Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond
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TLDR
The ways in which S1P might be therapeutically targeted are discussed — for example, via the development of chemical inhibitors that target the generation, transport and degradation of S 1P and via thedevelopment of specific S1p receptor agonists.Abstract:
The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has been implicated in disorders such as cancer and inflammatory diseases. This Review discusses the ways in which S1P might be therapeutically targeted — for example, via the development of chemical inhibitors that target the generation, transport and degradation of S1P and via the development of specific S1P receptor agonists. We also highlight recent conflicting results observed in preclinical studies targeting S1P and discuss ongoing clinical trials in this field.read more
Citations
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Mechanisms of sphingosine 1-phosphate receptor signalling in cancer.
TL;DR: There is strong evidence implicating the involvement of S1P receptors (S1PRs) in cancer progression and the recent evidence to suggest cross-talk between the S1 PRs and other cellular signalling pathways in cancer.
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Resistance of Cancer Cells to Targeted Therapies Through the Activation of Compensating Signaling Loops
Viktoria von Manstein,Chul Min Yang,Diane Richter,Natalia Delis,Vida Vafaizadeh,Bernd Groner +5 more
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Non-coding RNAs: the new central dogma of cancer biology.
TL;DR: A comprehensive review of the various ncRNAs and their functional roles in cancer, and the pre-clinical and clinical development of ncRNA-based therapeutics is provided.
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Sphingosine 1-phosphate Receptor Modulator Therapy for Multiple Sclerosis: Differential Downstream Receptor Signalling and Clinical Profile Effects
TL;DR: The S1P pathway, the characteristics and S1PR binding profiles of S1 PR modulators, the mechanisms of action of S2PR modulators with regard to immune cell trafficking and neuroprotection in MS are reviewed, together with a summary of the clinical effectiveness of the S1pr modulators that are approved or in late-stage development for patients with MS.
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Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy
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