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Journal ArticleDOI

The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies

TLDR
The results show that estimates of ADHD's persistence rely heavily on how one defines persistence, yet, regardless of definition, the analyses show that evidence for ADHD lessens with age.
Abstract
Background. This study examined the persistence of attention deficit hyperactivity disorder (ADHD) into adulthood.Method. We analyzed data from published follow-up studies of ADHD. To be included in the analysis, these additional studies had to meet the following criteria: the study included a control group and it was clear from the methods if the diagnosis of ADHD included subjects who did not meet full criteria but showed residual and impairing signs of the disorder. We used a meta-analysis regression model to separately assess the syndromatic and symptomatic persistence of ADHD.Results. When we define only those meeting full criteria for ADHD as having ‘persistent ADHD’, the rate of persistence is low, ~15% at age 25 years. But when we include cases consistent with DSM-IV's definition of ADHD in partial remission, the rate of persistence is much higher, ~65%.Conclusions. Our results show that estimates of ADHD's persistence rely heavily on how one defines persistence. Yet, regardless of definition, our analyses show that evidence for ADHD lessens with age. More work is needed to determine if this reflects true remission of ADHD symptoms or is due to the developmental insensitivity of diagnostic criteria for the disorder.

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Citations
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Journal ArticleDOI

The epidemiology and global burden of autism spectrum disorders

TL;DR: There was no clear evidence of a change in prevalence for autistic disorder or other ASDs between 1990 and 2010 and Worldwide, there was little regional variation in the prevalence of ASDs.
Journal ArticleDOI

Young adult outcome of attention deficit hyperactivity disorder: a controlled 10-year follow-up study.

TL;DR: By their young adult years, ADHD youth were at high risk for a wide range of adverse psychiatric outcomes including markedly elevated rates of antisocial, addictive, mood and anxiety disorders.
Journal ArticleDOI

Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis

Martine Hoogman, +92 more
TL;DR: Lifespan analyses suggest that, in the absence of well powered longitudinal studies, the ENIGMA cross-sectional sample across six decades of ages provides a means to generate hypotheses about lifespan trajectories in brain phenotypes.
Journal ArticleDOI

Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder.

TL;DR: In this paper, a meta-analysis including all regions across all studies indicated global reductions for ADHD subjects compared with control subjects, standardized mean difference =.408, p Conclusions This meta analysis provides a quantitative analysis of neuroanatomical abnormalities in ADHD and information can be used to guide future studies.
References
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The behavior of maximum likelihood estimates under nonstandard conditions

TL;DR: In this paper, the authors prove consistency and asymptotic normality of maximum likelihood estimators under weaker conditions than usual, such that the true distribution underlying the observations belongs to the parametric family defining the estimator, and the regularity conditions do not involve the second and higher derivatives of the likelihood function.
Journal Article

The worldwide prevalence of ADHD: is it an American condition?

TL;DR: Analysis of the available data suggests that the prevalence of ADHD is at least as high in many non-US children as in US children, with the highest prevalence rates being seen when using DSM-IV diagnoses.
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The Adolescent Outcome of Hyperactive Children Diagnosed by Research Criteria: I. An 8-Year Prospective Follow-up Study

TL;DR: The use of research criteria for diagnosing children as hyperactive identifies a pattern of behavioral symptoms that is highly stable over time and associated with considerably greater risk for family disturbance and negative academic and social outcomes in adolescence than has been previously reported.
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Adult Outcome of Hyperactive Boys: Educational Achievement, Occupational Rank, and Psychiatric Status

TL;DR: The adolescent outcome of this cohort found that these disturbances were dependent on the continuation of ADHD symptoms, and in adulthood, antisocial and drug disorders appeared, in part, independent of sustained ADHD.
Journal ArticleDOI

Age-Dependent Decline of Symptoms of Attention Deficit Hyperactivity Disorder: Impact of Remission Definition and Symptom Type

TL;DR: These results indicate that differences in reported remission rates reflect the definition used rather than the disorder's course, and provide systematic support for the clinical observation that hyperactivity and impulsivity symptoms tend to decline at a higher rate than inattention symptoms.
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