The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4
TLDR
The proto-oncogene c-maf, a basic region/leucine zipper transcription factor, controls tissue-specific expression of IL-4 in Th1 cells, B cells, and nonlymphoid cells and acts in synergy with the nuclear factor of activated T cells (NF-ATp) to initiate endogeneous IL- 4 production by B cells.About:
This article is published in Cell.The article was published on 1996-06-28 and is currently open access. It has received 689 citations till now. The article focuses on the topics: Ectopic expression & Interleukin 21.read more
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Heon Park,Zhaoxia Li,Xuexian O. Yang,Seon Hee Chang,Roza Nurieva,Yi Hong Wang,Ying Wang,Leroy Hood,Zhou Zhu,Qiang Tian,Chen Dong +10 more
TL;DR: In vivo, antibody to IL- 17 inhibited chemokine expression in the brain during experimental autoimmune encephalomyelitis, whereas overexpression of IL-17 in lung epithelium caused Chemokine production and leukocyte infiltration, indicating a unique T helper lineage that regulates tissue inflammation.
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A novel transcription factor, T-bet, directs Th1 lineage commitment.
Susanne J. Szabo,Sean T Kim,Gina L. Costa,Xiankui Zhang,C. Garrison Fathman,Laurie H. Glimcher +5 more
TL;DR: T-bet initiates Th1 lineage development from naive Thp cells both by activating Th1 genetic programs and by repressing the opposing Th2 programs, as evidenced by the simultaneous induction of IFNgamma and repression of IL-4 and IL-5.
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TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
TL;DR: Recent data on the diversity of the NFAT family of transcription factors, the regulation of NFAT proteins within cells, and the cooperation ofNFAT proteins with other transcription factors to regulate the expression of inducible genes are discussed.
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Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.
Mary E. Brunkow,Jeffery Ew,Hjerrild Ka,Bryan W. Paeper,L B Clark,Yasayko Sa,John E. Wilkinson,David J. Galas,Steven F. Ziegler,Fred Ramsdell +9 more
TL;DR: Genetic complementation demonstrates that the protein product of Foxp3, scurfin, is essential for normal immune homeostasis.
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The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
TL;DR: In transgenic mice, elevated GATA-3 in CD4 T cells caused Th2 cytokine gene expression in developing Th1 cells, indicating that Gata-3 is necessary and sufficient for Th2inflammatory gene expression.
References
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Journal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
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Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells
Robert A. Seder,W E Paul +1 more
TL;DR: IL-4 strikingly diminishes priming forIFN gamma production, although this inhibitory effect is blunted in the presence of IL-12, and IFN gamma similarly diminishesPriming for IL-4 production; this effect is principally observed when low concentrations of IL -4 are used in the priming culture.
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Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A.
TL;DR: NF-AT is formed when a signal from the antigen receptor induces a pre-existing cytoplasmic subunit to translocate to the nucleus and combine with a newly synthesized nuclear subunit of NF-AT, forming a inhibitory complex between the drug and isomerase.
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The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun.
Jugnu Jain,Patricia G. McCaffrey,Z. Miner,Z. Miner,Tom K. Kerppola,John Lambert,Gregory L. Verdine,Tom Curran,Anjana Rao +8 more
TL;DR: The interaction between the lymphoid-specific factor NFATp and the ubiquitous transcription factors Fos and Jun provides a novel mechanism for combinatorial regulation of interleukin-2 gene transcription, which integrates the calcium-dependent and the protein-kinase C-dependent pathways of T-cell activation.