Journal ArticleDOI
The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARα; and repressed by C/EBPα: Implications in FABP1 down-regulation in nonalcoholic fatty liver disease.
Carla Guzmán,Marta Benet,Sandra Pisonero-Vaquero,Marta Moya,M. Victoria García-Mediavilla,M. Luz Martínez-Chantar,Javier González-Gallego,José V. Castell,Sonia Sánchez-Campos,Ramiro Jover +9 more
Reads0
Chats0
TLDR
It is concluded that human FABP1 has a complex mechanism of regulation where C/EBPα displaces HNF4α and hampers activation by FOXA1 and PPARα.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-04-01. It has received 75 citations till now. The article focuses on the topics: adipocyte protein 2 & Fatty acid.read more
Citations
More filters
Journal ArticleDOI
Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation
David Porras,Esther Nistal,Susana Martínez-Flórez,Sandra Pisonero-Vaquero,José Luis Olcoz,Ramiro Jover,Ramiro Jover,Javier González-Gallego,Javier González-Gallego,María Victoria García-Mediavilla,María Victoria García-Mediavilla,Sonia Sánchez-Campos,Sonia Sánchez-Campos +12 more
TL;DR: The suitability of quercetin as a therapeutic approach for obesity‐associated NAFLD via its anti‐inflammatory, antioxidant and prebiotic integrative response is supported.
Journal ArticleDOI
Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae
Jing Yuan,Chen Chen,Jinghua Cui,Jing Lu,Chao Yan,Xiao Wei,Xiangna Zhao,Nannan Li,Shaoli Li,Guanhua Xue,Weiwei Cheng,Boxing Li,Huan Li,Weishi Lin,Changyu Tian,Jiangtao Zhao,Juqiang Han,Daizhi An,Qiong Zhang,Hong Wei,Ming-Hua Zheng,Xuejun Ma,Wei Li,Xiao Chen,Zheng Zhang,Hui Zeng,Sun Ying,JianXin Wu,Ruifu Yang,Di Liu +29 more
TL;DR: It is shown that high-alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) is associated with up to 60% of individuals with NAFLD in a Chinese cohort, and an alteration in the gut microbiome drives the condition due to excess endogenous alcohol production.
Journal ArticleDOI
Molecular mechanisms of hepatic apoptosis.
TL;DR: Therapeutic options of liver injury are impacted by the clear understanding toward mechanisms of hepatic apoptosis, and the progression of liver disease is affected by the balance between apoptotic and antiapoptotic capabilities.
Journal ArticleDOI
Fatty acid binding proteins: tissue-specific functions in health and disease.
TL;DR: Increasing evidence supports the role of FABPs as important controllers of global metabolism, with their dysregulation being linked to a host of metabolic diseases.
Journal ArticleDOI
Recent insights into the biological functions of liver fatty acid binding protein 1
GuQi Wang,GuQi Wang,GuQi Wang,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Andrew de Lemos,Andrew de Lemos,Frank J. Burczynski +8 more
TL;DR: The role of FABp1 in substrate availability and in protection from oxidative stress suggests that FABP1 plays a pivotal role during intracellular bacterial/viral infections by reducing inflammation and the adverse effects of starvation (energy deficiency).
References
More filters
Journal ArticleDOI
MatInspector and beyond: promoter analysis based on transcription factor binding sites
Kerstin Cartharius,Kornelie Frech,Korbinian Grote,Bernward Klocke,M. Haltmeier,Andreas Klingenhoff,Matthias Frisch,M. Bayerlein,Thomas Werner +8 more
TL;DR: A new version of the program MatInspector is presented that identifies TFBS in nucleotide sequences using a large library of weight matrices using a matrix family concept, optimized thresholds, and comparative analysis and produces concise results avoiding redundant and false-positive matches.
Journal ArticleDOI
The natural history of nonalcoholic fatty liver: A follow-up study
TL;DR: In the absence of preexisting fibrosis or steatohepatitis, fatty liver of nonalcohol‐induced origin is an extremely benign condition.
Journal ArticleDOI
Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites
TL;DR: The lipotoxic liver injury hypothesis for the pathogenesis of NASH suggests that the authors need to focus therapeutic efforts on reducing the burden of fatty acids going to the liver or being synthesized in the liver by improving insulin sensitivity at the level of adipose tissue to prevent inappropriate peripheral lipolysis.
Journal ArticleDOI
Transcriptional Regulation of Metabolism
TL;DR: This review reviews data on the transcriptional regulation of the intermediary metabolism, i.e., glucose, amino acid, lipid, and cholesterol metabolism and discusses how transcription factors integrate signals from various pathways to ensure homeostasis.
Journal ArticleDOI
Tissue-specific transcriptional regulation has diverged significantly between human and mouse.
Duncan T. Odom,Robin D. Dowell,Elizabeth S Jacobsen,William Gordon,Timothy Danford,Kenzie D MacIsaac,P. Alexander Rolfe,Caitlin M. Conboy,David K. Gifford,Ernest Fraenkel +9 more
TL;DR: It is demonstrated that the binding sites for highly conserved transcription factors vary extensively between human and mouse, and from 41% to 89% of their binding events seem to be species specific.