Journal ArticleDOI
The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics
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TLDR
This Review discusses the emerging important biological functions of the nitrate–nitrite–NO pathway, and highlights studies that implicate the therapeutic potential of nitrate and nitrite in conditions such as myocardial infarction, stroke, systemic and pulmonary hypertension, and gastric ulceration.Abstract:
The inorganic anions nitrate (NO3-) and nitrite (NO2-) were previously thought to be inert end products of endogenous nitric oxide (NO) metabolism However, recent studies show that these supposedly inert anions can be recycled in vivo to form NO, representing an important alternative source of NO to the classical L-arginine-NO-synthase pathway, in particular in hypoxic states This Review discusses the emerging important biological functions of the nitrate-nitrite-NO pathway, and highlights studies that implicate the therapeutic potential of nitrate and nitrite in conditions such as myocardial infarction, stroke, systemic and pulmonary hypertension, and gastric ulcerationread more
Citations
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Journal ArticleDOI
Effect of Blood Nitrite and Nitrate Levels on Murine Platelet Function
TL;DR: The study suggests that endogenous levels of nitrite and nitrate may be used as a biomarker for predicting platelet function and that dietary manipulation may affect thrombotic processes.
Journal ArticleDOI
A stepwise reduction in plasma and salivary nitrite with increasing strengths of mouthwash following a dietary nitrate load.
Mary N. Woessner,Mary N. Woessner,James M. Smoliga,Brendan Tarzia,Thomas Stabler,Mitch Van Bruggen,Jason D. Allen,Jason D. Allen +7 more
TL;DR: Results suggest a potentially differentiating effect of different commercially available mouthwash solutions on plasma and salivary nitrite concentrations and resting blood pressure responses and raises potential public health related questions on the appropriate widespread usage of different mouthwash formulations.
Journal ArticleDOI
Plasma nitrate and nitrite are increased by a high-nitrate supplement but not by high-nitrate foods in older adults.
Gary D. Miller,Anthony P. Marsh,Robin W. Dove,Daniel P. Beavers,Tennille D. Presley,Tennille D. Presley,Christine C. Helms,Erika Bechtold,S. Bruce King,Daniel B. Kim-Shapiro +9 more
TL;DR: In healthy older adults, a high-nitrate supplement consumed at breakfast elevated plasma nitrate and nitrite levels throughout the day, and this observation may have practical utility for the timing of intake of a nitrate supplement with physical activity for older adults with vascular dysfunction.
Journal ArticleDOI
Novel angiogenesis therapeutics by redox injectable hydrogel - Regulation of local nitric oxide generation for effective cardiovascular therapy.
Long Binh Vong,Long Binh Vong,Thang Quoc Bui,Tsutomu Tomita,Hiroaki Sakamoto,Yuji Hiramatsu,Yukio Nagasaki +6 more
TL;DR: It is found that NO-RIG treatment significantly enhanced the angiogenesis and new blood vessels formation in mice through the regulation of the NO sustained release and redox equilibrium.
Journal ArticleDOI
Mechanisms of Human Erythrocytic Bioactivation of Nitrite
Chen Liu,Nadeem Wajih,Xiaohua Liu,Swati Basu,John Janes,Madison Marvel,Christian Keggi,Christine C. Helms,Amber N. Lee,Andrea Belanger,Debra I. Diz,Paul J. Laurienti,David L. Caudell,Jun Wang,Mark T. Gladwin,Daniel B. Kim-Shapiro +15 more
TL;DR: Overall the data suggest that deoxyhemoglobin is the primary erythrocytic nitrite reductase operating under physiological conditions and accounts for nitrite-mediated NO signaling in blood.
References
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Journal ArticleDOI
The L-Arginine-Nitric Oxide Pathway
Salvador Moncada,Annie Higgs +1 more
TL;DR: The discovery that mammalian cells generate nitric oxide, a gas previously considered to be merely an atmospheric pollutant, is providing important information about many biologic processes.
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A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Lawrence J. Appel,Thomas Burton Moore,Thomas Burton Moore,Eva Obarzanek,William M. Vollmer,Laura P. Svetkey,Frank M. Sacks,George A. Bray,Thomas M. Vogt,Jeffrey A. Cutler,Marlene M. Windhauser,Pao-Hwa Lin,Njeri Karanja,Denise G. Simons-Morton,Marjorie L. McCullough,Janis F. Swain,Priscilla Steele,Marguerite Evans,Edgar R. Miller,David W. Harsha +19 more
TL;DR: In this paper, the effects of dietary patterns on blood pressure were assessed in a clinical trial, Dietary Approaches to Stop Hypertension, where the subjects were fed a control diet that was low in fruits, vegetables, and dairy products, with a fat content typical of the average diet in the United States.
Journal ArticleDOI
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation.
Kenyatta Cosby,Kristine S. Partovi,Jack H. Crawford,Rakesh P. Patel,Christopher D. Reiter,Sabrina Martyr,Benjamin K. Yang,Myron A. Waclawiw,Gloria Zalos,Xiuli Xu,Kris T. Huang,Howard Shields,Daniel B. Kim-Shapiro,Alan N. Schechter,Richard O. Cannon,Mark T. Gladwin +15 more
TL;DR: It is suggested that nitrite represents a major bioavailable pool of NO, and a new physiological function for hemoglobin as a nitrite reductase is described, potentially contributing to hypoxic vasodilation.
Journal Article
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.
Louis J. Ignarro,Howard Lippton,J C Edwards,William H. Baricos,Albert L. Hyman,P. J. Kadowitz,Carl A. Gruetter +6 more
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Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite.
TL;DR: An L-arginine-dependent biochemical pathway synthesizing L-citrulline and nitrite, coupled to an effector mechanism, is shown to cause this pattern of metabolic inhibition in cytotoxic activated macrophages.