Journal ArticleDOI
The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics
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TLDR
This Review discusses the emerging important biological functions of the nitrate–nitrite–NO pathway, and highlights studies that implicate the therapeutic potential of nitrate and nitrite in conditions such as myocardial infarction, stroke, systemic and pulmonary hypertension, and gastric ulceration.Abstract:
The inorganic anions nitrate (NO3-) and nitrite (NO2-) were previously thought to be inert end products of endogenous nitric oxide (NO) metabolism However, recent studies show that these supposedly inert anions can be recycled in vivo to form NO, representing an important alternative source of NO to the classical L-arginine-NO-synthase pathway, in particular in hypoxic states This Review discusses the emerging important biological functions of the nitrate-nitrite-NO pathway, and highlights studies that implicate the therapeutic potential of nitrate and nitrite in conditions such as myocardial infarction, stroke, systemic and pulmonary hypertension, and gastric ulcerationread more
Citations
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Enhancement of angiogenesis and epithelialization processes in mice with burn wounds through ROS/RNS signals generated by non-thermal N2/Ar micro-plasma
TL;DR: The generated ROS/RNS signals stimulated the burn wound healing process, which were correlated with the angiogenesis and epithelialization processes, and a possible in vivo mechanism for the enhancement of the processes in the plasma-exposed mice is proposed.
Journal ArticleDOI
Two different approaches to restore renal nitric oxide and prevent hypertension in young spontaneously hypertensive rats: l-citrulline and nitrate
Shao-Ju Chien,Kuan-Miao Lin,Hsuan-Chang Kuo,Chien-Fu Huang,Ying-Jui Lin,Li-Tung Huang,You-Lin Tain +6 more
TL;DR: The findings suggest that both NOS-dependent and -independent approaches in the prehypertensive stage toward augmentation of NO can prevent the development of hypertension in young spontaneously hypertensive rats (SHRs).
Journal ArticleDOI
A Novel Protein Protects Bacterial Iron-Dependent Metabolism from Nitric Oxide
TL;DR: The data reveal the breadth of the toxic effects of NO on metabolism and identify the function of an important enzyme in alleviating this stress and demonstrate that NnrS is particularly important for resistance to nitrosative stress under anaerobic conditions.
Journal ArticleDOI
Effects of supervised exercise and dietary nitrate in older adults with controlled hypertension and/or heart failure with preserved ejection fraction.
Hossam A. Shaltout,Joel Eggebeen,Anthony P. Marsh,Peter H. Brubaker,Paul J. Laurienti,Jonathan H. Burdette,Swati Basu,Ashley R. Morgan,Patricia C. Dos Santos,James L. Norris,Timothy M. Morgan,Gary D. Miller,W. Jack Rejeski,Amret T. Hawfield,Debra I. Diz,J. Thomas Becton,Daniel B. Kim-Shapiro,Dalane W. Kitzman +17 more
TL;DR: The main result was that there was no added benefit observed for any outcomes when comparing BRJ to placebo in either HTN or HFpEF patients undergoing exercise training, and future work is needed to determine if larger nitrate doses would provide an added benefit to supervised aerobic exercise in HTN and HFp EF patients.
Journal ArticleDOI
ZIF-Based Nanoparticles Combine X-Ray-Induced Nitrosative Stress with Autophagy Management for Hypoxic Prostate Cancer Therapy
Yanli Li,Yanli Li,Teng Gong,Hongbao Gao,Yang Chen,Huiyan Li,Peiran Zhao,Peiran Zhao,Yaqin Jiang,Yaqin Jiang,Kun Wang,Yelin Wu,Xiangpeng Zheng,Wenbo Bu,Wenbo Bu +14 more
TL;DR: In this paper, an electrophilic zeolitic imidazole framework (ZIF-82-PVP) was used for hypoxic prostate cancer therapy by inhibiting autophagy and inducing nitrosative stress based on a pH-responsive PVP nanoparticles.
References
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Journal ArticleDOI
The L-Arginine-Nitric Oxide Pathway
Salvador Moncada,Annie Higgs +1 more
TL;DR: The discovery that mammalian cells generate nitric oxide, a gas previously considered to be merely an atmospheric pollutant, is providing important information about many biologic processes.
Journal ArticleDOI
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Lawrence J. Appel,Thomas Burton Moore,Thomas Burton Moore,Eva Obarzanek,William M. Vollmer,Laura P. Svetkey,Frank M. Sacks,George A. Bray,Thomas M. Vogt,Jeffrey A. Cutler,Marlene M. Windhauser,Pao-Hwa Lin,Njeri Karanja,Denise G. Simons-Morton,Marjorie L. McCullough,Janis F. Swain,Priscilla Steele,Marguerite Evans,Edgar R. Miller,David W. Harsha +19 more
TL;DR: In this paper, the effects of dietary patterns on blood pressure were assessed in a clinical trial, Dietary Approaches to Stop Hypertension, where the subjects were fed a control diet that was low in fruits, vegetables, and dairy products, with a fat content typical of the average diet in the United States.
Journal ArticleDOI
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation.
Kenyatta Cosby,Kristine S. Partovi,Jack H. Crawford,Rakesh P. Patel,Christopher D. Reiter,Sabrina Martyr,Benjamin K. Yang,Myron A. Waclawiw,Gloria Zalos,Xiuli Xu,Kris T. Huang,Howard Shields,Daniel B. Kim-Shapiro,Alan N. Schechter,Richard O. Cannon,Mark T. Gladwin +15 more
TL;DR: It is suggested that nitrite represents a major bioavailable pool of NO, and a new physiological function for hemoglobin as a nitrite reductase is described, potentially contributing to hypoxic vasodilation.
Journal Article
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.
Louis J. Ignarro,Howard Lippton,J C Edwards,William H. Baricos,Albert L. Hyman,P. J. Kadowitz,Carl A. Gruetter +6 more
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Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite.
TL;DR: An L-arginine-dependent biochemical pathway synthesizing L-citrulline and nitrite, coupled to an effector mechanism, is shown to cause this pattern of metabolic inhibition in cytotoxic activated macrophages.