The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection.
Lisa Henss,Arne Auste,Christoph Schürmann,Christin Schmidt,Christine von Rhein,Michael D. Mühlebach,Barbara S. Schnierle +6 more
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In this paper, the authors examined whether EGCG has antiviral activity against SARS-CoV-2 and found that EGCg blocked not only the entry of SARS, but also MERS- and SARS CoV pseudotyped lentiviral vectors and inhibited virus infections in vitro.Abstract:
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has caused a pandemic with tens of millions of cases and more than a million deaths. The infection causes COVID-19, a disease of the respiratory system of divergent severity. No treatment exists. Epigallocatechin-3-gallate (EGCG), the major component of green tea, has several beneficial properties, including antiviral activities. Therefore, we examined whether EGCG has antiviral activity against SARS-CoV-2. EGCG blocked not only the entry of SARS-CoV-2, but also MERS- and SARS-CoV pseudotyped lentiviral vectors and inhibited virus infections in vitro. Mechanistically, inhibition of the SARS-CoV-2 spike-receptor interaction was observed. Thus, EGCG might be suitable for use as a lead structure to develop more effective anti-COVID-19 drugs.read more
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Potential protective mechanisms of green tea polyphenol EGCG against COVID-19
TL;DR: In this paper, the potential protective effects of (−)-epigallocatechin-3-gallate (EGCG), a major constituent of green tea, against COVID-19 was discussed.
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Tea and coffee polyphenols and their biological properties based on the latest in vitro investigations
TL;DR: In this paper , the authors present the activity of polyphenols found in different types of tea and coffee and describe the effects of tea fermentation and coffee roasting on their polyphenol composition and antioxidant properties.
Journal ArticleDOI
Tea and coffee polyphenols and their biological properties based on the latest in vitro investigations
TL;DR: In this article, the authors present the activity of polyphenols found in different types of tea and coffee and describe the effects of tea fermentation and coffee roasting on their polyphenol composition and antioxidant properties.
Journal ArticleDOI
Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review.
TL;DR: In this paper, the effects of flavonoids on various key SARS-CoV-2 targets were analyzed and an analysis of the structure-activity relationships for the same was presented.
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A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV.
Sitesh C. Bachar,Kishor Mazumder,Kishor Mazumder,Kishor Mazumder,Ritesh Bachar,Asma Aktar,Mamun Al Mahtab +6 more
TL;DR: A review of 46 medicinal plants with antiviral activity from 25 families is presented in this paper, where the authors discuss mechanistic insights into their bioactive components against three most hazardous viruses, namely SARS-CoV-2, HIV, and HBV.
References
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