Book ChapterDOI
Surface Traffic in Synaptic Membranes
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TLDR
The observation of local protein surface dynamics starts to be a useful tool to determine the contribution of intracellular and extracellular structures in organizing a plastic synapse.Abstract:
The precision of signal transmission in chemical synapses is highly dependent on the structural alignment between pre- and postsynaptic components. The thermal agitation of transmembrane signaling molecules by surrounding lipid molecules and activity-driven changes in the local protein interaction affinities indicate a dynamic molecular traffic of molecules within synapses. The observation of local protein surface dynamics starts to be a useful tool to determine the contribution of intracellular and extracellular structures in organizing a plastic synapse. Local rearrangements by lateral diffusion in the synaptic and perisynaptic membrane induce fast density changes of signaling molecules and enable the synapse to change efficacy in short time scales. The degree of lateral mobility is restricted by many passive and active interactions inside and outside the membrane. AMPAR at the glutamatergic synapse are the best explored receptors in this respect and reviewed here as an example molecule. In addition, transsynaptic adhesion molecule complexes also appear highly dynamically in the synapse and do further support the importance of local surface traffic in subcellular compartments like synapses.read more
Citations
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Journal ArticleDOI
Regulators of synaptic transmission: Roles in the pathogenesis and treatment of epilepsy
TL;DR: The different mechanisms involved in the regulation of synaptic transmission, which may play a role in the pathogenesis of epilepsy: the presynaptic modulators of synaptic vesicle formation and release, postsynaptic receptors, and modulating the frequency and severity of epileptic seizures are focused on.
OtherDOI
Structure of the Synapse
John E. Heuser,Thomas S. Reese +1 more
TL;DR: The sections in this article are structure of the Presynaptic Active Zone, Vesicle Turnover and Transmitter Metabolism, and ultimate Origin and Fate of Synaptic Vesicles.
Journal ArticleDOI
De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures
Candace T. Myers,Nicholas Stong,Emily I. Mountier,Katherine L. Helbig,Saskia Freytag,Saskia Freytag,Joseph Sullivan,Bruria Ben Zeev,Andreea Nissenkorn,Michal Tzadok,Gali Heimer,Deepali N. Shinde,Arezoo Rezazadeh,Brigid M. Regan,Karen Oliver,Karen Oliver,Michelle E. Ernst,Natalie Lippa,Maureen S. Mulhern,Zhong Ren,Annapurna Poduri,Danielle M. Andrade,Lynne M. Bird,Lynne M. Bird,Melanie Bahlo,Melanie Bahlo,Samuel F. Berkovic,Daniel H. Lowenstein,Ingrid E. Scheffer,Ingrid E. Scheffer,Lynette G. Sadleir,David Goldstein,Heather C Mefford,Erin L. Heinzen +33 more
TL;DR: Six individuals with severe developmental delay, refractory seizures, and similar dysmorphic features, each harboring a de novo mutation in PPP3CA are identified and the emerging role for synaptic dysregulation in epilepsy is supported.
Journal ArticleDOI
Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.
Christian Neupert,Romy Schneider,Oliver Klatt,Carsten Reissner,Daniele Repetto,Barbara Biermann,Katharina Niesmann,Markus Missler,Martin Heine +8 more
TL;DR: In this paper, the authors performed single-particle tracking and live imaging of transfected, epitope-tagged Nrxn variants in cultured rat and mouse wild-type or knock-out neurons.
Journal ArticleDOI
Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors.
Nikhil J. Pandya,Christian Seeger,Norbert Babai,Miguel A. Gonzalez-Lozano,Volker Mack,Johannes C. Lodder,Yvonne Gouwenberg,Huibert D. Mansvelder,U. Helena Danielson,Ka Wan Li,Martin Heine,Sabine Spijker,Renato Frischknecht,Renato Frischknecht,August B. Smit +14 more
TL;DR: It is found that Noelin1 interacts with the AMPAR with high affinity, however, without affecting rise- and decay time and desensitization properties, the first evidence for the role of a secreted AMPAR-interacting protein on mobility of GluA1-containing receptors and synaptic plasticity.
References
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