Journal ArticleDOI
Spontaneous and therapeutic prognostic factors in adult hemispheric World Health Organization Grade II gliomas: a series of 1097 cases: clinical article.
Laurent Capelle,Denys Fontaine,Emmanuel Mandonnet,Luc Taillandier,Jean Louis Golmard,Luc Bauchet,Johan Pallud,Philippe Peruzzi,Marie Hélène Baron,Michèle Kujas,Jacques Guyotat,Remi Guillevin,Marc Frenay,Sophie Taillibert,Philippe Colin,Valérie Rigau,F. Vandenbos,Catherine Pinelli,Hugues Duffau,French Réseau d'Étude des Gliomes +19 more
TLDR
This large series with its volumetric assessment refines the prognostic value of previously stressed clinical and radiological parameters and highlights the importance of tumor size and location.Abstract:
Object The spontaneous prognostic factors and optimal therapeutic strategy for WHO Grade II gliomas (GIIGs) have yet to be unanimously defined. Specifically, the role of resection is still debated, most notably because the actual amount of resection has seldom been assessed. Methods Cases of GIIGs treated before December 2007 were extracted from a multicenter database retrospectively collected since January 1985 and prospectively collected since 1996. Inclusion criteria were a patient age ≥ 18 years at diagnosis, histological diagnosis of WHO GIIG, and MRI evaluation of tumor volume at diagnosis and after initial surgery. One thousand ninety-seven lesions were included in the analysis. The mean follow-up was 7.4 years since radiological diagnosis. Factors significant in a univariate analysis (with a p value ≤ 0.1) were included in the multivariate Cox proportional hazard regression model analysis. Results At the time of radiological diagnosis, independent spontaneous factors of a poor prognosis were an ag...read more
Citations
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Journal ArticleDOI
5-ALA in Suspected Low-Grade Gliomas: Current Role, Limitations, and New Approaches.
Barbara Kiesel,Julia Freund,David Reichert,Lisa I. Wadiura,Mikael T. Erkkilae,Adelheid Woehrer,Shawn L. Hervey-Jumper,Mitchel S. Berger,Georg Widhalm +8 more
TL;DR: In this article, the authors discuss the current role of 5-aminolevulinic acid (5-ALA) for intraoperative visualization of focal malignant transformation within suspected low-grade gliomas (LGG).
Journal ArticleDOI
Preoperative Navigated Transcranial Magnetic Stimulation Improves Gross Total Resection Rates in Patients with Motor-Eloquent High-Grade Gliomas: A Matched Cohort Study.
Philipp Hendrix,Yvonne Dzierma,Benedikt W. Burkhardt,Andreas Simgen,Gudrun Wagenpfeil,Christoph J. Griessenauer,Sebastian Senger,Joachim Oertel +7 more
TL;DR: Preoperative nTMS improves GTR rates without jeopardizing neurological function in patients who underwent surgery for a motor-eloquent supratentorial glioma or metastasis guided by preoperative n TMS, and in the setting of a potential survival benefit remains to be determined.
Journal ArticleDOI
Resection of supratentorial gliomas: the need to merge microsurgical technical cornerstones with modern functional mapping concepts. An overview
TL;DR: The reader should become more familiar with a comprehensive panel of techniques and methodologies but more importantly become aware that these recent technical advances facilitate a conceptual change from classical surgical paradigms toward a more patient-specific approach.
Journal ArticleDOI
Postoperative follow-up for selected diffuse low-grade gliomas with WHO grade III/IV foci
TL;DR: Postponing the medical treatment in DLGG with foci of malignant tumor following total or subtotal resection should be considered in selected patients.
Book ChapterDOI
Surgery for Gliomas
TL;DR: In this chapter, the functional anatomy of the human brain relevant to intrinsic tumor resection is reviewed and general principles governing surgical management of patients are highlighted, with a particular emphasis on awake brain mapping.
References
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Journal ArticleDOI
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Journal ArticleDOI
Prognostic Factors for Survival in Adult Patients With Cerebral Low-Grade Glioma
Francesco Pignatti,Martin J. van den Bent,Desmond Curran,C. Debruyne,Richard Sylvester,Patrick Therasse,D Afra,Philippe Cornu,Michel Bolla,Charles J. Vecht,A.B.M.F. Karim +10 more
TL;DR: In adult patients with LGG, older age, astrocytoma histology, presence of neurologic deficits before surgery, largest tumor diameter, and tumor crossing the midline were important prognostic factors for survival and can be used to identify low-risk and high-risk patients.