Journal ArticleDOI
The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics
Reads0
Chats0
TLDR
This Review discusses the emerging important biological functions of the nitrate–nitrite–NO pathway, and highlights studies that implicate the therapeutic potential of nitrate and nitrite in conditions such as myocardial infarction, stroke, systemic and pulmonary hypertension, and gastric ulceration.Abstract:
The inorganic anions nitrate (NO3-) and nitrite (NO2-) were previously thought to be inert end products of endogenous nitric oxide (NO) metabolism However, recent studies show that these supposedly inert anions can be recycled in vivo to form NO, representing an important alternative source of NO to the classical L-arginine-NO-synthase pathway, in particular in hypoxic states This Review discusses the emerging important biological functions of the nitrate-nitrite-NO pathway, and highlights studies that implicate the therapeutic potential of nitrate and nitrite in conditions such as myocardial infarction, stroke, systemic and pulmonary hypertension, and gastric ulcerationread more
Citations
More filters
Journal ArticleDOI
Ischemia and reperfusion—from mechanism to translation
Holger K. Eltzschig,Tobias Eckle +1 more
TL;DR: Ischemia and reperfusion-elicited tissue injury contributes to morbidity and mortality in a wide range of pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease and sleep apnea as discussed by the authors.
Journal ArticleDOI
The microbial nitrogen-cycling network
TL;DR: This Review summarizes the current understanding of the microbial nitrogen-cycling network, including novel processes, their underlying biochemical pathways, the involved microorganisms, their environmental importance and industrial applications.
Journal ArticleDOI
The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology
TL;DR: The importance of ROS and RNS to plant biology has been relatively little appreciated in the plasma biomedicine community, but it appears that there are opportunities for useful applications of plasmas in this area as well.
Journal ArticleDOI
Food sources of nitrates and nitrites: the physiologic context for potential health benefits
TL;DR: Data call into question the rationale for recommendations to limit nitrate and nitrite consumption from plant foods; a comprehensive reevaluation of the health effects of food sources of nitrates and nitrites is appropriate.
References
More filters
Journal ArticleDOI
Apples increase nitric oxide production by human saliva at the acidic pH of the stomach: A new biological function for polyphenols with a catechol group?
Laura Peri,Donatella Pietraforte,Giuseppe Scorza,Aurora Napolitano,Vincenzo Fogliano,Maurizio Minetti +5 more
TL;DR: It is proposed that some apple polyphenols not only inhibit nitrosation/nitration but also promote *NO bio-availabilty at the gastric level, a previously unappreciated function.
Journal ArticleDOI
Gastrointestinal bacteria generate nitric oxide from nitrate and nitrite.
Tanja Sobko,Claudia Reinders,Emmelie Å. Jansson,Elisabeth Norin,Tore Midtvedt,Jon O. Lundberg +5 more
TL;DR: It is shown that human faeces can generate NO after nitrate or nitrite supplementation, and it is concluded that NO can be generated by the anaerobic gut flora in the presence of nitrateor nitrite.
Journal ArticleDOI
Cardioprotection and mitochondrial S-nitrosation: effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia-reperfusion injury.
TL;DR: Data suggest that mitochondrial S-nitrosation and complex I inhibition constitute a protective signaling pathway that is amenable to pharmacologic augmentation.
Journal ArticleDOI
Serum nitrite sensitively reflects endothelial NO formation in human forearm vasculature: evidence for biochemical assessment of the endothelial L-arginine-NO pathway.
TL;DR: The concentration of serum nitrite sensitively reflects changes in endothelial NO formation in human forearm circulation and may help to characterize the L-arginine-NO pathway in disease states associated with endothelial dysfunction and to further elucidate its pathophysiological significance for the development of atherosclerosis in humans.
Journal ArticleDOI
Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury.
Ryuji Hataishi,Ana Clara Tude Rodrigues,Tomas G. Neilan,John G. Morgan,Emmanuel S. Buys,Sruti Shiva,Rosemary H. Tambouret,Davinder S. Jassal,Michael J. Raher,Elissa Furutani,Fumito Ichinose,Mark T. Gladwin,Anthony Rosenzweig,Warren M. Zapol,Michael H. Picard,Kenneth D. Bloch,Marielle Scherrer-Crosbie +16 more
TL;DR: Breathing 40 or 80 ppm NO markedly and significantly decreased MI size and improved LV function after ischemia and reperfusion in mice, suggesting that NO inhalation may represent a novel method to salvage myocardium at risk of I/R injury.