Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
Irina N. Krylova,Elena P. Sablin,Jamie Moore,Robert X. Xu,Gregory M. Waitt,J. Andrew MacKay,Dalia Juzumiene,Jane Bynum,Kevin P. Madauss,Valerie G. Montana,Lioudmila A. Lebedeva,Miyuki Suzawa,Jon D. Williams,Shawn P. Williams,Rodney K. Guy,Joseph W. Thornton,Robert J. Fletterick,Timothy M. Willson,Holly A. Ingraham +18 more
TLDR
Structural and biochemical data for three NR5A members-mouse and human SF-1 and human LRH-1-which reveal that these receptors bind phosphatidyl inositol second messengers and that ligand binding is required for maximal activity are presented.About:
This article is published in Cell.The article was published on 2005-02-11 and is currently open access. It has received 383 citations till now. The article focuses on the topics: Nuclear receptor & Receptor.read more
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Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
TL;DR: This review is an attempt to give an overview of this enormous research field focusing on major developments in diverse areas of basic science linked to cellular physiology and disease.
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Nuclear Receptors, RXR, and the Big Bang.
TL;DR: A personal perspective on nuclear receptors is provided and explores their integrated and coordinated signaling networks that are essential for multicellular life, highlighting the RXR heterodimer and its associated ligands and transcriptional mechanism.
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Overview of Nomenclature of Nuclear Receptors
TL;DR: The characterization of nuclear receptors and their associated proteins and the ligands that interact with them will remain a challenge to pharmacologists.
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Estrogen Signaling through the Transmembrane G Protein–Coupled Receptor GPR30
Eric R. Prossnitz,Jeffrey B. Arterburn,Jeffrey B. Arterburn,Harriet O. Smith,Tudor I. Oprea,Larry A. Sklar,Helen J. Hathaway +6 more
TL;DR: An overview of the evidence for the cellular and physiological actions of GPR30 in estrogen-dependent processes and the relationship of G PR30 with classical estrogen receptors is provided.
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Nuclear receptors — a perspective from drosophila
Kirst King-Jones,Carl S. Thummel +1 more
TL;DR: The fruit fly Drosophila melanogaster has only 18 nuclear-receptor genes, far fewer than any other genetic model organism and representing all 6 subfamilies of vertebrate receptors as discussed by the authors.
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