Journal ArticleDOI
The complex interplay between autophagy and cell death pathways
TLDR
In this article , the authors survey both earlier and recent findings, highlighting the intricate interaction of autophagic and cell death pathways, and discuss paradigms where this cross-talk is disrupted, in the context of disease.Abstract:
Autophagy is a universal cellular homeostatic process, required for the clearance of dysfunctional macromolecules or organelles. This self-digestion mechanism modulates cell survival, either directly by targeting cell death players, or indirectly by maintaining cellular balance and bioenergetics. Nevertheless, under acute or accumulated stress, autophagy can also contribute to promote different modes of cell death, either through highly regulated signalling events, or in a more uncontrolled inflammatory manner. Conversely, apoptotic or necroptotic factors have also been implicated in the regulation of autophagy, while specific factors regulate both processes. Here, we survey both earlier and recent findings, highlighting the intricate interaction of autophagic and cell death pathways. We, Furthermore, discuss paradigms, where this cross-talk is disrupted, in the context of disease. read more
Citations
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Impaired autophagy promotes hair loss in the C3H/HeJ mouse model of alopecia areata
Rupali Gund,Angela M. Christiano +1 more
TL;DR: The involvement of impaired autophagy in disease pathogenesis of AA is suggested, as indicated by the finding that autophagic activity is inhibited in the HF of AA mice.
Journal ArticleDOI
An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma
Odai Darawshi,Barbara Muz,Shiri Gershon Naamat,Bellam Praveen,Mohamed Mahameed,Karin Goldberg,Priya Dipta,Miriam Shmuel,Francesca Forno,Shatha Boukeileh,Hadas Tamar Pahima,Julia Hermann,Marc S. Raab,Alexandra M Poos,Niels Weinhold,Chaggai Rosenbluh,Moshe E. Gatt,Wilhelm Palm,Abdel Kareem Azab,Boaz Tirosh +19 more
TL;DR: In this paper , the inactivation of mTORC1 is an intrinsic response of multiple myeloma (MM) to proteasome inhibitors (PIs), and the drug PMA is a robust inducer of m TORC1 activity, which synergized with PIs in inducing MM cell death.
Journal ArticleDOI
The Role of Hydrogen Sulfide Targeting Autophagy in the Pathological Processes of the Nervous System
TL;DR: This review summarizes the recent literatures on the role of H2S in the pathological process of the nervous system by regulating autophagy, and analyzes the mechanism in detail to provide the reference for future related research.
Journal ArticleDOI
Co-targeting triple-negative breast cancer cells and endothelial cells by metronomic chemotherapy inhibits cell regrowth and migration via downregulation of the FAK/VEGFR2/VEGF axis and autophagy/apoptosis activation
Arianna Scagliotti,Laura Capizzi,Marina Cazzaniga,Alice Ilari,Marco De Giorgi,Nicoletta Cordani,Matteo Gallazzi,Antonino Bruno,Giuseppe Pelosi,Adriana Albini,Marialuisa Lavitrano,Emanuela Grassilli,Maria Grazia Cerrito +12 more
TL;DR: In this paper , the anti-metastatic and anti-angiogenic potential of metronomic 5-Fluorouracil plus Vinorelbine (5-FU+VNR) in comparison to standard treatment (STD) was investigated.
Journal ArticleDOI
Deregulation of Autophagy and Apoptosis in Patients with Myelodysplastic Syndromes: Implications for Disease Development and Progression
Andreas Agathangelidis,Christina-Nefeli Kontandreopoulou,M. Stavropoulou,Panagiotis T. Diamantopoulos,Nora Viniou,Vassiliki Aleporou,Issidora S. Papassideri,Panagoula Kollia +7 more
TL;DR: In this paper , the role of autophagy and apoptosis in the pathogenesis and progression of myelodysplastic neoplasms (MDSs) was investigated.
References
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Journal ArticleDOI
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu,Satoshi Waguri,Satoshi Waguri,Tomoki Chiba,Shigeo Murata,Junichi Iwata,Junichi Iwata,Isei Tanida,Takashi Ueno,Masato Koike,Yasuo Uchiyama,Eiki Kominami,Keiji Tanaka +12 more
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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor.
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