The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.
Yan Rong Guo,Qing Dong Cao,Zhong Si Hong,Yuan Yang Tan,Shoudeng Chen,Hong Jun Jin,Kai Sen Tan,De Yun Wang,Yan Yan +8 more
TLDR
The latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19 are summarized, and the current treatment and scientific advancements to combat the epidemic novel coronavirus are discussed.Abstract:
An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.read more
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A gradient boosting machine learning approach in modeling the impact of temperature and humidity on the transmission rate of COVID-19 in India
TL;DR: The gradient boosting model (GBM) has been implemented to explore the effect of the minimum temperature, maximum temperature, minimum humidity, and maximum humidity on the infection count of COVID-19 and results in the best accuracy.
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Closing the Psychological Treatment Gap During the COVID-19 Pandemic With a Supportive Text Messaging Program: Protocol for Implementation and Evaluation.
Vincent I. O. Agyapong,Vincent I. O. Agyapong,Marianne Hrabok,Marianne Hrabok,Wesley Vuong,April Gusnowski,Reham Shalaby,Kelly Mrklas,Kelly Mrklas,Daniel Li,Daniel Li,Liana Urichuk,Liana Urichuk,Mark Snaterse,Shireen Surood,Bo Cao,Xin-Min Li,Russell Greiner,Andrew James Greenshaw,Andrew James Greenshaw +19 more
TL;DR: This COVID-19 project will provide key information regarding prevalence rates of stress, anxiety, and depressive symptoms during the pandemic; demographic correlates of distress; and outcome data related to this scalable population-level intervention.
Journal ArticleDOI
Cannabis for COVID-19: Can cannabinoids quell the cytokine storm?
TL;DR: As the infection with SARS-CoV-2 causes inflammation due to immune response and a ‘cytokine storm’, resulting in a range of mild to no symptoms all the way to severe and critical COVID-19 induced comorbidity and mortality, this Editorial discusses the potential of the pharmacological immune-modulatory effects of cannabinoids that are constituents of the cannabis plant.
Journal ArticleDOI
Bats, pangolins, minks and other animals - villains or victims of SARS-CoV-2?
Beatriz do Vale,Ana Patrícia Lopes,Maria da Conceição Fontes,Mário Silvestre,Luís Cardoso,Ana Cláudia Coelho +5 more
TL;DR: In this article, the authors provide the information available so far on the likely animal origin of SARS-CoV-2 and its possible hosts/reservoirs as well as all natural animal infections and experimental evidence using animal models.
Journal ArticleDOI
Targeting the 3CLpro and RdRp of SARS-CoV-2 with phytochemicals from medicinal plants of the Andean Region: molecular docking and molecular dynamics simulations.
TL;DR: Computational analyses revealed that the interaction with hesperidin remained stable in both enzymes, unveiling its remarkable potential as a possible multitarget antiviral agent to treat COVID-19.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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