Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond
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TLDR
The ways in which S1P might be therapeutically targeted are discussed — for example, via the development of chemical inhibitors that target the generation, transport and degradation of S 1P and via thedevelopment of specific S1p receptor agonists.Abstract:
The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has been implicated in disorders such as cancer and inflammatory diseases. This Review discusses the ways in which S1P might be therapeutically targeted — for example, via the development of chemical inhibitors that target the generation, transport and degradation of S1P and via the development of specific S1P receptor agonists. We also highlight recent conflicting results observed in preclinical studies targeting S1P and discuss ongoing clinical trials in this field.read more
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Dissertation
Translation of sphingosine-1-phosphate-dependent regulation of myogenic tone in human resistance arteries with heart failure
TL;DR: Results show molecular expression of S 1P signalling components and S1P signalling-dependent regulation of the myogenic response in human resistance arteries and demonstrate potential vascular bed or coronary artery disease-dependent differences.
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Sphingosine-1-phosphate alleviates irradiation-induced parotid injury in a miniature pig model
TL;DR: S1P may partially alleviate IR-induced parotid dysfunction by decreasing apoptosis of microvascular endothelial cells and maintaining the blood flow rate.
The Group IVA Cytosolic Phospholipase A2/C1P Interaction and Its Role in Eicosanoid Synthesis and Inflammation
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Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells.
TL;DR: In this paper, the authors explore the oncogenic functions of sphingosine kinase 1 in human cancers and summarize current research findings of SPHK1 signaling with a focus on breast cancer.
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High Circulating Sphingosine 1-Phosphate is a Risk Factor for Osteoporotic Fracture Independent of Fracture Risk Assessment Tool.
Seung Hun Lee,Jee Yang Lee,Kyeong-Hye Lim,Young-Sun Lee,Seong-Hee Kim,Sooyoung Choi,Seong-Hwan Cho,Jung-Min Koh +7 more
TL;DR: S1P is a consistent and significant risk factor of OF independent of FRAx, especially in subjects with osteopenia and low FRAX probability, and adding S1P levels to FRAZ probabilities improved the area under the receiver-operating characteristics curve (AUC) for OF.
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Liming Sun,Huayi Wang,Zhigao Wang,Sudan He,She Chen,Daohong Liao,Lai Wang,Jiacong Yan,Weilong Liu,Xiaoguang Lei,Xiaodong Wang +10 more
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