Journal ArticleDOI
The biphasic function of microglia in ischemic stroke.
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TLDR
The mechanisms involved in regulating microglia activation and polarization were reviewed and the role of microRNAs and transplanted stem cells in mediating microgliancation and polarization during brain ischemia was studied.About:
This article is published in Progress in Neurobiology.The article was published on 2017-10-01. It has received 466 citations till now. The article focuses on the topics: Neuroinflammation & Microglia.read more
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A lineage of myeloid cells independent of Myb and hematopoietic stem cells
Elisa Gomez Perdiguero,Christian Schulz,Laurent Chorro,Heather L. Szabo-Rogers,Nicolas Cagnard,Katrin Kierdorf,Marco Prinz,Bishan Wu,Jacobsen Sew.,Jeffrey W. Pollard,Jon Frampton,Karen J. Liu,Frederic Geissmann +12 more
TL;DR: Schulz et al. as discussed by the authors investigated whether adult macrophages all share a common developmental origin and found that a population of yolk-sac-derived, tissue-resident macophages was able to develop and persist in adult mice in the absence of hematopoietic stem cells.
Journal ArticleDOI
M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124.
Yaying Song,Zongwei Li,Tingting He,Meijie Qu,Lu Jiang,Wanlu Li,Xiaojing Shi,Jiaji Pan,Linyuan Zhang,Yongting Wang,Zhijun Zhang,Yaohui Tang,Guo-Yuan Yang +12 more
TL;DR: It is demonstrated that M2 microglia-derived exosomes attenuated ischemic brain injury and promoted neuronal survival via exosomal miR-124 and its downstream target USP14.
Journal ArticleDOI
Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke.
TL;DR: Although future translational studies are required, M2-like microglia and monocytes/macrophages therapies are attractive for managing stroke based on their protective functions.
Journal ArticleDOI
Glial Cells: Role of the Immune Response in Ischemic Stroke.
TL;DR: The mechanisms of post-stroke immune regulation mediated by glial cells and the interaction between glia cells and neurons are discussed and the potential roles of variousglial cells at different stages of ischemic stroke are described.
Journal ArticleDOI
Dual Functions of Microglia in Ischemic Stroke
Chuan Qin,Luo Qi Zhou,Xiao Tong Ma,Zi Wei Hu,Sheng Yang,Man Chen,Dale B. Bosco,Long Jun Wu,Dai Shi Tian +8 more
TL;DR: It is suggested that microglial activation is also critical for neurogenesis, angiogenesis, and synaptic remodeling, thereby promoting functional recovery after cerebral ischemia and the possible mechanisms controlling the post-ischemic activity of microglia.
References
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Alternative activation of macrophages
TL;DR: The evidence in favour of alternative macrophage activation by the TH2-type cytokines interleukin-4 (IL-4) and IL-13 is assessed, and its limits and relevance to a range of immune and inflammatory conditions are defined.
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The chemokine system in diverse forms of macrophage activation and polarization.
Alberto Mantovani,Alberto Mantovani,Antonio Sica,Silvano Sozzani,Silvano Sozzani,Paola Allavena,Annunciata Vecchi,Massimo Locati +7 more
TL;DR: Recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.
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Role of AMP-activated protein kinase in mechanism of metformin action
Gaochao Zhou,Robert W. Myers,Ying Li,Yuli Chen,Xiaolan Shen,Judy Fenyk-Melody,Margaret Wu,John Ventre,Thomas W. Doebber,Nobuharu Fujii,Nicolas Musi,Michael F. Hirshman,Laurie J. Goodyear,David E. Moller +13 more
TL;DR: It is reported that metformin activates AMPK in hepatocytes; as a result, acetyl-CoA carboxylase (ACC) activity is reduced, fatty acid oxidation is induced, and expression of lipogenic enzymes is suppressed.
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Monocyte and macrophage heterogeneity
Siamon Gordon,Philip R. Taylor +1 more
TL;DR: Recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues.
Journal ArticleDOI
Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo
TL;DR: Using in vivo two-photon imaging in neocortex, it is found that microglial cells are highly active in their presumed resting state, continually surveying their microenvironment with extremely motile processes and protrusions.