Journal ArticleDOI
Spontaneous and therapeutic prognostic factors in adult hemispheric World Health Organization Grade II gliomas: a series of 1097 cases: clinical article.
Laurent Capelle,Denys Fontaine,Emmanuel Mandonnet,Luc Taillandier,Jean Louis Golmard,Luc Bauchet,Johan Pallud,Philippe Peruzzi,Marie Hélène Baron,Michèle Kujas,Jacques Guyotat,Remi Guillevin,Marc Frenay,Sophie Taillibert,Philippe Colin,Valérie Rigau,F. Vandenbos,Catherine Pinelli,Hugues Duffau,French Réseau d'Étude des Gliomes +19 more
TLDR
This large series with its volumetric assessment refines the prognostic value of previously stressed clinical and radiological parameters and highlights the importance of tumor size and location.Abstract:
Object The spontaneous prognostic factors and optimal therapeutic strategy for WHO Grade II gliomas (GIIGs) have yet to be unanimously defined. Specifically, the role of resection is still debated, most notably because the actual amount of resection has seldom been assessed. Methods Cases of GIIGs treated before December 2007 were extracted from a multicenter database retrospectively collected since January 1985 and prospectively collected since 1996. Inclusion criteria were a patient age ≥ 18 years at diagnosis, histological diagnosis of WHO GIIG, and MRI evaluation of tumor volume at diagnosis and after initial surgery. One thousand ninety-seven lesions were included in the analysis. The mean follow-up was 7.4 years since radiological diagnosis. Factors significant in a univariate analysis (with a p value ≤ 0.1) were included in the multivariate Cox proportional hazard regression model analysis. Results At the time of radiological diagnosis, independent spontaneous factors of a poor prognosis were an ag...read more
Citations
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Journal ArticleDOI
Neuropsychological assessments before and after awake surgery for incidental low-grade gliomas.
Sam Ng,Guillaume Herbet,Guillaume Herbet,Anne-Laure Lemaitre,Jérôme Cochereau,Sylvie Moritz-Gasser,Sylvie Moritz-Gasser,Hugues Duffau,Hugues Duffau +8 more
TL;DR: Early surgical treatment in presumed asymptomatic patients with incidental low-grade glioma with ILGG was associated with stable or improved neuropsychological outcomes in 87.2% of patients at 3 months, with only mild cognitive decline observed in 6 patients.
Journal ArticleDOI
Preserving quality of life is not incompatible with increasing overall survival in diffuse low-grade glioma patients.
TL;DR: It is suggested that it could be acceptable to give patients with diffuse low-grade glioma (DLGG) the choice of more substantial surgical resection, leading to permanent neurological deficits, including with regard to motor and language functions.
Journal ArticleDOI
Low grade glioma: An Update for Radiologists
Jennifer Larsen,Steve B Wharton,Fiona M. McKevitt,Charles A.J. Romanowski,Caroline Bridgewater,Hesham Zaki,Nigel Hoggard +6 more
TL;DR: The earlier and more radical surgical resection of LGG and what it means for patients undergoing imaging is discussed.
Journal ArticleDOI
Proton therapy for low-grade gliomas in adults: A systematic review.
Erik Thurin,Erik Thurin,Petra Witt Nyström,Anja Smits,Katja Werlenius,Anna Bäck,Ann Liljegren,Eva-Lotte Daxberg,Asgeir Store Jakola +8 more
TL;DR: It is concluded that published data from clinical studies using proton therapy for adults with LGG are scarce and controlled clinical studies are urgently warranted to determine if the potential benefits based on comparative treatment planning translate into clinical benefits.
Journal ArticleDOI
Molecular features and clinical outcomes in surgically treated low-grade diffuse gliomas in patients over the age of 60.
Ramin A. Morshed,Seunggu J. Han,Shawn L. Hervey-Jumper,Melike Pekmezci,Irene Troncon,Susan M. Chang,Nicholas Butowski,Mitchel S. Berger +7 more
TL;DR: Older patients with diffuse gliomas may safely undergo aggressive treatment with surgical resection and adjuvant therapy and Elderly patients with low grade glioma have worse clinical outcomes compared to their younger counterparts.
References
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The 2007 WHO Classification of Tumours of the Central Nervous System
David N. Louis,Hiroko Ohgaki,Otmar D. Wiestler,Webster K. Cavenee,Peter C. Burger,Anne Jouvet,Bernd W. Scheithauer,Paul Kleihues +7 more
TL;DR: The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneurs tumour of the fourth ventricle, Papillary tumourof the pineal region, pituicytoma and spindle cell oncocytoma of the adenohypophysis.
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TL;DR: Despite persistent limitations in the quality of data, mounting evidence suggests that more extensive surgical resection is associated with longer life expectancy for both low- and high-grade gliomas.
Journal ArticleDOI
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Justin S. Smith,Edward F. Chang,Kathleen R. Lamborn,Susan M. Chang,Michael D. Prados,Soonmee Cha,Tarik Tihan,Scott R. VandenBerg,Michael W. McDermott,Mitchel S. Berger +9 more
TL;DR: Improved outcome among adult patients with hemispheric LGG is predicted by greater EOR, and progression-free survival was predicted by log preoperative tumor volume and postoperative volume.
Journal ArticleDOI
Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial.
M. J. van den Bent,D Afra,O De Witte,M Ben Hassel,S. Schraub,Khê Hoang-Xuan,Per-Uno Malmström,Laurence Collette,Marianne Pierart,René-Olivier Mirimanoff,Abmf Karim +10 more
TL;DR: Early radiotherapy after surgery lengthens the period without progression but does not affect overall survival, and Radiotherapy could be deferred for patients with low-grade glioma who are in a good condition, provided they are carefully monitored.
Journal ArticleDOI
Prognostic Factors for Survival in Adult Patients With Cerebral Low-Grade Glioma
Francesco Pignatti,Martin J. van den Bent,Desmond Curran,C. Debruyne,Richard Sylvester,Patrick Therasse,D Afra,Philippe Cornu,Michel Bolla,Charles J. Vecht,A.B.M.F. Karim +10 more
TL;DR: In adult patients with LGG, older age, astrocytoma histology, presence of neurologic deficits before surgery, largest tumor diameter, and tumor crossing the midline were important prognostic factors for survival and can be used to identify low-risk and high-risk patients.