Journal ArticleDOI
The NF-κB signalling pathway in osteoarthritis
TLDR
The involvement of NF-κB in OA pathogenesis and how pharmacological inhibition of the NF-πB signalling pathway affects OA incidence and evolution are discussed.About:
This article is published in The International Journal of Biochemistry & Cell Biology.The article was published on 2013-11-01. It has received 357 citations till now.read more
Citations
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Journal ArticleDOI
ROS/oxidative stress signaling in osteoarthritis.
TL;DR: Targeting the complex oxidative stress signaling pathways would offer a valuable perspective for exploration of potential therapeutic strategies in the treatment of this devastating disease.
Journal ArticleDOI
Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use.
TL;DR: The goals of this review are to stimulate use of standardized nomenclature for OA that could serve as building blocks for describing OA and defining OA phenotypes to provide unifying disease concepts for a heterogeneous disorder.
Journal ArticleDOI
Role of Chondrocytes in Cartilage Formation, Progression of Osteoarthritis and Cartilage Regeneration.
Hemanth Akkiraju,Anja Nohe +1 more
TL;DR: The progress in cell based therapies that utilize Mesenchymal Stem Cell (MSC) infusion for cartilage repair may lead to new therapeutics in the long term, however, many questions are unanswered such as the efficacy of MSCs usage in therapy.
Journal ArticleDOI
NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction.
TL;DR: The roles of NF-κB in OA chondrocytes and related signaling pathways are discussed to better understand pathological cartilage remodeling and provide potential therapeutic targets that can interfere with NF-σB signaling for OA treatment.
Journal ArticleDOI
Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols
TL;DR: Plant polyphenols possess potent antioxidant and anti-inflammatory properties and can inhibit ROS production and inflammation in chondrocytes, cartilage explants and in animal models of OA.
References
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Journal ArticleDOI
The NF-κB Family of Transcription Factors and Its Regulation
Andrea Oeckinghaus,Sankar Ghosh +1 more
TL;DR: The NF-kappaB pathway is a paradigm for understanding general principles of signal transduction and gene regulation as well as other pathway-specific mediators, and the transcription factors are themselves extensively modified.
Journal ArticleDOI
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
TL;DR: The current knowledge regarding the role of proinflammatory cytokines in the pathophysiology of OA is discussed and the potential of anticytokine therapy in the treatment of this disease is addressed.
Journal ArticleDOI
The role of synovitis in osteoarthritis pathogenesis
TL;DR: Most studies have concluded that the presence of synovitis in OA is associated with more severe pain and joint dysfunction, and may be predictive of faster rates of cartilage loss in certain patient populations.
Journal ArticleDOI
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
Zuoning Han,David L. Boyle,Lufen Chang,Brydon L. Bennett,Michael Karin,Li Yang,Anthony M. Manning,Gary S. Firestein +7 more
TL;DR: The novel JNK inhibitor SP600125 completely blocked IL-1--induced accumulation of phospho-Jun and induction of c-Jun transcription in synoviocytes and in joint arthritis, indicating that JNK is an important therapeutic target for RA.
Journal ArticleDOI
Cartilage homeostasis in health and rheumatic diseases.
TL;DR: Understanding how the adult articular chondrocyte functions within its unique environment will aid in the development of rational strategies to protect cartilage from damage resulting from joint disease.