina Madadaki,Schahrazed Bouazza,Renata Ursu,Antoine F. Carpentier,Bernard George,Sébastien Froelich +11 more
TL;DR: These oncological and functional results of awake glioma surgery during the learning curve are comparable to results from established centers and the use and utility of resection probability maps are well demonstrated.
Journal ArticleDOI
Lesion location implemented magnetic resonance imaging radiomics for predicting IDH and TERT promoter mutations in grade II/III gliomas.
Hideyuki Arita,Manabu Kinoshita,Atsushi Kawaguchi,Masamichi Takahashi,Yoshitaka Narita,Yuzo Terakawa,Naohiro Tsuyuguchi,Naohiro Tsuyuguchi,Yoshiko Okita,Masahiro Nonaka,Shusuke Moriuchi,Masatoshi Takagaki,Yasunori Fujimoto,Junya Fukai,Shuichi Izumoto,Kenichi Ishibashi,Yoshikazu Nakajima,Tomoko Shofuda,Daisuke Kanematsu,Ema Yoshioka,Yoshinori Kodama,Masayuki Mano,Kanji Mori,Koichi Ichimura,Yonehiro Kanemura +24 more
TL;DR: Conventional MRI-based radiomics is one of the most promising strategies that may lead to a non-invasive diagnostic technique for molecular characterization of grade II/III gliomas.
Journal ArticleDOI
A new philosophy in surgery for diffuse low-grade glioma (DLGG): oncological and functional outcomes.
TL;DR: Recent data strongly argue in favor of achieving a maximal resection of DLGG as the first therapeutic option, according to functional (and not purely oncological or anatomical) boundaries in awake patients.
Journal ArticleDOI
Patients with incidental WHO grade II glioma frequently suffer from neuropsychological disturbances
TL;DR: It is suggested that numerous iLGG patients have neuropsychological impairments, for the first time to the authors' knowledge, because of the high prevalence of insidious cognitive deficits.
Journal ArticleDOI
Management of low-grade glioma: a systematic review and meta-analysis.
Timothy J. Brown,Daniela A. Bota,Martin J. van den Bent,Paul D. Brown,Elizabeth A. Maher,Dawit Aregawi,Linda M. Liau,Jan C. Buckner,Michael Weller,Mitchel S. Berger,Michael Glantz +10 more
TL;DR: This evidence-based meta-analysis evaluates the association of extent of resection, radiation, and chemotherapy with mortality and progression-free survival at 2, 5, and 10 years in patients with low-grade glioma, and is the first to quantify differences in outcome associated with surgery, radiation and chemotherapy.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
Prognostic Factors for Survival in Adult Patients With Cerebral Low-Grade Glioma
Francesco Pignatti,Martin J. van den Bent,Desmond Curran,C. Debruyne,Richard Sylvester,Patrick Therasse,D Afra,Philippe Cornu,Michel Bolla,Charles J. Vecht,A.B.M.F. Karim +10 more
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