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Open AccessJournal ArticleDOI

Systematic Review of Errors in Inhaler Use: Has Patient Technique Improved Over Time?

TLDR
In this paper, a systematic search for articles reporting direct observation of inhaler technique by trained personnel covered the period from 1975 to 2014, and the authors aimed to assess the most common errors in inhaler use over the past 40 years in patients treated with MDIs or dry powder inhalers (DPIs).
About
This article is published in Chest.The article was published on 2016-08-01 and is currently open access. It has received 370 citations till now. The article focuses on the topics: Metered-dose inhaler & Dry-powder inhaler.

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Citations
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Critical inhaler errors in asthma and COPD: a systematic review of impact on health outcomes

TL;DR: Wide variations in how critical errors are defined are shown, and the evidence shows an important association between inhaler errors and worsened health outcomes, and a need for a consensus on defining critical and non-critical errors.
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Device errors in asthma and COPD: systematic literature review and meta-analysis.

TL;DR: While Chrystyn’s team found high critical error rates reported across all devices, their meta-analysis and systematic review highlighted significant gaps in knowledge regarding different inhalers and associated error rates, and how these affect clinical outcomes.
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Drug delivery to the lungs: challenges and opportunities

TL;DR: Owing to the advantages offered by the pulmonary route, the challenges that the route poses are worth addressing, and if successfully addressed, the pulmonary routes offers huge opportunities, often fulfilling unmet clinical needs.
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Effectiveness and success factors of educational inhaler technique interventions in asthma & COPD patients: a systematic review

TL;DR: Educational interventions to improve inhaler technique are effective on the short-term but periodical intervention reinforcement and longer follow-up studies, including clinical relevant endpoints and cost-effectiveness, are recommended.
References
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Journal ArticleDOI

Measuring inconsistency in meta-analyses

TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Bias in meta-analysis detected by a simple, graphical test

TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Meta-Analysis in Clinical Trials*

TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
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The Strengthening the Reporting of Observational Studies in Epidemiology [STROBE] statement: guidelines for reporting observational studies

TL;DR: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) initiative developed recommendations on what should be included in an accurate and complete report of an observational study, resulting in a checklist of 22 items (the STROBE statement) that relate to the title, abstract, introduction, methods, results, and discussion sections of articles.
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