The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages.
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TLDR
The findings suggest that the segregation of extraembryonic and embryonic tissues within the mammalian embryo is not as strict as believed and that a lineage previously defined as exclusively extra embryonic contributes cells to the embryo.About:
This article is published in Developmental Cell.The article was published on 2008-10-14 and is currently open access. It has received 381 citations till now. The article focuses on the topics: Endoderm formation & Definitive endoderm.read more
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Forces in Tissue Morphogenesis and Patterning
TL;DR: The interplay between tissue mechanics and biochemical signaling orchestrates tissue morphogenesis and patterning in development.
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Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
TL;DR: Relevant studies in lower vertebrates indicate the conservation and divergence of regulatory mechanisms for cell lineage allocation and axis patterning in the early mammalian embryo.
Journal ArticleDOI
Vertebrate Endoderm Development and Organ Formation
Aaron M. Zorn,James M. Wells +1 more
TL;DR: This work discusses how developmental mechanisms that regulate endoderm organogenesis are used to direct differentiation of embryonic stem cells into specific adult cell types, which function to alleviate disease symptoms in animal models.
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Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse.
Janet Rossant,Patrick P.L. Tam +1 more
TL;DR: The investigation into lineage allocation and early asymmetries in the pre- and peri-implantation mouse embryo is gaining momentum and new insights have been gained into the cellular and molecular events that lead to the establishment of the three lineages of the blastocyst.
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A single-cell molecular map of mouse gastrulation and early organogenesis.
Blanca Pijuan-Sala,Jonathan A. Griffiths,Carolina Guibentif,Tom W. Hiscock,Wajid Jawaid,Fernando J Calero-Nieto,Carla Mulas,Ximena Ibarra-Soria,Richard C. V. Tyser,Debbie Lee Lian Ho,Wolf Reik,Wolf Reik,Wolf Reik,Shankar Srinivas,Benjamin D. Simons,Jennifer Nichols,John C. Marioni,John C. Marioni,John C. Marioni,Berthold Göttgens +19 more
TL;DR: A comprehensive delineation of mammalian cell differentiation trajectories in vivo represents a baseline for understanding the effects of gene mutations during development, as well as a roadmap for the optimization of in vitro differentiation protocols for regenerative medicine.
References
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A monomeric red fluorescent protein
Robert E. Campbell,Oded Tour,Amy E. Palmer,Paul Steinbach,Geoffrey S. Baird,David A. Zacharias,Roger Y. Tsien +6 more
TL;DR: This work presents the stepwise evolution of DsRed to a dimer and then either to a genetic fusion of two copies of the protein, i.e., a tandem dimer, or to a true monomer designated mRFP1 (monomeric red fluorescent protein).
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Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
TL;DR: Fully potent early passage R1 cells and the R1-S3 subclone should be very useful not only for ES cell-based genetic manipulations but also in defining optimal in vitro culture conditions for retaining the initial totipotency of ES cells.
Book
The Atlas of Mouse Development
TL;DR: Assessment of Developmental Stage of Pre- and Postimplantation Mouse Embryos Based on the Staging System of Theiler (1989) and general Observations on the Urogenital Ridges, Gonads, and Genital Duct System.
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Adherens and tight junctions: structure, function and connections to the actin cytoskeleton.
Andrea Hartsock,W. James Nelson +1 more
TL;DR: The binding interactions of the most studied proteins that occur within each junctional complexes and possible modes of regulation of these interactions are discussed, and the different mechanisms that connect and regulate interactions with the actin cytoskeleton are discussed.