The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain.
Winship Herr,Michele A. Cleary +1 more
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This article is published in Genes & Development.The article was published on 1995-07-15 and is currently open access. It has received 398 citations till now. The article focuses on the topics: POU domain & HMG-box.read more
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Oct-4: gatekeeper in the beginnings of mammalian development.
Maurizio Pesce,Hans R. Schöler +1 more
TL;DR: Novel advances along with latest findings on Oct‐4‐associated factors, target genes, and dimerization ability, provide new insights into the understanding of the early steps regulating mammalian embryogenesis.
Scholer hr. oct-4: gatekeeper in the beginnings of mammalian development
Maurizio Pesce,Hans R. Schöler +1 more
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Recruitment of RNA polymerase III to its target promoters
Laura Schramm,Nouria Hernandez +1 more
TL;DR: A key step in retrieving the information stored in the complex genomes of eukaryotes involves the identification of transcription units and, more specifically, the recognition of promoter sequences by RNA polymerase.
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POU domain family values: flexibility, partnerships, and developmental codes.
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Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation
TL;DR: Evidence is provided that Oct-4 undergoes downregulation during oogenesis and spermatogenesis, coincident with entry into meiosis, and analysis of maturation stages of oocytes showed thatOct-4 is upregulated de novo in the final stages of meiotic prophase I in female germ cells, suggesting one of the molecular triggers involved in the commitment to meiosis.
References
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Transcription factors: structural families and principles of DNA recognition
Carl O. Pabo,Robert T. Sauer +1 more
TL;DR: Familiarity, ease of access, trust, and awareness of benefits and risks to minimize uncertainty, will all be important for the sustained support of existing and new generations of DNA-B isolaters.
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A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.
Mitchell H. Rosner,M A Viganò,Keiko Ozato,P. M. Timmons,F. Poirier,F. Poirier,Peter W. J. Rigby,Louis M. Staudt +7 more
TL;DR: The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain, which is expressed in the totipotent and pluripotent stem cells of the pre-gastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development.
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A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype.
Holly A. Ingraham,Ruoping Chen,Harry J. Mangalam,Harry P. Elsholtz,Sarah E. Flynn,Chijen R. Lin,Donna M. Simmons,Donna M. Simmons,Larry W. Swanson,Michael G. Rosenfeld +9 more
TL;DR: The structure of Pit-1 and its recognition elements suggests that metazoan tissue phenotype is controlled by a family of transcription factors that bind to related cis-active elements and contain several highly conserved domains.
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Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: a framework for understanding homeodomain-DNA interactions.
TL;DR: The crystal structure of a complex containing the engrailed homeodomain and a duplex DNA site has been determined at 2.8 A resolution and refined to a crystallographic R factor of 24.4%.
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A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes.
TL;DR: It is reported here the identification of a human B-cell nuclear factor (IgNF-A) that binds to DNA sequences in the upstream regions of both the mouse heavy and κ light-chain gene promoters and also to the mouseHeavychain gene enhancer.