Journal ArticleDOI
Spontaneous and therapeutic prognostic factors in adult hemispheric World Health Organization Grade II gliomas: a series of 1097 cases: clinical article.
Laurent Capelle,Denys Fontaine,Emmanuel Mandonnet,Luc Taillandier,Jean Louis Golmard,Luc Bauchet,Johan Pallud,Philippe Peruzzi,Marie Hélène Baron,Michèle Kujas,Jacques Guyotat,Remi Guillevin,Marc Frenay,Sophie Taillibert,Philippe Colin,Valérie Rigau,F. Vandenbos,Catherine Pinelli,Hugues Duffau,French Réseau d'Étude des Gliomes +19 more
TLDR
This large series with its volumetric assessment refines the prognostic value of previously stressed clinical and radiological parameters and highlights the importance of tumor size and location.Abstract:
Object The spontaneous prognostic factors and optimal therapeutic strategy for WHO Grade II gliomas (GIIGs) have yet to be unanimously defined. Specifically, the role of resection is still debated, most notably because the actual amount of resection has seldom been assessed. Methods Cases of GIIGs treated before December 2007 were extracted from a multicenter database retrospectively collected since January 1985 and prospectively collected since 1996. Inclusion criteria were a patient age ≥ 18 years at diagnosis, histological diagnosis of WHO GIIG, and MRI evaluation of tumor volume at diagnosis and after initial surgery. One thousand ninety-seven lesions were included in the analysis. The mean follow-up was 7.4 years since radiological diagnosis. Factors significant in a univariate analysis (with a p value ≤ 0.1) were included in the multivariate Cox proportional hazard regression model analysis. Results At the time of radiological diagnosis, independent spontaneous factors of a poor prognosis were an ag...read more
Citations
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Journal ArticleDOI
The huge plastic potential of adult brain and the role of connectomics: new insights provided by serial mappings in glioma surgery.
TL;DR: A better understanding of cerebral connectomics leads to the conclusion that the white matter connectivity constitutes a main limitation of such brain plasticity, explaining the lack of recovery in patients with extensive subcortical damages.
Journal ArticleDOI
New concepts in the management of diffuse low-grade glioma: Proposal of a multistage and individualized therapeutic approach.
Hugues Duffau,Luc Taillandier +1 more
TL;DR: The aim is to switch towards a more holistic concept based upon the anticipation of a personalized and long-term multistage therapeutic approach, with online adaptation of the strategy over the years using feedback from clinical, radiological, and histomolecular monitoring.
Journal ArticleDOI
Surgical resection versus watchful waiting in low-grade gliomas.
Asgeir Store Jakola,Asgeir Store Jakola,Anne Jarstein Skjulsvik,Kristin Smistad Myrmel,Kristin Sjåvik,Geirmund Unsgård,Sverre H. Torp,Kristin Aaberg,Thomas Berg,Hong Yan Dai,K. Johnsen,Roar Kloster,Ole Solheim +12 more
TL;DR: In parallel population-based cohorts of LGGs, early surgical resection resulted in a clinical relevant survival benefit and the effect on survival persisted after adjustment for molecular markers.
Journal ArticleDOI
Surgical oncology for gliomas: the state of the art.
Nader Sanai,Mitchel S. Berger +1 more
TL;DR: The state of the art in surgical oncology for gliomas is outlined and approaches to minimizing the risk of perioperative morbidity continue to be improved through the combined use of stimulation-mapping techniques, corticospinal tract imaging, and stereotactic thermal ablation.
Journal ArticleDOI
The impact of surgery in molecularly defined low-grade glioma: an integrated clinical, radiological, and molecular analysis.
Maarten M. J. Wijnenga,Pim J. French,Hendrikus J. Dubbink,Winand N.M. Dinjens,Peggy N. Atmodimedjo,Johan M. Kros,Marion Smits,Renske Gahrmann,Geert-Jan Rutten,Jeroen B Verheul,Ruth Fleischeuer,Clemens M F Dirven,Arnaud J P E Vincent,Martin J. van den Bent +13 more
TL;DR: The data provide the necessary reevaluation of the impact of surgery in molecularly defined LGG and support maximal resection as first-line treatment for molecularlydefined LGG subtypes.
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