Journal ArticleDOI
The cytotoxicity and mechanisms of 1,2-naphthoquinone thiosemicarbazone and its metal derivatives against MCF-7 human breast cancer cells.
Junnan Chen,Yue-Wern Huang,Guanshu Liu,Zahra Afrasiabi,Ekkehard Sinn,Subhash Padhye,Yinfa Ma +6 more
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TLDR
Investigation of the antitumor functions and mechanisms of 1,2-naphthoquinone-2-thiosemicarbazone and its metal complexes against MCF-7 human breast cancer cells revealed that these complexes are effective antitumors chemicals in inhibiting MCf-7 cell growth, with Ni-NQTS being the most effective among the complexes studied.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 2004-05-15. It has received 127 citations till now. The article focuses on the topics: Topoisomerase-II Inhibitor & Topoisomerase.read more
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Advances in copper complexes as anticancer agents.
Carlo Santini,Maura Pellei,Valentina Gandin,Marina Porchia,Francesco Tisato,Cristina Marzano +5 more
Journal ArticleDOI
Nickel (II) complexes of naphthaquinone thiosemicarbazone and semicarbazone: synthesis, structure, spectroscopy, and biological activity.
TL;DR: In vitro anticancer studies on MCF-7 human breast cancer cells reveal that the semicarbazone derivative along with its nickel complex is more active in the inhibition of cell proliferation than the thiosemicarbazones analogue.
Journal ArticleDOI
A Series of α-Heterocyclic Carboxaldehyde Thiosemicarbazones Inhibit Topoisomerase IIα Catalytic Activity
He Huang,Qin Chen,Xin Ku,Linghua Meng,Liping Lin,Xiang Wang,Caihua Zhu,Yi Wang,Zhi Chen,Ming Li,Hualiang Jiang,Kaixian Chen,Jian Ding,Hong Liu +13 more
TL;DR: Results about the mechanisms involved in the anticancer activities of thiosemicarbazones will aid in the rational design of novel topoisomerase II-targeted drugs and will provide insights into the discovery and development of novel cancer therapeutics based on the dual activity to chelate iron and to inhibit the catalytic activity of topoisomersase IIalpha.
Journal ArticleDOI
Role of metalation in the topoisomerase IIα inhibition and antiproliferation activity of a series of α-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes.
TL;DR: The topoisomerase-IIα inhibition and antiproliferative activity of α-heterocyclic thiosemicarbazones and their corresponding copper(II) complexes have been investigated and copper complexes were shown to inhibit the proliferation of breast cancer cells expressing high levels of the enzyme.
References
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New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
Philip Skehan,Ritsa Storeng,Dominic A. Scudiero,Anne Monks,James B. McMahon,David T. Vistica,Jonathan T. Warren,Heidi R. Bokesch,Susan Kenney,Michael R. Boyd +9 more
TL;DR: The SRB assay provides a sensitive measure of drug-induced cytotoxicity, is useful in quantitating clonogenicity, and is well suited to high-volume, automated drug screening.
Journal ArticleDOI
Etoposide: four decades of development of a topoisomerase II inhibitor
TL;DR: The history of the development of one of the first identified topoisomerase II inhibitors, etoposide, is reviewed and critical developments in etopose's mechanism of action, pharmacology and administration schedule are summarised.
Journal Article
Etoposide-induced Apoptosis in Human HL-60 Cells Is Associated with Intracellular Acidification
TL;DR: The results demonstrate the involvement of DNase II in apoptotic DNA digestion and suggest mechanisms of pH homeostasis as regulators of apoptosis.
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The wide pharmacological versatility of semicarbazones, thiosemicarba-zones and their metal complexes.
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