Journal ArticleDOI
Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes
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This article is published in Advanced Drug Delivery Reviews.The article was published on 1996-11-15. It has received 193 citations till now.read more
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Chitosan—A versatile semi-synthetic polymer in biomedical applications
TL;DR: The chemical structure and relevant biological properties of chitosan for regenerative medicine have been summarized as well as the methods for the preparation of controlled drug release devices and their applications.
Journal ArticleDOI
Chitosan and its derivatives for tissue engineering applications.
In Yong Kim,Seog Jin Seo,Hyun Seuk Moon,Mi Kyong Yoo,In Young Park,Bom Chol Kim,Chong-Su Cho +6 more
TL;DR: This review focuses on the various types of chitosan derivatives and their use in various tissue engineering applications namely, skin, bone, cartilage, liver, nerve and blood vessel.
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Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies
Nicola J. Hewitt,Maria Jose Gomez Lechon,J. Brian Houston,David Hallifax,Hayley S. Brown,Patrick Maurel,Patrick Maurel,J. Gerry Kenna,Lena Gustavsson,Christina Lohmann,Christian Skonberg,André Guillouzo,Gregor Tuschl,Albert P. Li,Edward L. LeCluyse,Geny M. M. Groothuis,Jan G. Hengstler +16 more
TL;DR: This review brings you up-to-date with the hepatocyte research on in vitro–in vivo correlations of metabolism and clearance, the function and regulation of hepatic transporters and models used to elucidate their role in drug clearance, mechanisms and examples of idiosyncratic and intrinsic hepatotoxicity.
Journal ArticleDOI
A microfabricated array bioreactor for perfused 3D liver culture
Mark J. Powers,Karel Domansky,M.R. Kaazempur-Mofrad,Artemis Kalezi,Adam Capitano,Arpita Upadhyaya,Petra Kurzawski,Kathryn E. Wack,Donna B. Stolz,Roger D. Kamm,Linda G. Griffith +10 more
TL;DR: It is observed that preaggregation of the cells into spheroidal structures prior to seeding improved the morphogenesis of tissue structure and maintenance of viability.
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Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.
TL;DR: Overall, primary cultures of human hepatocytes can serve as a sensitive and selective model for predicting the regulation of CYP450 modulation by drugs and other xenobiotics.
References
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The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
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Integrins: versatility, modulation, and signaling in cell adhesion.
Journal ArticleDOI
Integrins: a family of cell surface receptors.
TL;DR: This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.
Journal ArticleDOI
Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis
TL;DR: A coupling between physical adhesion and developmental signaling provides a mechanism to tightly integrate physical aspects of tissue morphogenesis with cell growth and differentiation, a coordination that is essential to achieve the intricate patterns of cells in tissues.
Book
Casarett and Doull's toxicology : the basic science of poisons
TL;DR: Casarett and Doull's Toxicology: The Basic Science of Poisons as mentioned in this paper is the most complete and up-to-date overview of the biomedical and environmental aspects of toxicology.