The crystal structure of the intact E. coli RelBE toxin-antitoxin complex provides the structural basis for conditional cooperativity.
Andreas Bøggild,Nicholas Sofos,Kasper R. Andersen,Ane Feddersen,Ashley D. Easter,Lori A. Passmore,Ditlev E. Brodersen +6 more
TLDR
The crystal structure of the intact Escherichia coli RelB2E2 complex at 2.8 Å resolution provides a firm basis for understanding the model of conditional cooperativity at the molecular level and supports a model in which relO is optimally bound by two adjacent RelB 2E heterotrimeric units, and is not compatible with concomitant binding of two RelB1E2 heterotetramers.About:
This article is published in Structure.The article was published on 2012-10-10 and is currently open access. It has received 93 citations till now. The article focuses on the topics: Toxin-antitoxin complex & RELB.read more
Citations
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Toxin-antitoxin systems in bacterial growth arrest and persistence
Rebecca Page,Wolfgang Peti +1 more
TL;DR: This Review highlights recent discoveries of these multifaceted TA systems with a focus on the newly uncovered mechanisms, especially conditional cooperativity, that are used to regulate cell growth and persistence and the potential for targeting TA systems for antimicrobial drug discovery.
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Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology
TL;DR: How multiple levels of regulation shape the conditions of toxin activation to achieve the different biological functions of TA modules is highlighted.
Journal ArticleDOI
Toxin–antitoxin systems: Biology, identification, and application
TL;DR: Toxin–antitoxin systems are small genetic elements composed of a toxin gene and its cognate antitoxin and their potential to combat viral infection may aid in controlling infectious diseases.
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Toxin-antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate
TL;DR: Five types of TA systems have been proposed that differ markedly in their genetic architectures and modes of activity control, and may aid in combating infectious diseases.
Journal ArticleDOI
The bacterial translation stress response
TL;DR: Understanding the mechanism of how the bacterial cell responds to stress will not only provide fundamental insight into translation regulation, but will also be an important step to identifying new targets for the development of novel antimicrobial agents.
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