The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.
Yan Rong Guo,Qing Dong Cao,Zhong Si Hong,Yuan Yang Tan,Shoudeng Chen,Hong Jun Jin,Kai Sen Tan,De Yun Wang,Yan Yan +8 more
TLDR
The latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19 are summarized, and the current treatment and scientific advancements to combat the epidemic novel coronavirus are discussed.Abstract:
An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.read more
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An Update on COVID-19 Pandemic: The Epidemiology, Pathogenesis, Prevention and Treatment Strategies.
Hin Fung Tsang,Lawrence W. C. Chan,William C. Cho,Allen Chi-Shing Yu,Aldrin Kay-Yuen Yim,Amanda Kit Ching Chan,Lawrence Po Wah Ng,Yin Kwan Evelyn Wong,Xiao Meng Pei,Marco Jing Woei Li,Sze Chuen Cesar Wong +10 more
TL;DR: The current knowledge on COVID-19 and the pandemic worldwide is summarized and the epidemiology, pathogenesis, prevention and different treatment options will be discussed so that the authors shall prepare ourselves better to fight with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Journal ArticleDOI
SARS-CoV-2 jumping the species barrier: Zoonotic lessons from SARS, MERS and recent advances to combat this pandemic virus.
Kuldeep Dhama,Shailesh Kumar Patel,Khan Sharun,Mamta Pathak,Ruchi Tiwari,Mohd Iqbal Yatoo,Yashpal Singh Malik,Ranjit Sah,Ali A. Rabaan,Parmod Kumar Panwar,Karam Pal Singh,Izabela Michalak,Wanpen Chaicumpa,Dayron F. Martinez-Pulgarin,D. Katterine Bonilla-Aldana,Alfonso J. Rodriguez-Morales +15 more
TL;DR: A comprehensive overview of COVID-19 and SARS-CoV-2 is presented, with emphasis on the role of animals and their jumping the cross-species barriers, experiences learned from Sars- and MERS-CoVs, zoonotic links, and spillover events, transmission to humans and rapid spread.
Journal ArticleDOI
Physical Medicine and Rehabilitation and Pulmonary Rehabilitation for COVID-19.
TL;DR: This analysis extrapolates information from previous studies and experiences to bring physical medicine and rehabilitation perspective and intervention to the multidisciplinary treatment of COVID-19.
Journal ArticleDOI
Socioeconomic inequalities in the spread of coronavirus-19 in the United States: A examination of the emergence of social inequalities.
TL;DR: Results indicate that higher SES was associated with earlier incidence of index cases, but that as social distancing took place inequalities in SES inverted so that growth in incidence was slower in high SES counties, where case-fatality rates were lower.
Journal ArticleDOI
Hand hygiene during COVID-19: Recommendations from the American Contact Dermatitis Society.
Chandler W Rundle,Colby L. Presley,Michelle Militello,Cara Barber,Douglas L. Powell,Sharon E. Jacob,Sharon E. Jacob,Sharon E. Jacob,Amber Reck Atwater,Kalman L. Watsky,JiaDe Yu,Cory A. Dunnick,Cory A. Dunnick +12 more
TL;DR: An overview of the most frequently used hand hygiene products and their associations with contact dermatitis as well as recommendations from the ACDS on how to treat and prevent further dermatitis are provided.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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