Journal ArticleDOI
Spontaneous and therapeutic prognostic factors in adult hemispheric World Health Organization Grade II gliomas: a series of 1097 cases: clinical article.
Laurent Capelle,Denys Fontaine,Emmanuel Mandonnet,Luc Taillandier,Jean Louis Golmard,Luc Bauchet,Johan Pallud,Philippe Peruzzi,Marie Hélène Baron,Michèle Kujas,Jacques Guyotat,Remi Guillevin,Marc Frenay,Sophie Taillibert,Philippe Colin,Valérie Rigau,F. Vandenbos,Catherine Pinelli,Hugues Duffau,French Réseau d'Étude des Gliomes +19 more
TLDR
This large series with its volumetric assessment refines the prognostic value of previously stressed clinical and radiological parameters and highlights the importance of tumor size and location.Abstract:
Object The spontaneous prognostic factors and optimal therapeutic strategy for WHO Grade II gliomas (GIIGs) have yet to be unanimously defined. Specifically, the role of resection is still debated, most notably because the actual amount of resection has seldom been assessed. Methods Cases of GIIGs treated before December 2007 were extracted from a multicenter database retrospectively collected since January 1985 and prospectively collected since 1996. Inclusion criteria were a patient age ≥ 18 years at diagnosis, histological diagnosis of WHO GIIG, and MRI evaluation of tumor volume at diagnosis and after initial surgery. One thousand ninety-seven lesions were included in the analysis. The mean follow-up was 7.4 years since radiological diagnosis. Factors significant in a univariate analysis (with a p value ≤ 0.1) were included in the multivariate Cox proportional hazard regression model analysis. Results At the time of radiological diagnosis, independent spontaneous factors of a poor prognosis were an ag...read more
Citations
More filters
Journal ArticleDOI
Acute progression of untreated incidental WHO Grade II glioma to glioblastoma in an asymptomatic patient
TL;DR: The case of a 43-year-old woman with a right operculo-insular LGG that was incidentally diagnosed because of headaches demonstrates that acute transformation to glioblastoma may nonetheless occur, even before the onset of any symptoms.
Journal ArticleDOI
Surgical resection of incidental diffuse gliomas involving eloquent brain areas. Rationale, functional, epileptological and oncological outcomes.
Guilherme Lucas de Oliveira Lima,Edouard Dezamis,Robert Corns,O. Rigaux-Viode,Sylvie Moritz-Gasser,Alexandre Roux,Hugues Duffau,Johan Pallud +7 more
TL;DR: The reproducibility, safety, and effectiveness of an early maximal functionally based resection within cortico-subcortical functional boundaries for incidental diffuse low-grade gliomas in adults in centres hyperspecialized in surgical neuro-oncology are suggested.
Journal ArticleDOI
The Diagnostic Properties of Intraoperative Ultrasound in Glioma Surgery and Factors Associated with Gross Total Tumor Resection
Bodil Karoline Ravn Munkvold,Asgeir Store Jakola,Ingerid Reinertsen,Lisa Millgård Sagberg,Geirmund Unsgård,Ole Solheim +5 more
TL;DR: The specificity of intraoperative US is good, but sensitivity for detecting the last milliliter is low compared with postoperative MRI, and tumor volume and tumor depth are the predictors of achieving gross total resection, although ultrasound image quality was not.
Journal ArticleDOI
Extent of resection and survival in supratentorial infiltrative low-grade gliomas: analysis of and adjustment for treatment bias
TL;DR: Treatment bias was not responsible for the correlation between extent of resection and survival observed in the present series, and data seem to provide further support for a strategy of maximum safe resections for low-grade gliomas.
Journal ArticleDOI
Linking late cognitive outcome with glioma surgery location using resection cavity maps.
Eef J. Hendriks,Esther J. J. Habets,Martin J B Taphoorn,Linda Douw,Aeilko H. Zwinderman,W. Peter Vandertop,Frederik Barkhof,Martin Klein,Philip C. De Witt Hamer +8 more
TL;DR: Cognitive decline after resective surgery of diffuse glioma is prevalent, in particular, in patients with a tumor located in the right hemisphere without cognitive function mapping, including the frontal pole and the corpus callosum.
References
More filters
Journal ArticleDOI
The 2007 WHO Classification of Tumours of the Central Nervous System
David N. Louis,Hiroko Ohgaki,Otmar D. Wiestler,Webster K. Cavenee,Peter C. Burger,Anne Jouvet,Bernd W. Scheithauer,Paul Kleihues +7 more
TL;DR: The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneurs tumour of the fourth ventricle, Papillary tumourof the pineal region, pituicytoma and spindle cell oncocytoma of the adenohypophysis.
Journal ArticleDOI
Glioma extent of resection and its impact on patient outcome.
Nader Sanai,Mitchel S. Berger +1 more
TL;DR: Despite persistent limitations in the quality of data, mounting evidence suggests that more extensive surgical resection is associated with longer life expectancy for both low- and high-grade gliomas.
Journal ArticleDOI
Role of Extent of Resection in the Long-Term Outcome of Low-Grade Hemispheric Gliomas
Justin S. Smith,Edward F. Chang,Kathleen R. Lamborn,Susan M. Chang,Michael D. Prados,Soonmee Cha,Tarik Tihan,Scott R. VandenBerg,Michael W. McDermott,Mitchel S. Berger +9 more
TL;DR: Improved outcome among adult patients with hemispheric LGG is predicted by greater EOR, and progression-free survival was predicted by log preoperative tumor volume and postoperative volume.
Journal ArticleDOI
Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial.
M. J. van den Bent,D Afra,O De Witte,M Ben Hassel,S. Schraub,Khê Hoang-Xuan,Per-Uno Malmström,Laurence Collette,Marianne Pierart,René-Olivier Mirimanoff,Abmf Karim +10 more
TL;DR: Early radiotherapy after surgery lengthens the period without progression but does not affect overall survival, and Radiotherapy could be deferred for patients with low-grade glioma who are in a good condition, provided they are carefully monitored.
Journal ArticleDOI
Prognostic Factors for Survival in Adult Patients With Cerebral Low-Grade Glioma
Francesco Pignatti,Martin J. van den Bent,Desmond Curran,C. Debruyne,Richard Sylvester,Patrick Therasse,D Afra,Philippe Cornu,Michel Bolla,Charles J. Vecht,A.B.M.F. Karim +10 more
TL;DR: In adult patients with LGG, older age, astrocytoma histology, presence of neurologic deficits before surgery, largest tumor diameter, and tumor crossing the midline were important prognostic factors for survival and can be used to identify low-risk and high-risk patients.