Journal ArticleDOI
The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics
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This Review discusses the emerging important biological functions of the nitrate–nitrite–NO pathway, and highlights studies that implicate the therapeutic potential of nitrate and nitrite in conditions such as myocardial infarction, stroke, systemic and pulmonary hypertension, and gastric ulceration.Abstract:
The inorganic anions nitrate (NO3-) and nitrite (NO2-) were previously thought to be inert end products of endogenous nitric oxide (NO) metabolism However, recent studies show that these supposedly inert anions can be recycled in vivo to form NO, representing an important alternative source of NO to the classical L-arginine-NO-synthase pathway, in particular in hypoxic states This Review discusses the emerging important biological functions of the nitrate-nitrite-NO pathway, and highlights studies that implicate the therapeutic potential of nitrate and nitrite in conditions such as myocardial infarction, stroke, systemic and pulmonary hypertension, and gastric ulcerationread more
Citations
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Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of arbutin.
Manal Mohamed Elhassan Taha,Muhammad Saleh Salga,Hapipah Mohd Ali,Mahmood Ameen Abdulla,Siddig Ibrahim Abdelwahab,A. Hamid A. Hadi +5 more
TL;DR: It can be concluded that Turnera diffusa possesses anti-ulcer activity, which could be attributed to lipid peroxidation inhibitory, immuno modulatory and anti-oxidant mechanisms of arbutin but not to the intervention with nitric oxide inflammation pathway.
Journal ArticleDOI
Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase
Rebecca L. Charles,Olena Rudyk,Oleksandra Prysyazhna,Alisa Kamynina,Jun Yang,Christophe Morisseau,Bruce D. Hammock,Bruce A. Freeman,Philip Eaton +8 more
TL;DR: Protection from hypertension afforded by the Mediterranean diet is mediated by nitro-fatty acid-dependent inhibition of soluble epoxide hydrolase, and lipid electrophiles such as NO2-OA mediate antihypertensive signaling actions by inhibiting sEH is suggested.
Journal ArticleDOI
Regulation of Nitric Oxide Production in the Developmental Programming of Hypertension and Kidney Disease
Chien-Ning Hsu,You-Lin Tain +1 more
TL;DR: Clinical studies are required to bridge the gap between animal models and clinical trials in order to develop ideal NO-targeting reprogramming strategies and to be able to have a lifelong impact, with profound savings in the global burden of hypertension and kidney disease.
Journal ArticleDOI
The Identification of Nitric Oxide as Endothelium-Derived Relaxing Factor
TL;DR: The identification of endothelium-derived relaxing factor as nitric oxide (NO) dramatically altered the course of vascular biology, as well as other biomedical disciplines, and provided a rich source of molecular mediators of phenotype in health and disease.
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Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly
TL;DR: It can be concluded that enzymatic production of NO declines steadily with increasing age in healthy human subjects, and implementing strategies to diagnose and treat NO insufficiency may provide enormous benefit to the geriatric patient.
References
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Journal ArticleDOI
The L-Arginine-Nitric Oxide Pathway
Salvador Moncada,Annie Higgs +1 more
TL;DR: The discovery that mammalian cells generate nitric oxide, a gas previously considered to be merely an atmospheric pollutant, is providing important information about many biologic processes.
Journal ArticleDOI
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Lawrence J. Appel,Thomas Burton Moore,Thomas Burton Moore,Eva Obarzanek,William M. Vollmer,Laura P. Svetkey,Frank M. Sacks,George A. Bray,Thomas M. Vogt,Jeffrey A. Cutler,Marlene M. Windhauser,Pao-Hwa Lin,Njeri Karanja,Denise G. Simons-Morton,Marjorie L. McCullough,Janis F. Swain,Priscilla Steele,Marguerite Evans,Edgar R. Miller,David W. Harsha +19 more
TL;DR: In this paper, the effects of dietary patterns on blood pressure were assessed in a clinical trial, Dietary Approaches to Stop Hypertension, where the subjects were fed a control diet that was low in fruits, vegetables, and dairy products, with a fat content typical of the average diet in the United States.
Journal ArticleDOI
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation.
Kenyatta Cosby,Kristine S. Partovi,Jack H. Crawford,Rakesh P. Patel,Christopher D. Reiter,Sabrina Martyr,Benjamin K. Yang,Myron A. Waclawiw,Gloria Zalos,Xiuli Xu,Kris T. Huang,Howard Shields,Daniel B. Kim-Shapiro,Alan N. Schechter,Richard O. Cannon,Mark T. Gladwin +15 more
TL;DR: It is suggested that nitrite represents a major bioavailable pool of NO, and a new physiological function for hemoglobin as a nitrite reductase is described, potentially contributing to hypoxic vasodilation.
Journal Article
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.
Louis J. Ignarro,Howard Lippton,J C Edwards,William H. Baricos,Albert L. Hyman,P. J. Kadowitz,Carl A. Gruetter +6 more
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Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite.
TL;DR: An L-arginine-dependent biochemical pathway synthesizing L-citrulline and nitrite, coupled to an effector mechanism, is shown to cause this pattern of metabolic inhibition in cytotoxic activated macrophages.