Journal ArticleDOI
Spontaneous and therapeutic prognostic factors in adult hemispheric World Health Organization Grade II gliomas: a series of 1097 cases: clinical article.
Laurent Capelle,Denys Fontaine,Emmanuel Mandonnet,Luc Taillandier,Jean Louis Golmard,Luc Bauchet,Johan Pallud,Philippe Peruzzi,Marie Hélène Baron,Michèle Kujas,Jacques Guyotat,Remi Guillevin,Marc Frenay,Sophie Taillibert,Philippe Colin,Valérie Rigau,F. Vandenbos,Catherine Pinelli,Hugues Duffau,French Réseau d'Étude des Gliomes +19 more
TLDR
This large series with its volumetric assessment refines the prognostic value of previously stressed clinical and radiological parameters and highlights the importance of tumor size and location.Abstract:
Object The spontaneous prognostic factors and optimal therapeutic strategy for WHO Grade II gliomas (GIIGs) have yet to be unanimously defined. Specifically, the role of resection is still debated, most notably because the actual amount of resection has seldom been assessed. Methods Cases of GIIGs treated before December 2007 were extracted from a multicenter database retrospectively collected since January 1985 and prospectively collected since 1996. Inclusion criteria were a patient age ≥ 18 years at diagnosis, histological diagnosis of WHO GIIG, and MRI evaluation of tumor volume at diagnosis and after initial surgery. One thousand ninety-seven lesions were included in the analysis. The mean follow-up was 7.4 years since radiological diagnosis. Factors significant in a univariate analysis (with a p value ≤ 0.1) were included in the multivariate Cox proportional hazard regression model analysis. Results At the time of radiological diagnosis, independent spontaneous factors of a poor prognosis were an ag...read more
Citations
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Journal ArticleDOI
Network Plasticity and Intraoperative Mapping for Personalized Multimodal Management of Diffuse Low-Grade Gliomas
TL;DR: The concept of neuro-oncology as a brain network surgery has major implications in terms of the clinical management and ensuing outcomes, as indexed by the increased survival and quality of life of patients managed using such an approach.
Journal ArticleDOI
Targeted Radiolabeled Compounds in Glioma Therapy.
TL;DR: The consistent overexpression of neurokinin type 1 receptors in gliomas WHO grades II-IV has been used to develop a therapeutic substance P-based targeting system and the results compare favorably with standard therapy.
Journal ArticleDOI
Surgical management of lower-grade glioma in the spotlight of the 2016 WHO classification system
Daniel Delev,Dieter Henrik Heiland,Pamela Franco,Peter C. Reinacher,Irina Mader,Ori Staszewski,Ori Staszewski,Silke Lassmann,Stefan Grau,Oliver Schnell +9 more
TL;DR: The impact of surgical treatment on the outcome of lower-grade gliomas depends to a great extent on the molecular subtype of the tumors, and patients with more aggressive tumors (IDH-wildtype) seem to profit from more intensive treatment like GTR, multiple resections and combined radio-/chemotherapy.
Journal ArticleDOI
Diffuse low-grade glioma - Changing concepts in diagnosis and management: A review
TL;DR: A review of the recent advances in the molecular diagnosis and management of diffuse low-grade gliomas with trends toward multidisciplinary and multimodality management of dLGG with an aim to surgically resect the primary disease followed by chemoradiation in cases of progressive or recurrent disease.
Journal ArticleDOI
Does early resection of presumed low-grade glioma improve survival? A clinical perspective
Maarten M. J. Wijnenga,Tariq Mattni,Pim J. French,Geert-Jan Rutten,Sieger Leenstra,Fred Kloet,Martin J B Taphoorn,Martin J. van den Bent,Clemens M F Dirven,Marie-Lise C. van Veelen,Arnaud J P E Vincent +10 more
TL;DR: In this cohort, it is failed to confirm superiority of early resection over a wait-and-scan approach in terms of overall survival, though longer follow-up is required for final conclusion.
References
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Journal ArticleDOI
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Journal ArticleDOI
Prognostic Factors for Survival in Adult Patients With Cerebral Low-Grade Glioma
Francesco Pignatti,Martin J. van den Bent,Desmond Curran,C. Debruyne,Richard Sylvester,Patrick Therasse,D Afra,Philippe Cornu,Michel Bolla,Charles J. Vecht,A.B.M.F. Karim +10 more
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