Targeting the Endocannabinoid System in the Treatment of Posttraumatic Stress Disorder: A Promising Case of Preclinical-Clinical Translation?
TLDR
The endocannabinoid (eCB) system is one of the most ubiquitous signaling systems of the brain and offers a rich pharmacology including multiple druggable targets as mentioned in this paper .About:
This article is published in Biological Psychiatry.The article was published on 2022-02-01 and is currently open access. It has received 23 citations till now. The article focuses on the topics: Endocannabinoid system & Fatty acid amide hydrolase.read more
Citations
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Neuropharmacological Modulation of N-methyl-D-aspartate, Noradrenaline and Endocannabinoid Receptors in Fear Extinction Learning: Synaptic Transmission and Plasticity
TL;DR: In this article , the role of specific neuropharmacological adjuvants that act on neurochemical synaptic transmission, as well as on brain plasticity processes implicated in fear memory was addressed.
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A Systematic Review and Meta-Analysis on the Effects of Exercise on the Endocannabinoid System
TL;DR: In this article , the authors performed a systematic review and the first meta-analysis to examine the impact of exercise on circulating endocannabinoid (eCB) concentrations in humans and animal models, which revealed a consistent increase in both anandamide and 2-arachidonoylglycerol (2-AG) following acute exercise across modalities.
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Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities.
TL;DR: In this paper , the authors comprehensively review N-acylethanolamines (NAEs) biosynthesis and degradation, their metabolism by lipoxygenases, cyclooxygenase and cytochrome P450s and the biological functions of these signaling lipids.
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The influence of FAAH genetic variation on physiological, cognitive, and neural signatures of fear acquisition and extinction learning in women with PTSD
TL;DR: In this article , the authors examined whether genetic variation in the FAAH gene (C385A; rs324420) influences physiological, cognitive, and neural indices of fear acquisition and extinction learning among a sample of adult women with PTSD.
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Phosphatidylethanolamine Deficiency and Triglyceride Overload in Perilesional Cortex Contribute to Non-Goal-Directed Hyperactivity after Traumatic Brain Injury in Mice
Lisa Hahnefeld,Alexandra Vogel,Robert Gurke,Gerd Geisslinger,Michael K. E. Schäfer,Irmgard Tegeder +5 more
TL;DR: The analyses suggest that TG overload and HexCer and PE deficiencies contributed to behavioral dimensions of post-TBI psychopathology.
References
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Isolation and structure of a brain constituent that binds to the cannabinoid receptor
William A. Devane,Lumir Hanus,Aviva Breuer,Roger G. Pertwee,Lesley A. Stevenson,Graeme Griffin,Dan Gibson,Asher Mandelbaum,A. Etinger,Raphael Mechoulam +9 more
TL;DR: In this article, an arachidonylethanthanolamide (anandamide) was identified in a screen for endogenous ligands for the cannabinoid receptor and its structure was determined by mass spectrometry and nuclear magnetic resonance spectroscopy and confirmed by synthesis.
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Structure of a cannabinoid receptor and functional expression of the cloned cDNA
TL;DR: The cloning and expression of a complementary DNA that encodes a G protein-coupled receptor that is involved in cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana are suggested.
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Molecular characterization of a peripheral receptor for cannabinoids
TL;DR: The cloning of a receptor for cannabinoids is reported that is not expressed in the brain but rather in macrophages in the marginal zone of spleen, which helps clarify the non-psychoactive effects of cannabinoids.
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2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain
Takayuki Sugiura,Sachiko Kondo,Akihiro Sukagawa,Shinji Nakane,A. Shinoda,K. Itoh,Atsushi Yamashita,Keizo Waku +7 more
TL;DR: 2-Arachidonoylglycerol was shown to bind appreciably to the cannabinoid receptor in competitive inhibition experiments and may be an endogenous cannabinoid receptor ligand in the brain.
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A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol
TL;DR: It is revealed that approximately 85% of brain 2-AG hydrolase activity can be ascribed to MAGL, and that the remaining 15% is mostly catalyzed by two uncharacterized enzymes, ABHD6 and ABHD12.