Journal ArticleDOI
Synthesis and Physical Properties of Choline Carboxylate Ionic Liquids
Nawshad Muhammad,M. Ismail Hossain,Zakaria Man,Mohanad El-Harbawi,M. Azmi Bustam,Yousr Abdulhadi Noaman,Noorjahan Banu Alitheen,Mei Kee Ng,Glenn Hefter,Chun-Yang Yin +9 more
TLDR
A series of choline carboxylate ionic liquids (ILs) have been synthesized by neutralization of CHO2 solution with acetic, propanoic, butanoate, and hexanoate salts at temperatures from (293.15 to 353.15) K.Abstract:
A series of choline carboxylate ionic liquids (ILs) have been synthesized by neutralization of choline hydroxide solution with acetic, propanoic, butanoic, pivalic, and hexanoic acids. The salts so obtained were characterized by NMR spectroscopy, thermal methods, and elemental analysis. Key physical properties (density, viscosity, and refractive index) were measured for the propanoate, butanoate, and hexanoate salts at temperatures from (293.15 to 353.15) K. The densities were used to estimate the molecular volumes, standard entropies, crystal lattice energies, and thermal expansion coefficients. All five choline carboxylates were found to have cytotoxicities (IC50 values) above 10 mM toward the human breast cancer cell line, MCF-7, indicating they are much less toxic than common imidazolium-based ILs.read more
Citations
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Biocompatible ionic liquids: fundamental behaviours and applications
TL;DR: Progress and strategies towards the synthesis of Bio-ILs are reviewed and the impact of using these compounds in a diverse range of applications is discussed, with some insights toward their use in the development of improved technologies.
Journal ArticleDOI
In Vitro and In Vivo toxicity profiling of ammonium-based deep eutectic solvents.
TL;DR: This is the first time that combined In Vitro and In Vivo toxicity profiles of DESs were being demonstrated, raising the toxicity issue of these neoteric mixtures and their potential applicability to be used for therapeutic purposes.
Journal ArticleDOI
Ecotoxicity analysis of cholinium-based ionic liquids to Vibrio fischeri marine bacteria
Sónia P. M. Ventura,Francisca A. e Silva,Ana M. M. Gonçalves,Joana Luísa Pereira,Fernando Gonçalves,João A. P. Coutinho +5 more
TL;DR: The results suggest that the cholinium family exhibits a different mechanism of toxicity as compared to the imidazolium ionic liquids previously described in the literature.
Journal ArticleDOI
Synthesis and Thermophysical Properties of Biocompatible Cholinium-Based Amino Acid Ionic Liquids
TL;DR: In this paper, a series of cholinium-based AAILs were synthesized by neutralization of choline hydroxide solution with five amino acids and then were characterized by 1H NMR, Fourier transform infrared (FT-IR), elemental analysis, thermogravimetry, and differential scanning calorimetry (DSC) analysis.
Journal ArticleDOI
Choline based ionic liquids and their applications in organic transformation
TL;DR: The choline chloride (ChCl) based ionic liquids and deep eutectic solvents have emerged as an efficient replacement for imidazole-based ionic liquid and has opened up numerous opportunities owing to their non-toxic, biocompatible nature, easy accessibility and cost-effectiveness properties as discussed by the authors.
References
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Journal ArticleDOI
Characterization and comparison of hydrophilic and hydrophobic room temperature ionic liquids incorporating the imidazolium cation
Jonathan G. Huddleston,Ann E. Visser,W. Matthew Reichert,Heather D. Willauer,Grant A. Broker,Robin D. Rogers +5 more
TL;DR: A series of hydrophilic and hydrophobic 1-alkyl-3-methylimidazolium room temperature ionic liquids (RTILs) have been prepared and characterized to determine how water content, density, viscosity, surface tension, melting point, and thermal stability are affected by changes in alkyl chain length and anion.
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Ionic liquids. Green solvents for the future
TL;DR: In this paper, it has been shown that Ionic liquids, being composed entirely of ions, are green solvents, and that a wide range of chemical reactions can be performed in them.
Journal ArticleDOI
Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction
M.V. Berridge,A.S. Tan +1 more
TL;DR: Most cellular reduction of MTT occurs extramitochondrially and probably involves the pyridine nucleotide cofactors NADH and NADPH-dependent mechanisms that are insensitive to respiratory chain inhibitors.
Journal ArticleDOI
Density and viscosity of several pure and water-saturated ionic liquids
TL;DR: In this paper, the authors measured the viscosity and density of six ionic liquids (1-butyl-3-methylimidazolium hexafluorophosphate, 1-Butyl 3methylammonium bis(trifluoromethylsulfonyl)imide, butyltrimethylammmonium, ethyl sulfate and butyl trifluoric acid) with an accuracy of 10−3 g cm−3 and 1%, respectively.
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Choline: an essential nutrient for public health
TL;DR: Given the importance of choline in a wide range of critical functions in the human body, coupled with less-than-optimal intakes among the population, dietary guidance should be developed to encourage the intake of ch Caroline-rich foods.