Journal ArticleDOI
Spontaneous and therapeutic prognostic factors in adult hemispheric World Health Organization Grade II gliomas: a series of 1097 cases: clinical article.
Laurent Capelle,Denys Fontaine,Emmanuel Mandonnet,Luc Taillandier,Jean Louis Golmard,Luc Bauchet,Johan Pallud,Philippe Peruzzi,Marie Hélène Baron,Michèle Kujas,Jacques Guyotat,Remi Guillevin,Marc Frenay,Sophie Taillibert,Philippe Colin,Valérie Rigau,F. Vandenbos,Catherine Pinelli,Hugues Duffau,French Réseau d'Étude des Gliomes +19 more
TLDR
This large series with its volumetric assessment refines the prognostic value of previously stressed clinical and radiological parameters and highlights the importance of tumor size and location.Abstract:
Object The spontaneous prognostic factors and optimal therapeutic strategy for WHO Grade II gliomas (GIIGs) have yet to be unanimously defined. Specifically, the role of resection is still debated, most notably because the actual amount of resection has seldom been assessed. Methods Cases of GIIGs treated before December 2007 were extracted from a multicenter database retrospectively collected since January 1985 and prospectively collected since 1996. Inclusion criteria were a patient age ≥ 18 years at diagnosis, histological diagnosis of WHO GIIG, and MRI evaluation of tumor volume at diagnosis and after initial surgery. One thousand ninety-seven lesions were included in the analysis. The mean follow-up was 7.4 years since radiological diagnosis. Factors significant in a univariate analysis (with a p value ≤ 0.1) were included in the multivariate Cox proportional hazard regression model analysis. Results At the time of radiological diagnosis, independent spontaneous factors of a poor prognosis were an ag...read more
Citations
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Towards new tools for clinical evaluation and visualization of tumor growth in patients with glioma
TL;DR: A large number of patients diagnosed with glial cell-based primary brain tumors in adults have atypical prognosis, suggesting that the disease is more likely to be opportunistic than previously thought.
Journal ArticleDOI
Same but different. Incidental and symptomatic lower grade gliomas show differences in molecular features and survival
M. Demetz,Aleksandrs Krigers,Patrizia Moser,Johannes Kerschbaumer,Claudius Thomé,Christian F. Freyschlag +5 more
TL;DR: In this article , the authors investigated differences between patients with incidental (iLGG) and symptomatic lower grade Glioma (sLGG), and found that Incidental LGG showed significantly lower preoperative tumor volumes in T1 CE (p = 0.008), FLAIR (p < 0.038), DWI (p > 0.004), and lower expression of MIB-1 compared to sLGG.
Journal ArticleDOI
Awake Craniotomy for Left Insular Low-Grade Glioma Removal on a Patient with Learning Disabilities
TL;DR: Awake surgery for left insular LGG removal is challenging; however, it can be performed safely and successfully on PLD.
Book ChapterDOI
Awake Craniotomies for Neoplasms Involving Language Networks
Hugues Duffau,Hugues Duffau +1 more
TL;DR: A new concept based upon the investigation of the dynamics of individual language pathways in real time by means of intraoperative cognitive monitoring combined with electrical mapping in awake patients has resulted in a significant increase of surgical indications for lesions located within eloquent areas, with a decrease of permanent morbidity and an improvement of the oncological outcome.
Journal ArticleDOI
Adolescent and young adult glioma: systematic review of demographic, disease, and treatment influences on survival
Armaan K. Malhotra,Vishwathsen Karthikeyan,Veda Zabih,Alexander P. Landry,Julie Bennett,Ute Bartels,Paul C. Nathan,Uri Tabori,Cynthia Hawkins,Sunit Das,Sumit Gupta +10 more
TL;DR: Overall survival was highly variable across studies depending on glioma grade, anatomic compartment and cohort characteristics, and the prognostic influence of chemotherapy and radiotherapy on overall survival varied across studies with conflicting evidence.
References
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The 2007 WHO Classification of Tumours of the Central Nervous System
David N. Louis,Hiroko Ohgaki,Otmar D. Wiestler,Webster K. Cavenee,Peter C. Burger,Anne Jouvet,Bernd W. Scheithauer,Paul Kleihues +7 more
TL;DR: The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneurs tumour of the fourth ventricle, Papillary tumourof the pineal region, pituicytoma and spindle cell oncocytoma of the adenohypophysis.
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TL;DR: Despite persistent limitations in the quality of data, mounting evidence suggests that more extensive surgical resection is associated with longer life expectancy for both low- and high-grade gliomas.
Journal ArticleDOI
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TL;DR: Improved outcome among adult patients with hemispheric LGG is predicted by greater EOR, and progression-free survival was predicted by log preoperative tumor volume and postoperative volume.
Journal ArticleDOI
Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial.
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TL;DR: Early radiotherapy after surgery lengthens the period without progression but does not affect overall survival, and Radiotherapy could be deferred for patients with low-grade glioma who are in a good condition, provided they are carefully monitored.
Journal ArticleDOI
Prognostic Factors for Survival in Adult Patients With Cerebral Low-Grade Glioma
Francesco Pignatti,Martin J. van den Bent,Desmond Curran,C. Debruyne,Richard Sylvester,Patrick Therasse,D Afra,Philippe Cornu,Michel Bolla,Charles J. Vecht,A.B.M.F. Karim +10 more
TL;DR: In adult patients with LGG, older age, astrocytoma histology, presence of neurologic deficits before surgery, largest tumor diameter, and tumor crossing the midline were important prognostic factors for survival and can be used to identify low-risk and high-risk patients.