Journal ArticleDOI
Spontaneous and therapeutic prognostic factors in adult hemispheric World Health Organization Grade II gliomas: a series of 1097 cases: clinical article.
Laurent Capelle,Denys Fontaine,Emmanuel Mandonnet,Luc Taillandier,Jean Louis Golmard,Luc Bauchet,Johan Pallud,Philippe Peruzzi,Marie Hélène Baron,Michèle Kujas,Jacques Guyotat,Remi Guillevin,Marc Frenay,Sophie Taillibert,Philippe Colin,Valérie Rigau,F. Vandenbos,Catherine Pinelli,Hugues Duffau,French Réseau d'Étude des Gliomes +19 more
TLDR
This large series with its volumetric assessment refines the prognostic value of previously stressed clinical and radiological parameters and highlights the importance of tumor size and location.Abstract:
Object The spontaneous prognostic factors and optimal therapeutic strategy for WHO Grade II gliomas (GIIGs) have yet to be unanimously defined. Specifically, the role of resection is still debated, most notably because the actual amount of resection has seldom been assessed. Methods Cases of GIIGs treated before December 2007 were extracted from a multicenter database retrospectively collected since January 1985 and prospectively collected since 1996. Inclusion criteria were a patient age ≥ 18 years at diagnosis, histological diagnosis of WHO GIIG, and MRI evaluation of tumor volume at diagnosis and after initial surgery. One thousand ninety-seven lesions were included in the analysis. The mean follow-up was 7.4 years since radiological diagnosis. Factors significant in a univariate analysis (with a p value ≤ 0.1) were included in the multivariate Cox proportional hazard regression model analysis. Results At the time of radiological diagnosis, independent spontaneous factors of a poor prognosis were an ag...read more
Citations
More filters
Journal ArticleDOI
Motor Cortex Reorganization in Patients with Glioma Assessed by Repeated Navigated Transcranial Magnetic Stimulation-A Longitudinal Study.
TL;DR: Despite the low potential of remodeling within the somatosensory region, long-term reorganization of cortical motor function can be observed and nTMS is best suited for a noninvasive evaluation of this reorganization.
Journal ArticleDOI
Anesthesia management for low-grade glioma awake surgery: a European Low-Grade Glioma Network survey.
Jeremy Arzoine,Charlotte Levé,Antonio Pérez-Hick,John Goodden,Fabien Almairac,Sylvie Aubrun,Etienne Gayat,Christian F. Freyschlag,Fabrice Vallée,Emmanuel Mandonnet,Catherine Madadaki +10 more
TL;DR: There was an equivalent proportion of centers using SAS or MAC protocols in the anesthetic management of awake surgery in ELGGN centers, and pain management was mostly based on paracetamol and remifentanil.
Journal ArticleDOI
Return to work following diagnosis of low-grade glioma: A nationwide matched cohort study.
Isabelle Rydén,Isabelle Rydén,Louise Carstam,Louise Carstam,Sasha Gulati,Anja Smits,Anja Smits,Anja Smits,Katharina S. Sunnerhagen,Per Hellström,Per Hellström,Roger Henriksson,Jiri Bartek,Jiri Bartek,Jiri Bartek,Øyvind Salvesen,Asgeir Store Jakola,Asgeir Store Jakola +17 more
TL;DR: Lower functional status, previous sick leave, older age, and adjuvant treatment were risk factors for no return-to-work at 1 year after surgery, and female sex, comorbidity, and biopsy only were also unfavorable for RTW at 2 years.
Journal ArticleDOI
Can Non-invasive Brain Stimulation Be Considered to Facilitate Reoperation for Low-Grade Glioma Relapse by Eliciting Neuroplasticity?
Hugues Duffau,Hugues Duffau +1 more
TL;DR: In this article, an early and maximal safe surgical resection, performed until critical neural networks have been identified by means of intraoperative corticosubcortical direct electrostimulation (DES) mapping in awake patients, is proposed.
Journal ArticleDOI
Preoperative Quantitative MR Tractography Compared with Visual Tract Evaluation in Patients with Neuropathologically Confirmed Gliomas Grades II and III: A Prospective Cohort Study
Anna Falk Delgado,Markus Nilsson,Francesco Latini,Johanna Mårtensson,Maria Zetterling,Shala Ghaderi Berntsson,Irina Alafuzoff,Jimmy Lätt,Elna-Marie Larsson +8 more
TL;DR: Tract segment infiltration on visual evaluation was associated with a lower rFA and high rMD in a majority of evaluated tract segments and Grade II and grade III gliomas had similar infiltrating behavior.
References
More filters
Journal ArticleDOI
The 2007 WHO Classification of Tumours of the Central Nervous System
David N. Louis,Hiroko Ohgaki,Otmar D. Wiestler,Webster K. Cavenee,Peter C. Burger,Anne Jouvet,Bernd W. Scheithauer,Paul Kleihues +7 more
TL;DR: The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneurs tumour of the fourth ventricle, Papillary tumourof the pineal region, pituicytoma and spindle cell oncocytoma of the adenohypophysis.
Journal ArticleDOI
Glioma extent of resection and its impact on patient outcome.
Nader Sanai,Mitchel S. Berger +1 more
TL;DR: Despite persistent limitations in the quality of data, mounting evidence suggests that more extensive surgical resection is associated with longer life expectancy for both low- and high-grade gliomas.
Journal ArticleDOI
Role of Extent of Resection in the Long-Term Outcome of Low-Grade Hemispheric Gliomas
Justin S. Smith,Edward F. Chang,Kathleen R. Lamborn,Susan M. Chang,Michael D. Prados,Soonmee Cha,Tarik Tihan,Scott R. VandenBerg,Michael W. McDermott,Mitchel S. Berger +9 more
TL;DR: Improved outcome among adult patients with hemispheric LGG is predicted by greater EOR, and progression-free survival was predicted by log preoperative tumor volume and postoperative volume.
Journal ArticleDOI
Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial.
M. J. van den Bent,D Afra,O De Witte,M Ben Hassel,S. Schraub,Khê Hoang-Xuan,Per-Uno Malmström,Laurence Collette,Marianne Pierart,René-Olivier Mirimanoff,Abmf Karim +10 more
TL;DR: Early radiotherapy after surgery lengthens the period without progression but does not affect overall survival, and Radiotherapy could be deferred for patients with low-grade glioma who are in a good condition, provided they are carefully monitored.
Journal ArticleDOI
Prognostic Factors for Survival in Adult Patients With Cerebral Low-Grade Glioma
Francesco Pignatti,Martin J. van den Bent,Desmond Curran,C. Debruyne,Richard Sylvester,Patrick Therasse,D Afra,Philippe Cornu,Michel Bolla,Charles J. Vecht,A.B.M.F. Karim +10 more
TL;DR: In adult patients with LGG, older age, astrocytoma histology, presence of neurologic deficits before surgery, largest tumor diameter, and tumor crossing the midline were important prognostic factors for survival and can be used to identify low-risk and high-risk patients.