Journal ArticleDOI
The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics
Reads0
Chats0
TLDR
This Review discusses the emerging important biological functions of the nitrate–nitrite–NO pathway, and highlights studies that implicate the therapeutic potential of nitrate and nitrite in conditions such as myocardial infarction, stroke, systemic and pulmonary hypertension, and gastric ulceration.Abstract:
The inorganic anions nitrate (NO3-) and nitrite (NO2-) were previously thought to be inert end products of endogenous nitric oxide (NO) metabolism However, recent studies show that these supposedly inert anions can be recycled in vivo to form NO, representing an important alternative source of NO to the classical L-arginine-NO-synthase pathway, in particular in hypoxic states This Review discusses the emerging important biological functions of the nitrate-nitrite-NO pathway, and highlights studies that implicate the therapeutic potential of nitrate and nitrite in conditions such as myocardial infarction, stroke, systemic and pulmonary hypertension, and gastric ulcerationread more
Citations
More filters
Journal ArticleDOI
Microbially mediated coupling of nitrate reduction and Fe(II) oxidation under anoxic conditions.
TL;DR: This review focused on microbially mediated NO3--reducing Fe(II) oxidation (NRFO) under anoxic conditions and comprehensively clarified the roles of the biological and chemical processes involved in NRFO.
Journal ArticleDOI
Physiology: Myoglobin's new clothes.
TL;DR: Gene knockout experiments in mice reveal that myoglobin is the mediator of this effect of nitric oxide generated from the nitrite ion, which limits the tissue damage caused by restricted blood flow.
Journal ArticleDOI
Effects of Beetroot Juice Supplementation on Performance and Fatigue in a 30-s All-Out Sprint Exercise: A Randomized, Double-Blind Cross-Over Study
Eduardo Cuenca,Pablo Jodra,Alberto Pérez-López,Liliana G. González-Rodríguez,Sandro Fernandes da Silva,Pablo Veiga-Herreros,Raúl Domínguez +6 more
TL;DR: It is indicated that while BJ supplementation improved performance at the 30-s cycling sprint, this improvement was not accompanied by differences in fatigue during or after this type of exercise.
Journal ArticleDOI
Acute Beetroot Juice Supplementation Does Not Improve Cycling Performance in Normoxia or Moderate Hypoxia
Kristin E. MacLeod,Sean F. Nugent,Susan I. Barr,Michael S. Koehle,Benjamin C. Sporer,Martin J. MacInnis +5 more
TL;DR: In conclusion, BR did not lower the oxygen cost of steady-state exercise or improve exercise performance in normoxia or hypoxia in a small sample of well-trained male cyclists.
Journal ArticleDOI
Higher endogenous nitrite levels are associated with superior exercise capacity in highly trained athletes.
Matthias Totzeck,Ulrike B. Hendgen-Cotta,Christos Rammos,Lisa-Marie Frommke,Christian Knackstedt,Hans-Georg Predel,Malte Kelm,Tienush Rassaf +7 more
TL;DR: It is shown that higher baseline levels of nitrite are associated with a superior exercise capacity in highly trained athletes independent of endothelial function, and multiple linear regressions showed that baseline plasma nitrite level but not endothelialfunction was an independent predictor of exercise capacity.
References
More filters
Journal ArticleDOI
The L-Arginine-Nitric Oxide Pathway
Salvador Moncada,Annie Higgs +1 more
TL;DR: The discovery that mammalian cells generate nitric oxide, a gas previously considered to be merely an atmospheric pollutant, is providing important information about many biologic processes.
Journal ArticleDOI
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Lawrence J. Appel,Thomas Burton Moore,Thomas Burton Moore,Eva Obarzanek,William M. Vollmer,Laura P. Svetkey,Frank M. Sacks,George A. Bray,Thomas M. Vogt,Jeffrey A. Cutler,Marlene M. Windhauser,Pao-Hwa Lin,Njeri Karanja,Denise G. Simons-Morton,Marjorie L. McCullough,Janis F. Swain,Priscilla Steele,Marguerite Evans,Edgar R. Miller,David W. Harsha +19 more
TL;DR: In this paper, the effects of dietary patterns on blood pressure were assessed in a clinical trial, Dietary Approaches to Stop Hypertension, where the subjects were fed a control diet that was low in fruits, vegetables, and dairy products, with a fat content typical of the average diet in the United States.
Journal ArticleDOI
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation.
Kenyatta Cosby,Kristine S. Partovi,Jack H. Crawford,Rakesh P. Patel,Christopher D. Reiter,Sabrina Martyr,Benjamin K. Yang,Myron A. Waclawiw,Gloria Zalos,Xiuli Xu,Kris T. Huang,Howard Shields,Daniel B. Kim-Shapiro,Alan N. Schechter,Richard O. Cannon,Mark T. Gladwin +15 more
TL;DR: It is suggested that nitrite represents a major bioavailable pool of NO, and a new physiological function for hemoglobin as a nitrite reductase is described, potentially contributing to hypoxic vasodilation.
Journal Article
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.
Louis J. Ignarro,Howard Lippton,J C Edwards,William H. Baricos,Albert L. Hyman,P. J. Kadowitz,Carl A. Gruetter +6 more
Journal ArticleDOI
Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite.
TL;DR: An L-arginine-dependent biochemical pathway synthesizing L-citrulline and nitrite, coupled to an effector mechanism, is shown to cause this pattern of metabolic inhibition in cytotoxic activated macrophages.