The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.
Yan Rong Guo,Qing Dong Cao,Zhong Si Hong,Yuan Yang Tan,Shoudeng Chen,Hong Jun Jin,Kai Sen Tan,De Yun Wang,Yan Yan +8 more
TLDR
The latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19 are summarized, and the current treatment and scientific advancements to combat the epidemic novel coronavirus are discussed.Abstract:
An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.read more
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YouTube as a source of medical information on the novel coronavirus 2019 disease (COVID-19) pandemic.
Ryan S D'Souza,Shawn D'Souza,Natalie Strand,Alexandra Anderson,Matthew N.P. Vogt,Oludare O Olatoye +5 more
TL;DR: Although YouTube generally is a useful source of medical information on the COVID-19 pandemic, increased efforts to disseminate accurate information from reputable sources is desired to help mitigate disease spread and decrease unnecessary panic in the general population.
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Taking the pulse of COVID-19: A spatiotemporal perspective.
Chaowei Yang,Dexuan Sha,Qian Liu,Yun Li,Hai Lan,Weihe Wendy Guan,Tao Hu,Zhenlong Li,Zhiran Zhang,John Hoot Thompson,Zifu Wang,David Wong,Shiyang Ruan,Manzhu Yu,Douglas Richardson,Luyao Zhang,Ruizhi Hou,You Zhou,Cheng Zhong,Yifei Tian,Fayez Beaini,Kyla Carte,Colin Flynn,Liu Wei,Dieter Pfoser,Shuming Bao,Mei Li,Haoyuan Zhang,Chunbo Liu,Jie Jiang,Shihong Du,Liang Zhao,Mingyue Lu,Lin Li,Huan Zhou +34 more
TL;DR: This perspective paper presents the collective view on the global health emergency and the effort in collecting, analyzing, and sharing relevant data on global policy and government responses, human mobility, environmental impact, socioeconomical impact, and reflecting on the dynamic responses from human societies.
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Three cases of treatment with nafamostat in elderly patients with COVID-19 pneumonia who need oxygen therapy.
Sukbin Jang,Ji-Young Rhee +1 more
TL;DR: Preliminary findings show the possibility that Nafamostat can be considered to be used in elderly patients with COVID-19 pneumonia who need oxygen therapy, and the effectiveness of nafamstat should be evaluated in further studies.
Journal ArticleDOI
Possibility of magnesium supplementation for supportive treatment in patients with COVID-19.
TL;DR: The effectiveness of magnesium supplementation on the disorders or diseases, and a reference to the possibility of magnesium supplements for supportive treatment in patients with COVID-19 are provided.
Journal ArticleDOI
COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric Implications.
Vicky Yamamoto,Joe Bolanos,John Fiallos,Susanne E. Strand,Kevin Morris,Sanam Shahrokhinia,Tim R. Cushing,Lawrence Hopp,Ambooj Tiwari,Robert J. Hariri,Rick Sokolov,Christopher Wheeler,Ajeet Kaushik,Ashraf Elsayegh,Dawn Eliashiv,Rebecca Hedrick,Behrouz Jafari,J. Patrick Johnson,Mehran Khorsandi,Nestor R Gonzalez,Guita Balakhani,Shouri Lahiri,Kazem Ghavidel,Marco Amaya,Harry Kloor,Namath Hussain,Edmund Huang,Jason Cormier,J. Wesson Ashford,Jeffrey C. Wang,Shadi Yaghobian,Payman Khorrami,Bahman Shamloo,Charles N Moon,Payam Shadi,Babak Kateb +35 more
TL;DR: A comprehensive review of SARS-CoV-2-induced disease, its mechanism of infection, diagnostics, therapeutics, and treatment strategies, while also focusing on less attended aspects by previous studies, including nutritional support, psychological, and rehabilitation of the pandemic and its management
References
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
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TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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