The need to innovate sample collection and library generation in microbial drug discovery: a focus on academia
TLDR
This viewpoint will discuss limitations of sample collection and microbial strain library generation practices and offer suggestions to innovate these areas, particularly through the targeted cultivation of several understudied bacterial phyla and the untargeted use of mass spectrometry and bioinformatics to generate diverse microbial libraries.About:
This article is published in Natural Product Reports.The article was published on 2021-03-04 and is currently open access. It has received 13 citations till now. The article focuses on the topics: Sample collection.read more
Citations
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A marine microbiome antifungal targets urgent-threat drug-resistant fungi
Fan Zhang,Miao Zhao,Doug R. Braun,Spencer S. Ericksen,Jeff S. Piotrowski,Justin Nelson,Jian Peng,Gene E. Ananiev,Shaurya Chanana,Kenneth J. Barns,Jen Fossen,Hiram Sanchez,Marc G. Chevrette,Ilia A. Guzei,Changgui Zhao,Le Guo,Weiping Tang,Cameron R. Currie,Scott R. Rajski,Anjon Audhya,David R. Andes,Tim S. Bugni +21 more
TL;DR: The most promising lead, turbinmicin, displays potent in vitro and mouse-model efficacy toward multiple-drug–resistant fungal pathogens, exhibits a wide safety index, and functions through a fungal-specific mode of action, targeting Sec14 of the vesicular trafficking pathway.
Journal ArticleDOI
How different are marine microbial natural products compared to their terrestrial counterparts
TL;DR: In this paper, a cluster analysis of chemical fingerprints and molecular scaffold analysis of 55 817 compounds reported from marine and terrestrial microorganisms, and marine macro-organisms showed that 76.7% of the compounds isolated from marine microorganisms are closely related to compounds extracted from terrestrial micro organisms.
Journal ArticleDOI
How different are marine microbial natural products compared to their terrestrial counterparts?
TL;DR: In this paper , a cluster analysis of chemical fingerprints and molecular scaffold analysis of 55 817 compounds reported from marine and terrestrial microorganisms, and marine macro-organisms showed that 76.7% of the compounds isolated from marine microorganisms are closely related to compounds identified from terrestrial micro organisms.
Posted ContentDOI
Genome-guided discovery of natural products through multiplexed low coverage whole-genome sequencing of soil Actinomycetes on Oxford Nanopore Flongle
TL;DR: In this article, a low-cost DNA sequencing option was proposed to obtain contiguous DNA assemblies and identify large (ca. 10 to greater than 100 Kb) biosynthetic gene clusters (BGCs) with high-GC (>70%) and repeat content.
Journal ArticleDOI
Evaluating the Distribution of Bacterial Natural Product Biosynthetic Genes across Lake Huron Sediment.
TL;DR: In this paper, the geographic occurrence of NP ketosynthase (KS) and adenylation (A) domains was documented across 53 and 58 surface sediment samples, respectively, covering 59,590 square kilometers of Lake Huron.
References
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Journal ArticleDOI
The evolving role of natural products in drug discovery
Frank E. Koehn,Guy T. Carter +1 more
TL;DR: Recent technological advances that help to address issues such as the lack of compatibility of traditional natural-product extract libraries with high-throughput screening and unrealized expectations from current lead-generation strategies have led to a renewed interest in natural products in drug discovery.
Journal ArticleDOI
A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life
Donovan H. Parks,Maria Chuvochina,David W. Waite,Christian Rinke,Adam Skarshewski,Pierre-Alain Chaumeil,Philip Hugenholtz +6 more
TL;DR: This work used a concatenated protein phylogeny as the basis for a bacterial taxonomy that conservatively removes polyphyletic groups and normalizes taxonomic ranks on the basis of relative evolutionary divergence.
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A new antibiotic kills pathogens without detectable resistance
Losee Lucy Ling,Tanja Schneider,Aaron J. Peoples,Amy Spoering,Ina Engels,Brian P. Conlon,A. Mueller,Till F. Schäberle,Dallas Hughes,Slava S. Epstein,M. Jones,Linos Lazarides,Victoria Alexandra Steadman,Cohen Dr,Cintia R. Felix,Fetterman Ka,William Millett,Anthony Nitti,Ashley Zullo,Chao Chen,Kim Lewis +20 more
TL;DR: The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance, as well as several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors.
Journal ArticleDOI
A brief history of the antibiotic era: lessons learned and challenges for the future.
TL;DR: This article gives a very brief overview of the antibiotic era, beginning from the discovery of first antibiotics until the present day situation, which is marred by the emergence of hard-to-treat multiple antibiotic-resistant infections.
Journal ArticleDOI
Developing a new resource for drug discovery: marine actinomycete bacteria
William Fenical,Paul R. Jensen +1 more
TL;DR: The continued development of improved cultivation methods and technologies for accessing deep-sea environments promises to provide access to this significant new source of chemical diversity.
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